奈良先端科学技術大学院大学 バイオサイエンス研究科 分子免疫制御(河合研究室)

Publications(2013年以降)

【2019】
Kawasaki T, Kawai T.
Discrimination between self and non-self-nucleic acids by the innate immune system.
Int Rev Cell Mol Biol. 2019 344:1-30.
PMID: 30798985
 
 
【2018】
Sok SPM*, Ori D*, Nagoor NH, Kawai T.
Sensing self and non-self DNA by innate immune receptors and their signaling pathways.
Crit Rev Immunol. 2018; 38(4):279-301.
PMID: 30806244
 
Sueyoshi T, Kawasaki T, Kitai Y, Ori D, Akira S, Kawai T.
Hu Antigen R regulates antiviral innate immune responses through the stabilization of mRNA for Polo-like kinase 2.
J Immunol. 2018 Jun 1;200(11):3814-3824.
PMID: 29678949
 
Murase M, Kawasaki T*Hakozaki R, Sueyoshi T, Putri DDDP, Kitai Y, Sato S, Ikawa M, Kawai T*.
Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through TLR4 trafficking
J Immunol. 2018 Apr 15;200(8):2798-2808.
PMID: 29540576
 
 
【2017】
Kawasaki T*, Ito K, Miyata H, Akira S, Kawai T*.
Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
EMBO J. 2017 Jun 14;36(12):1707-1718.
PMID:28533230
 
Ori D, Murase M, Kawai T.
Cytosolic nucleic acid sensors and innate immune regulation.
Int Rev Immunol. 2017 Mar 4;36(2):74-88.
PMID:28333574
 
Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T.
Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.
Proc Natl Acad Sci USA. 2017 Feb 15;198(4):1649-1659.
PMID: 28213497
 
Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T.
DNA-containing exosomes derived from cancer cells treated with Topotecan activate a STING-dependent pathway and reinforce antitumor immunity. 
J Immunol. 2017 Feb 15;098(4):1649-1659.
PMID: 28069806
 
奥出遥奈中川実優川崎拓実河合太郎
炎症・自然免疫研究の最近の進歩
血液内科(科学評論社)第75号第5号(11月号)、p551-557.
 
鍛代悠一河合太郎
がん細胞のDAMPsと自然免疫
炎症と免疫(先端医学社)2017. vol 25. no 5, 383-388(9月号)
 
織大祐河合太郎
自然免疫
免疫ペディア(羊土社)第2章
 
 
【2016】
Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saito T, Suzuki Y, Martino MM, Kumagai Y, Akira S
Bone-protective functions of Netrin 1 protein.
J Biol Chem. 2016 Nov 11;291(46):23854-23868.
PMID: 27681594
 
村瀬本弥末吉拓也河合太郎
ダメージ関連分子(DAMPs)と慢性炎症
最新醫學 71巻11月増刊号(通巻917号)
 
 
【2015】
Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.
IPS-1 defferentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.
Cell Death Dis. 2015 Mar 7;6:e1758.
PMID: 25950488
 
Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K.
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Nat Commun. 2015 Mar 9;6:6514. 
PMID: 25751136
 
Pandey S, Kawai T, Akira S.
Microbial sensing by toll-like receptors and intracellular nucleic acid sensors.
Cold Spring Harb Perspect Med. 2015 Jan;5(1):a016246.
PMID: 25713826
 
Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T.
Negative regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like Protein 5B.
J Biol Chem. 2015 Jan 9; 290(2): 1269-80.
PMID: 25451939
 
 
【2014】
Kawasaki T, Kawai T.
Toll-like receptor signaling pathways.
Front Immunol. 2014 Sep 25; 5:461.
PMID: 25309543
 
Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T.
Nucleic acid sensing by T cells initiates Th2 cell differentiation.
Nat Commun. 2014 Apr 10;5:3566.
PMID: 24717539
 
Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T.
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51.
PMID: 24706898
 
Schmolke M, Patel JR, de Castro E, Sanchez-Aparicio MT, Uccellini MB, Miller JC, Manicassamy B, Satoh T, Kawai T, Akira S, Merad M, Garcia-Sastre A.
RIG-I detects mRNA of intracellular Salmonella enterica Serovar Typhimurium during bacterial infection.
MBio. 2014 Apr 1;5(2). pii: e01006-14.
PMID: 24692634
 
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S.
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Nat Commun. 2014 Mar 18;5:3492.
PMID: 24637670
 
Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y.
Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
J Virol. 2014 Feb;88(4):2157-67.
PMID: 24335288
 
末吉拓也村瀬元弥河合太郎
TRIM分子による核酸に対するパターン認識レセプターの制御反応
臨床免疫•アレルギー科(科学評論社)62(1), 120
 
 
【2013】
Kawasaki T, Takemura N, Standley DM, Akira S, Kawai T.
The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling.
Cell Host Microbe. 2013 Aug 14;14(2):148-58.
PMID: 23954154
 
Dorner M, Horwitz JA, Donovan BM, Labitt RN, Budell WC, Friling T, Vogt A, Catanese MT, Satoh T, Kawai T, Akira S, Law M, Rice CM, Ploss A.
Completion of the entire hepatitis C virus life cycle in genetically humanized mice.
Nature. 2013 Sep 12;501(7466):237-41.
PMID: 23903655
 
Zou J, *Kawai T, Tsuchida T, Kozaki T, Tanaka H, Shin KS, Kumar H, *Akira S.
Poly IC triggers a Cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.
Immunity. 2013 Apr 18;38(4):717-28.
PMID: 23601685
*correspondence
 
Fujikura D, Chiba S, Muramatsu D, Kazumata M, Nakayama Y, Kawai T, Akira S, Kida H, Miyazaki T.
Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza.
PLoS One. 2013;8(2):e55321.
PMID: 23408968
 
Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74.
PMID: 23388631
 
川崎拓実、審良静男、河合太郎
自然免疫ホスファチジルイノシトール5-リン酸による自然免疫応答の制御
ライフサイエンス新着論文レビュー
 
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