151) Kawasaki T, Ikegawa M, Kawai T. Antigen-presenting cells and lung CD8⁺ resident memory T cells coordinate local immune protection and shape responses to respiratory virus infection. Int Immunol. 2025 Jun 10:dxaf033. PMID: 40490946

150) Ikegawa M, Kano N, Ori D, Fukuta M, Hirano M, Hewson R, Yoshii K, Kawai T, Kawasaki T. HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA. PLoS Negl Trop Dis. 2024 Sep 30;18(9):e0012553. PMID: 39348382

149) Nanakorn Z, Kawai T, Tassanakajon A. Cytokine-like-Vago-mediated antiviral response in Penaeus monodon via IKK-NF-κB signaling pathway. iScience 2024 May 31;27(7):110161. PMID: 38974974

148) Lim JJ, Murata Y, Yuri S, Kitamuro K, Kawai T, Isotani A. Generating an organ‑deficient animal model using a multi‑targeted CRISPR‑Cas9 system. Sci Rep. 2024 May 9;14(1)10636. PMID: 38724644

147) Kano N, Miki T, Uehara Y, Ori D, Kawai T. Identification and characterization of putative enhancer regions that direct Il6 transcription in murine macrophages. Int Immunol. 2024 Apr 22;36(9):471-481 PMID: 38646837

146) Kawai T, Ikegawa M, Ori D, Akira S. Decoding Toll-like receptors: Recent insights and perspectives in innate immunity. Immunity 2024 Apr 9;57(4):649-673. PMID: 38599164

145) Konaka H, Kato Y, Hirano T, Tsujimoto K, Park J, Koba T, Aoki W, Matsuzaki Y, Taki M, Koyama S, Itotagawa E, Jo T, Hirayama T, Kawai T, Ishii KJ, Ueda M, Yamaguchi S, Akira S, Morita T, Maeda Y, Nishide M, Nishida S, Shima Y, Narazaki M, Takamatsu H, Kumanogoh A. Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome. EMBO J. 2023 Oct 16;42(20):e112573. PMID: 37661814

144) Ori D, Kawai T. Pathological functions of self-derived DNA. Int Rev Immunol. 2023 42(4):274-286. PMID: 35499950

143) Wanvimonsuk S, Jaree P, Kawai T, Somboonwiwat K. Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation. iScience 2022 Dec 10;26(1):105793. PMID: 36619979

142) Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T. Alveolar macrophages instruct CD8⁺ T cell expansion by antigen cross-presentation in lung. Cell Rep. 2022 Dec 13;41(11):111828. PMID: 36516765

141) Kano N, Ong GH, Ori D, Kawai T. Pathophysiological role of nucleic acid-sensing pattern recognition receptors in inflammatory diseases. Front Cell Infect Microbiol. 2022 Jun 6;12:910654. PMID: 35734577

140) Yamada S, Kitai Y, Tadokoro T, Takahashi R, Shoji H, Maemoto T, Ishiura M, Muromoto R, Kashiwakura JI, Ishii KJ, Maenaka K, Kawai T, Matsuda T. Identification of RPL15 60S ribosomal protein as a novel Topotecan target protein that correlates with DAMP secretion and antitumor immune activation. J Immunol. 2022. Jul 1;209(1):171-179. PMID: 35725272

139) Kawasaki T, Ikegawa M, Kawai T. Antigen presentation in the lung. Front Immunol. 2022. May 9;13:860915. PMID: 35615351

138) Ong GH, Ori D, Kawsaki T, Kawai T. Inhibition of lipopolysaccharide-induced inflammatory responses by 1'-acetoxychavicol acetate. Genes Cells. 2022. Jul; 27(7):482-492. PMID: 35467779

137) Lian BSX, Kawasaki T, Kano N, Ori D, Ikegawa M, Isotani A, Kawai T. Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site. iScience. 2022.Mar 18;25(4):104118. PMID: 35402874

136) Soponpong S, Amparyup P, Kawai T, Tassanakajon A. Penaeus monodon Interferon Regulatory Factor (PmIRF) activates IFNs and antimicrobial peptide expression via a STING-dependent DNA sensing pathway.  Front Immunol. 2022 Jan 10;12:818267. PMID: 35082798

135) Ong GH, Lian BSX, Kawasaki T, Kawai T. Exploration of pattern recognition receptor agonists as candidate adjuvants. Front Cell Infect Microbial. 2021 Oct 6;11:745016. PMID: 34692565

134) Hasan MZ, Islam S, Matsumoto K, Kawai T. Meta-analysis of single-cell RNA-seq data reveals phenotypic switching of immune cells in severe COVID-19 patients. Compt Biol Med. 2021 Aug 27;137:104792. PMID: 34478921

133) Hasan MZ, Islam S, Matsumoto K, Kawai T. SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs. Sci Rep. 2021 Aug 19;11(1):16814. PMID: 34413339

132) Sok SPM, Ori D, Wada A, Okude H, Kawasaki T, Momota M, Nagoor NH, Kawai T. 1'-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression. Int Immunol. 2021 Jun 18;33(7):373-386. PMID: 33830232

131) Okude H, Ori D, Kawai T. Signaling through nucleic acids sensors and their roles in inflammatory diseases. Front Immunol. 2021 Jan 28;11:625833. PMID: 33633744

130) Momota M, Nagayama M, Okude H, Ishii KJ, Ori D, Kawasaki T, Kawai T. The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33. Biochem Biophys Res Commun. 2020 Oct 1;530(4):699-705. PMID: 32768188

129) Monwan W, Kawasaki T, Hasan MZ, Ori D, Kawai T. Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Biochem Biophys Res Commun. 2020 Jan 22;521(4):1077-1082. PMID:31733835

128) Zainol MIB, Kawasaki T, Monwan W, Murase M, Sueyoshi T, Kawai T. Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization. Sci Rep. 2019 Dec 31;9(1):20406. PMID:31892731

127) Soponpong S, Amparyup P, Kawai T, Tassanakajon A. A cytosolic sensor, PmDDX41, binds double stranded-DNA and triggers the activation of an innate antiviral response in the shrimp Penaeus monodon via the STING-dependent signaling pathway. Front Immunol. 2019 Aug 29;10:2069. PMID: 31552028

126) Jaree P, Kawai T, Lo CF, Tassanakajon A, Somboonwiwat K. Genome organization and definition of the Penaeus monodon viral responsive protein 15 (PmVRP15) promoter. Fish Shellfish Immunol. 2019 Oct;93:997-1006. PMID: 31412281

125) Nhnhkorn Z, Amparyup P, Kawai T, Tassanakajon A. Penaeus monodon IKKs participate in regulation of cytokine-like system and antiviral responses of innate immune system. Front Immunol. 2019 Jun 25;10:1430. PMID: 31293588

124) Putri DDDP, Kawasaki T, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T. PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking. J Biol Chem. 2019 May 24;294(21):8412-8423. PMID: 30944173

123) Kawasaki T, Kawai T. Discrimination between self and non-self-nucleic acids by the innate immune system. Int Rev Cell Mol Biol. 2019 344:1-30. PMID: 30798985

122) Sok SPM, Ori D, Nagoor NH, Kawai T. Sensing self and non-self DNA by innate immune receptors and their signaling pathways. Crit Rev Immunol. 2018; 38(4):279-301. PMID: 30806244

121) Sueyoshi T, Kawasaki T, Kitai Y, Ori D, Akira S, Kawai T. Hu Antigen R regulates antiviral innate immune responses through the stabilization of mRNA for Polo-like kinase 2. J Immunol. 2018 Jun 1;200(11):3814-3824. PMID: 29678949

120) Murase M, Kawasaki T, Hakozaki R, Sueyoshi T, Putri DDDP, Kitai Y, Sato S, Ikawa M, Kawai T. Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through TLR4 trafficking. J Immunol. 2018 Apr 15;200(8):2798-2808. PMID: 29540576

119) Kawasaki T, Ito K, Miyata H, Akira S, Kawai T. Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice. EMBO J. 2017 Jun 14;36(12):1707-1718. PMID:28533230

118) Ori D, Murase M, Kawai T. Cytosolic nucleic acid sensors and innate immune regulation. Int Rev Immunol. 2017 Mar 4;36(2):74-88. PMID:28333574

117) Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc Natl Acad Sci USA. 2017 Feb 15;198(4):1649-1659. PMID: 28213497

116) Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T. DNA-containing exosomes derived from cancer cells treated with Topotecan activate a STING-dependent pathway and reinforce antitumor immunity. J Immunol. 2017 Feb 15;198(4):1649-1659. PMID: 28069806

115) Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H. IPS-1 defferentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity. Cell Death Dis. 2015 Mar 7;6:e1758. PMID: 25950488

114) Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun. 2015 Mar 9;6:6514. PMID: 25751136

113) Pandey S, Kawai T, Akira S. Microbial sensing by toll-like receptors and intracellular nucleic acid sensors. Cold Spring Harb Perspect Med. 2015 Jan;5(1):a016246. PMID: 25713826

112) Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T. Negative regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like Protein 5B. J Biol Chem. 2015 Jan 9; 290(2): 1269-80. PMID: 25451939

111) Kawasaki T, Kawai T. Toll-like receptor signaling pathways. Front Immunol. 2014 Sep 25; 5:461. PMID: 25309543

110) Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T. Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat Commun. 2014 Apr 10;5:3566. PMID: 24717539

109) Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T. Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51. PMID: 24706898

108) Schmolke M, Patel JR, de Castro E, Sanchez-Aparicio MT, Uccellini MB, Miller JC, Manicassamy B, Satoh T, Kawai T, Akira S, Merad M, Garcia-Sastre A. RIG-I detects mRNA of intracellular Salmonella enterica Serovar Typhimurium during bacterial infection. MBio. 2014 Apr 1;5(2). pii: e01006-14. PMID: 24692634

107) Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014 Mar 18;5:3492. PMID: 24637670

106) Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y. Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells. J Virol. 2014 Feb;88(4):2157-67. PMID: 24335288

105) Kawasaki T, Takemura N, Standley DM, Akira S, Kawai T. The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling. Cell Host Microbe. 2013 Aug 14;14(2):148-58. PMID: 23954154

104) Dorner M, Horwitz JA, Donovan BM, Labitt RN, Budell WC, Friling T, Vogt A, Catanese MT, Satoh T, Kawai T, Akira S, Law M, Rice CM, Ploss A. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature. 2013 Sep 12;501(7466):237-41. PMID: 23903655

103) Zou J, Kawai T, Tsuchida T, Kozaki T, Tanaka H, Shin KS, Kumar H, Akira S. Poly IC triggers a Cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis. Immunity. 2013 Apr 18;38(4):717-28. PMID: 23601685

102) Fujikura D, Chiba S, Muramatsu D, Kazumata M, Nakayama Y, Kawai T, Akira S, Kida H, Miyazaki T. Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. PLoS One. 2013;8(2):e55321. PMID: 23408968

101) Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74. PMID: 23388631