セミナー情報
From Protein Folding to Cognition: a Serendipitous Path of Discovery
| 演題 | From Protein Folding to Cognition: a Serendipitous Path of Discovery |
| 講演者 | Dr. Peter Walter (University of California, San Francisco) |
| 使用言語 | English |
| 日時 | 2017年6月6日(火曜日) 11：00～12：30 |
| 場所 | 大セミナー室 |
| 内容 | A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays. |
| 問合せ先 | ストレス微生物科学 木俣 行雄 (kimata@bs.naist.jp) |