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セミナー情報

New human proteins that bind methylated DNA: the role of ZBTB4 and ZBTB38

演題 New human proteins that bind methylated DNA: the role of ZBTB4 and ZBTB38
講演者 Dr. Pierre-Antoine Defossez(Functional domains of eukaryotic genomes, CNRS)
使用言語 English
日時 平成25年11月8日(金曜日) 17:30~18:30
場所 L12 lecture room
内容
DNA methylation is an epigenetic process that is essential for the development of mammals. Its effect is usually linked to heterochromatinization and gene repression, and this involves methyl-binding proteins, which themselve recruit chromatin-modifying enzymes. There are three known families of methyl-binding proteins: MBD (containing MeCP2, MBD1, MBD2, and MBD4); SRA (containing UHRF1 and UHRF2), and Zinc finger (containing Kaiso, ZBTB4, and ZBTB38).
We have been investigating methyl-binding proteins of the Zinc Finger family. Kaiso has been shown to modulate Wnt signaling in Xenopus, and to increase tumorigenesis in APC+/min mutant mice. ZBTB4 is downregulated in many human cancers, and this may be due in part to the fact that it regulates the transcription of p21. Finally, ZBTB38 is the gene presenting the SNPs most tightly associated with human stature.

問合せ先 動物遺伝子機能
松田 永照 (ematsuda@bs.naist.jp)

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