100
Demoor T, Petersen BC, Morris S, Mukherjee S, Ptaschinski C, De Almeida Nagata DE, Kawai T, Ito T, Akira S, Kunkel SL, Schaller MA, Lukacs NW. IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus. J Immunol. 2012 Dec 15;189(12):5942-53.
PMID: 23136205
099
Oldenburg M, Kruger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science. 2012 Aug 31;337(6098):1111-5.
PMID: 22821982
098
Kondo T, Kawai T, Akira S. Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol. 2012 Sep;33(9):449-58.
PMID: 22721918
097
Biswas A, Meissner TB, Kawai T, Kobayashi KS. Cutting Edge: impaired MHC class I expression in mice deficient for Nlrc5/Class I transactivator. J Immunol. 2012 Jul 15;189(2):516-20.
PMID: 22711889
096
Abe T, Fukuhara T, Wen X, Ninomiya A, Moriishi K, Maehara Y, Takeuchi O, Kawai T, Akira S, Matsuura Y. CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA Is replicating, through an interaction with Toll-Like Receptor 2 and Hyaluronan. J Virol. 2012 Jun;86(11):6159-70.
PMID: 22491449
095 Kawasaki T, Kawai T, Akira S. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol Rev. 2011 Sep;243(1):61-73.
PMID: 21884167
094 Kawai T, Akira S. Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med. 2011 Sep;3(9):513-27.
PMID: 21826793
093
Matsumoto K, Kan-O K, Eguchi-Tsuda M, Fukuyama S, Asai Y, Matsumoto T, Moriwaki A, Matsunaga Y, Tsutsui H, Kawai T, Takeuchi O, Akira S, Yagita H, Azuma M, Nakanishi Y, Inoue H. Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice. Am J Respir Cell Mol Biol. 2011 Jul;45(1):31-9.
PMID: 20802088
092
Kim YG, Park JH, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C, Nunez G. Viral infection augments nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe. 2011 Jun 16;9(6):496-507.
PMID: 21669398
091 Kawai T, Akira S. Toll-like Receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 2011 May 27;34(5):637-50.
PMID: 21616434
090
Togi S, Ikeda O, Kamitani S, Nakasuji M, Sekine Y, Muromoto R, Nanbo A, Oritani K, Kawai T, Akira S, Matsuda T. Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4. J Biol Chem. 2011 May 27;286(21):19170-7.
PMID: 21454679
089
Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S. Antiviral protein Viperin promotes Toll-like Receptor 7- and Toll-like Receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity. 2011 Mar 25;34(3):352-63.
PMID: 21435586
088
Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011 Feb;30(1):16-34.
PMID: 21235323
087
Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T. NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections. J Immunol. 2011 Jan 15;186(2):994-1000.
PMID: 21148033
086
Ueta M, Kawai T, Yokoi N, Akira S, Kinoshita S. Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells. Biochem Biophys Res Commun. 2011 Jan 7;404(1):419-23.
PMID: 21130742
085
Seo SU, Kwon HJ, Song JH, Byun YH, Seong BL, Kawai T, Akira S, Kweon MN. MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection. J Virol. 2010 Dec;84(24):12713-22.
PMID: 20943980
084
Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, *Kawai T, *Akira S. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity. 2010 Nov 24;33(5):765-76.
PMID: 21074459
* Correspondence
083
Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, Miyazaki T. Influenza A virus polymerase inhibits type I interferon induction by binding to interferon {beta} promoter stimulator 1. J Biol Chem. 2010 Oct 15;285(42):32064-74.
PMID: 20699220
082 Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010 May;11(5):373-84.
PMID: 20404851
081
Kobiyama K, Takeshita F, Jounai N, Sakaue-Sawano A, Miyawaki A, Ishii KJ, Kawai T, Sasaki S, Hirano H, Ishii N, Okuda K, Suzuki K. Extra-chromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA. J Virol. 2010 Jan;84(2):822-32.
PMID: 19906922
080
Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T. IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation. Cell Death Differ. 2009 Dec;16(12):1615-21.
PMID: 19644511
079
Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T. Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal {beta}-glucan. J Immunol. 2009 Dec 15;183(12):8061-8067.
PMID: 20007575
078
Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-20846.
PMID: 19926846
077
Kumar H, Kawai T, Akira S. Toll-like receptors and innate immunity. Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5.
PMID: 19686699
076
Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S. Poly I:C-induced activation of NK cells by CD8{alpha}+ dendritic cells via the IPS-1 and TRIF-dependent pathways. J Immunol. 2009 Aug 15;183(4):2522-8..
PMID: 1963590
075
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity. 2009 Jul 17;31(1):25-34.
PMID: 19576794
074
Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, Matsuura Y. Baculovirus induces type I IFN production through TLR-dependent and -independent pathways in a cell type-specific manner. J Virol. 2009 Aug;83(15):7629-40.
PMID: 19474102
073
Kumar H, Kawai T, Akira S. Pathogen recognition in the innate immune response. Biochem J. 2009 Apr 28;420(1):1-16.
PMID: 19382893
072 Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol. 2009 Apr;21(4):317-37.
PMID: 19246554
071
Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S. Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells. J Immunol. 2009 Apr 1;182(7):3960-4.
PMID: 19299691
070
Tsuchida T, Kawai T, Akira S. Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins. Cell Res. 2009 Jan;19(1):3-4.
PMID: 19125153
069 Kawai T, Akira S Toll-like Receptor and RIG-I-like Receptor signaling. Ann N Y Acad Sci. 2008 Nov;1143:1-20.
PMID: 19076341
068
Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, van Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, Reeves WH. TLR7-dependent and Fc{gamma}R-independent production of type I interferon in experimental mouse lupus. J Exp Med. 2008 Dec 22;205(13):2995-3006.
PMID: 19047436
067
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T. TNF receptor-associated factor (TRAF) 6 and MEK kinase (MEKK) 1 play a pivotal role in the retinoic-acid-inducible gene-I (RIG-I)-like helices antiviral pathway. J Biol Chem. 2008 Dec 26;283(52):36211-20.
PMID: 18984593
066
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008 Nov 13;456(7219):264-8
PMID: 18849965
065
Ohbayashi N, Okada K, Kawakami S, Togi S, Sato N, Ikeda O, Kamitani S, Muromoto R, Sekine Y, Kawai T, Akira S, Matsuda T. Physical and functional interactions between ZIP kinase and UbcH5. Biochem Biophys Res Commun. 2008 Aug 8;372(4):708-12.
PMID: 18515077
064
Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol. 2008 Jun;9(6):684-91.
PMID: 18438411
063
Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature. 2008 Feb 7;451(7179):725-9.
PMID: 18256672
062
Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S. Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. J Immunol. 2008 Jan 15;180(2):683-7.
PMID: 18178804
061
Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces cytotoxic T cell response via MyD88. J Virol. 2008 Jan;82(1):196-206.
PMID: 17942529
060 Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007 Nov;13(11):460-9.
PMID: 18029230
059
Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S. Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol. 2007 Oct 1;179(7):4711-20.
PMID: 17878370
058
Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med. 2007 Sep 3;204(9):2233-9.
PMID: 17724128
057
Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira S. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity. 2007 Aug;27(2):240-52.
PMID: 17723216
056
Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K, Okuda K. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci USA. 2007 Aug 28;104(35):14050-5.
PMID: 17709747
055
Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen X, Taguwa S, Moriishi K, Takeuchi O, Kawai T, Kanto T, Hayashi N, Akira S, Matsuura Y. Hepatitis C Virus Nonstructural Protein 5A modulates TLR-MyD88-dependent signaling pathway in the macrophage cell lines. J Virol. 2007 Sep;81(17):8953-66.
PMID: 17567694
054
Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, van Echo D, Fitzgerald KA, Young HA, Ching LM, Vogel SN. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med. 2007 Jul 9;204(7):1559-69.
PMID: 17562815
053 Kawai T, Akira S. SnapShot: Pattern-Recognition Receptors. Cell. 2007 Jun 1;129(5):1024.
PMID: 17540179
051 Kawai T, Akira S. Antiviral signaling through pattern recognition receptors. J Biochem (Tokyo). 2007 Feb;141(2):137-45.
PMID: 17190786
050
Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S. Pathological role of Toll-like receptor signaling in cerebral malaria. Int Immunol. 2007 Jan;19(1):67-79.
PMID: 17135446
049
Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S. Pivotal function of Ubc13 in thymocyte TCR signaling. J Immunol. 2006 Dec 1;177(11):7520-4.
PMID: 17114420
048
Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S. VP1686, a Vibrio type III secretion protein, induces toll-like receptor independent apoptosis in macrophage through NF-kappa B inhibition. J Biol Chem. 2006 Dec 1;281(48):36897-36904.
PMID: 16984916
047
Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol. 2006 Oct;18(10):1405-11.
PMID: 16940043
046
Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol. 2006 Sep;7(9):962-70.
PMID: 16862162
045
Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c(+) lamina propria cells. Nat Immunol. 2006 Aug;7(8):868-74.
PMID: 16829963
044
Kumar H*, Kawai T*, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med. 2006 Jul 10;203(7):1795-1803.
PMID: 16785313
*Equal contribution
043
Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita T, Akira S. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006 May 4;441(7089):101-105.
PMID: 16625202
042 Kawai T, Akira S TLR-signaling. Cell Death Differ. 2006 May;13(5):816-825.
PMID: 16410796
041
Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S Roles of Caspase-8 and Caspase-10 in antiviral innate immune responses. J Immunol. 2006 Apr 15;176(8):4520-4524.
PMID: 16585540
040
Sato N, Kamada N, Muromoto R, Kawai T, Sugiyama K, Watanabe T, Imoto S, Sekine Y, Ohbayashi N, Ishida M, Akira S, Matsuda T. Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines. Immunol Lett. 2006 Mar 15;103(2):127-134.
PMID: 16325270
039 Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol. 2006 Feb;7(2):131-137.
PMID: 16424890
038
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol. 2006 Jan;7(1):40-48.
PMID: 16286919
037
Sato N, Kawai T, Sugiyama K, Muromoto R, Imoto S, Sekine Y, Ishida M, Akira S, Matsuda T. Physical and functional interactions between STAT3 and ZIP kinase. Int Immunol. 2005 Dec;17(12):1543-1552.
PMID: 16219639
036
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005 Nov;6(11):1087-1095.
PMID: 16186825
035 Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1; an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction Nat Immunol. 2005, Oct;6(10):981-988.
PMID: 16127453
034 Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 2005, 17(4):338-344.
PMID: 15950447
033
Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S. Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) plays an essential role for TLR7- and TLR9-mediated interferon-a induction J. Exp. Med. 2005, 201(6):915-923.
PMID: 15767370
031
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 2005 Jan 3; 201 (1): 19-25
PMID: 15630134
030 Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira S. Interferon-a induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Oct;5(10):1061-1068.
PMID: 15361868
029
Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S. The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med. 2004 Jun 21;199(12):1641-1650.
PMID: 15210742
028
Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol. 2003 Oct 15;171(8):4304-4310.
PMID: 14530355
026 Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, Hoshino K, Akira S. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol. 2001 Nov 15;167(10):5887-5894.
PMID: 11698465
025
Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol. 2001 Jul;13(7):933-940.
PMID: 11431423
024
Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol. 2001 May 1;166(9):5688-5694.
PMID: 11313410
023
Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N, Akira S. IkappaB kinase alpha is essential for mature B cell development and function. J Exp Med. 2001 Feb 19;193(4):417-426.
PMID: 11181694
022
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-745.
PMID: 11130078
021
Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, Takeda K, Akira S. Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol. 2000 Dec 15;165(12):7096-7101.
PMID: 11120839
020
Sakao Y, Kawai T, Takeuchi O, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S. Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics. 2000 Jul 1;67(1):1-7.
PMID: 10945464
018
Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol. 2000 Apr 1;164(7):3476-3479.
PMID: 10725699
017
Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Muhlradt PF, Akira S. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol. 2000 Jan 15;164(2):554-557.
PMID: 10623793
016
Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S. Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice. J Exp Med. 1999 Dec 6;190(11):1573-1582.
PMID: 10587348
015
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999 Oct;11(4):443-451.
PMID: 10549626
014 Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 1999 Jul;11(1):115-122.
PMID: 10435584
013
Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol. 1999 Aug;11(8):1357-1362.
PMID: 10421793
012 Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene. 1999 Jun 10;18(23):3471-3480.
PMID: 10376525
011
Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S. TLR6: A novel member of an expanding toll-like receptor family. Gene. 1999 Apr 29;231(1-2):59-65.
PMID: 10231569
010
Hoshino K, Tsutsui H, Kawai T, Takeda K, Nakanishi K, Takeda Y, Akira S. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol. 1999 May 1;162(9):5041-5044.
PMID: 10227969
009
Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999 Apr 1;162(7):3749-3752.
PMID: 10201887
008
Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S. Limb and skin abnormalities in mice lacking IKKalpha. Science. 1999 Apr 9;284(5412):313-316.
PMID: 10195895
007 Kawai T, Sanjo H, Akira S. Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene. 1999 Feb 18;227(2):249-255.
PMID: 10023074
006
Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem. 1998 Oct 30;273(44):29066-29071.
PMID: 9786912
005
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S.
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 1998 Jul;9(1):143-150.
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