【2024】

146) Kawai T*, Ikegawa M, Ori D, Akira S*.

Decoding Toll-like receptors: Recent insights and perspectives in innate immunity.

Immunity 2024 Apr 9;57(4):649-673.

PMID: 38599164

【2023】

145) Konaka H, Kato Y, Hirano T, Tsujimoto K, Park J, Koba T, Aoki W, Matsuzaki Y, Taki M, Koyama S, Itotagawa E, Jo T, Hirayama T, Kawai T, Ishii KJ, Ueda M, Yamaguchi S, Akira S, Morita T, Maeda Y, Nishide M, Nishida S, Shima Y, Narazaki M, Takamatsu H, Kumanogoh A.

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome.

EMBO J. 2023 Oct 16;42(20):e112573.

PMID: 37661814

144) Ori D*, Kawai T*.

Pathological functions of self-derived DNA

Int Rev Immunol. 2023;42(4):274-286.

PMID: 35499950

河合太郎

自然免疫を介した病原体認識と獲得免疫の誘導

生化学 95(4):509-520

【2022】

143) Wanvimonsuk S, Jaree P, Kawai T, Somboonwiwat K.

Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation.

iScience 2022 Dec 10;26(1):105793.

PMID: 36619979

142) Kawasaki T*, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T*.

Alveolar macrophages instruct CD8⁺ T cell expansion by antigen cross-presentation in lung.

Cell Rep. 2022 Dec 13;41(11):111828. 

PMID: 36516765 

141) Kano N, Ong GH, Ori D, Kawai T*.

Pathophysiological role of nucleic acid-sensing pattern recognition receptors in inflammatory diseases.

Front Cell Infect Microbiol. 2022 Jun 6;12:910654. 

PMID: 35734577

140) Yamada S, Kitai Y, Tadokoro T, Takahashi R, Shoji H, Maemoto T, Ishiura M, Muromoto R, Kashiwakura JI, Ishii KJ, Maenaka K, Kawai T, Matsuda T.

Identification of RPL15 60S ribosomal protein as a novel Topotecan target protein that correlates with DAMP secretion and antitumor immune activation.

J Immunol. 2022. Jun 20

PMID: 35725272

139) Kawasaki T*, Ikegawa M, Kawai T*.

Antigen presentation in the lung.

Front Immunol. 2022. May 9;13:860915

PMID: 35615351

138) Ong GH, Ori D*, Kawsaki T, Kawai T*.

Inhibition of lipopolysaccharide-induced inflammatory responses by 1'-acetoxychavicol acetate

Genes Cells. 2022. Jul; 27(7):482-492

PMID: 35467779

137) Lian BSX, Kawasaki T*, Kano N, Ori D, Ikegawa M, Isotani A, Kawai T*.

Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site.

iScience. 2022.Mar 18;25(4):104118.

PMID: 35402874

136) Soponpong S, Amparyup P, Kawai T, Tassanakajon A.

Penaeus monodon Interferon Regulatory Factor (PmIRF) activates IFNs and antimicrobial peptide expression via a STING-dependent DNA sensing pathway. 

Front Immunol. 2022 Jan 10;12:818267.

PMID: 35082798

織大祐、河合太郎

異所性DNAの認識機構と生体応答

実験医学2022年3月号（特集：RNAワクチンの先の基礎研究　核酸と生体防御のメカニズムを解き明かす）

vol40, No 4, 533頁

【2021】

135) Ong GH#, Lian BSX#, Kawasaki T, Kawai T*. (#equal contribution) 

Exploration of pattern recognition receptor agonists as candidate adjuvants

Front Cell Infect Microbial. 2021 Oct 6;11:745016.

PMID: 34692565

134) Hasan MZ*, Islam S, Matsumoto K, Kawai T*. 

Meta-analysis of single-cell RNA-seq data reveals phenotypic switching of immune cells in severe COVID-19 patients.

Compt Biol Med. 2021 Aug 27;137:104792.

PMID: 34478921

133) Hasan MZ*, Islam S, Matsumoto K, Kawai T*. 

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs.

Sci Rep. 2021 Aug 19;11(1):16814.

PMID: 34413339

132) Sok SPM#, Ori D#*, Wada A, Okude H, Kawasaki T, Momota M, Nagoor NH*, Kawai T*. (#equal contribution)

1'-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression.

Int Immunol. 2021 Jun 18;33(7):373-386.

PMID: 33830232

131) Okude H, Ori D, Kawai T*. 

Signaling through nucleic acids sensors and their roles in inflammatory diseases.

Front Immunol. 2021 Jan 28;11:625833.

PMID: 33633744

河合太郎

IL-33と肺胞マクロファージ

呼吸器内科（科学評論社）第40巻第6号、2021 、P596-603

【2020】

130) Momota M#, Nagayama M#, Okude H, Ishii KJ, Ori D, Kawasaki T, Kawai T*. (#equal contribution)

The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33.

Biochem Biophys Res Commun. 2020 Oct 1;530(4):699-705.

PMID: 32768188

129) Monwan W, Kawasaki T*, Hasan MZ, Ori D, Kawai T*.

Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses.

Biochem Biophys Res Commun. 2020 Jan 22;521(4):1077-1082.

PMID:31733835

【2019】

128) Zainol MIB, Kawasaki T*, Monwan W, Murase M, Sueyoshi T, Kawai T*.

Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization.

Sci Rep. 2019 Dec 31;9(1):20406.

PMID:31892731

127) Soponpong S, Amparyup P, Kawai T, Tassanakajon A.

A cytosolic sensor, PmDDX41, binds double stranded-DNA and triggers the activation of an innate antiviral response in the shrimp Penaeus monodon via the STING-dependent signaling pathway.

Front Immunol. 2019 Aug 29;10:2069.

PMID: 31552028

126) Jaree P, Kawai T, Lo CF, Tassanakajon A, Somboonwiwat K.

Genome organization and definition of the Penaeus monodon viral responsive protein 15 (PmVRP15) promoter.

Fish Shellfish Immunol. 2019 Oct;93:997-1006.

PMID: 31412281

125) Nhnhkorn Z, Amparyup P, Kawai T, Tassanakajon A.

Penaeus monodon IKKs participate in regulation of cytokine-like system and antiviral responses of innate immune system.

Front Immunol. 2019 Jun 25;10:1430.

PMID: 31293588

124) Putri DDDP#, Kawasaki T#*, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T*. (# equal contribution)

PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.

J Biol Chem. 2019 May 24;294(21):8412-8423.

PMID: 30944173

123) Kawasaki T, Kawai T*.

Discrimination between self and non-self-nucleic acids by the innate immune system.

Int Rev Cell Mol Biol. 2019 344:1-30.

PMID: 30798985

加納規資、織大祐、河合太郎

パターン認識受容体（PRR）による自然免疫応答

The Frontiers in Life Sciencesシリーズ免疫・炎症病態×治療Update（南山堂）2019 、P 2-10

【2018】

122) Sok SPM#, Ori D#, Nagoor NH, Kawai T*. (# equal contribution)

Sensing self and non-self DNA by innate immune receptors and their signaling pathways.

Crit Rev Immunol. 2018; 38(4):279-301.

PMID: 30806244

121) Sueyoshi T, Kawasaki T, Kitai Y, Ori D, Akira S, Kawai T*.

Hu Antigen R regulates antiviral innate immune responses through the stabilization of mRNA for Polo-like kinase 2.

J Immunol. 2018 Jun 1;200(11):3814-3824.

PMID: 29678949

120) Murase M, Kawasaki T*, Hakozaki R, Sueyoshi T, Putri DDDP, Kitai Y, Sato S, Ikawa M, Kawai T*.

Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through TLR4 trafficking

J Immunol. 2018 Apr 15;200(8):2798-2808.

PMID: 29540576

【2017】

119) Kawasaki T*, Ito K, Miyata H, Akira S, Kawai T*.

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.

EMBO J. 2017 Jun 14;36(12):1707-1718.

PMID:28533230

118) Ori D, Murase M, Kawai T*.

Cytosolic nucleic acid sensors and innate immune regulation.

Int Rev Immunol. 2017 Mar 4;36(2):74-88.

PMID:28333574

117) Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T.

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

Proc Natl Acad Sci USA. 2017 Feb 15;198(4):1649-1659.

PMID: 28213497

116) Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T*.

DNA-containing exosomes derived from cancer cells treated with Topotecan activate a STING-dependent pathway and reinforce antitumor immunity.

J Immunol. 2017 Feb 15;198(4):1649-1659.

PMID: 28069806

奥出遥奈、中川実優、川崎拓実、河合太郎

炎症・自然免疫研究の最近の進歩

血液内科（科学評論社）第75号第5号（11月号）、p551-557.

鍛代悠一、河合太郎

がん細胞のDAMPsと自然免疫

炎症と免疫（先端医学社）2017. vol 25. no 5, 383-388（9月号）

織大祐、河合太郎ら

自然免疫

免疫ペディア（羊土社）第2章

【2016】

村瀬本弥、末吉拓也、河合太郎

ダメージ関連分子（DAMPs）と慢性炎症

最新醫學 71巻11月増刊号(通巻917号）

【2015】

115) Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.

IPS-1 defferentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.

Cell Death Dis. 2015 Mar 7;6:e1758.

PMID: 25950488

114) Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K.

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Nat Commun. 2015 Mar 9;6:6514.

PMID: 25751136

113) Pandey S, Kawai T, Akira S.

Microbial sensing by toll-like receptors and intracellular nucleic acid sensors.

Cold Spring Harb Perspect Med. 2015 Jan;5(1):a016246.

PMID: 25713826

112) Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T*.

Negative regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like Protein 5B.

J Biol Chem. 2015 Jan 9; 290(2): 1269-80.

PMID: 25451939

【2014】

111) Kawasaki T, Kawai T*.

Toll-like receptor signaling pathways.

Front Immunol. 2014 Sep 25; 5:461.

PMID: 25309543

110) Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T.

Nucleic acid sensing by T cells initiates Th2 cell differentiation.

Nat Commun. 2014 Apr 10;5:3566.

PMID: 24717539

109) Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T.

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51.

PMID: 24706898

108) Schmolke M, Patel JR, de Castro E, Sanchez-Aparicio MT, Uccellini MB, Miller JC, Manicassamy B, Satoh T, Kawai T, Akira S, Merad M, Garcia-Sastre A.

RIG-I detects mRNA of intracellular Salmonella enterica Serovar Typhimurium during bacterial infection.

MBio. 2014 Apr 1;5(2). pii: e01006-14.

PMID: 24692634

107) Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S.

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.

Nat Commun. 2014 Mar 18;5:3492.

PMID: 24637670

106) Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y.

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.

J Virol. 2014 Feb;88(4):2157-67.

PMID: 24335288

末吉拓也、村瀬本弥、河合太郎

TRIM分子による核酸に対するパターン認識レセプターの制御反応

臨床免疫•アレルギー科（科学評論社）62(1), 120

【2013】

105) Kawasaki T, Takemura N, Standley DM, Akira S*, Kawai T*.

The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling.

Cell Host Microbe. 2013 Aug 14;14(2):148-58.

PMID: 23954154

104) Dorner M, Horwitz JA, Donovan BM, Labitt RN, Budell WC, Friling T, Vogt A, Catanese MT, Satoh T, Kawai T, Akira S, Law M, Rice CM, Ploss A.

Completion of the entire hepatitis C virus life cycle in genetically humanized mice.

Nature. 2013 Sep 12;501(7466):237-41.

PMID: 23903655

103) Zou J#, Kawai T#*, Tsuchida T, Kozaki T, Tanaka H, Shin KS, Kumar H, Akira S*. (# equal contribution)

Poly IC triggers a Cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.

Immunity. 2013 Apr 18;38(4):717-28.

PMID: 23601685

102) Fujikura D, Chiba S, Muramatsu D, Kazumata M, Nakayama Y, Kawai T, Akira S, Kida H, Miyazaki T.

Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza.

PLoS One. 2013;8(2):e55321.

PMID: 23408968

101) Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74.

PMID: 23388631

川崎拓実、審良静男、河合太郎

ホスファチジルイノシトール5-リン酸による自然免疫応答の制御

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