セミナー情報

セミナー情報

Possible physical mechanisms for initiating macroscopic left-right asymmetry in animals and plants

演題 Possible physical mechanisms for initiating macroscopic left-right asymmetry in animals and plants
講演者 Prof. Christopher Henley (Department of Physics, Cornell University)
使用言語 English
日時 平成22年6月21日(月曜日) 11:00~
場所 バイオサイエンス研究科 大セミナー室
内容

How might systematic chiral or left-right (L/R) asymmetry of the body plan originate in multicellular animals and plants? Fundamental principles (of symmetry and statistical mechanics) indicate that usual biological mechanisms -- diffusion and gene regulation -- do not suffice to implement the "right-hand rule" for (e.g.) the third body axis in a developing embryo. This requires that, somehow, the microscopic handedness of biological molecules must be brought up to macroscopic scales.

There are many independent examples of left/right specification in varied organisms: human brain, C. elegans, molluscs, drosophila, Arabidopsis plant roots -- bacteria too -- and vertebrate internal organs... Only in the last-mentioned case is there an accepted answer.

It appears from experiments, in any case where there is partial understanding at the cellular/molecular level, the mechanism it always involves the cytoskeleton (actin or microtubules, which are semi macroscopic fibers from our viewpoint). Because of (1) the mentioned role of symmetry, and (2) the involvement of molecular motors (forces and motions) the left-right problem seems especially appropriate to be studied by physicists.

問合せ先 植物遺伝子機能学
橋本 隆 (hasimoto@bs.naist.jp)

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