セミナー情報

セミナー情報

Radical SAM enzymes in cofactor biosynthesis

演題 Radical SAM enzymes in cofactor biosynthesis
講演者 Prof. Tadhg P. Begley(Department of Chemistry, Texas A&M University)
使用言語 English
日時 平成25年5月29日(水曜日) 16:00~17:00
場所 Large seminar room
内容
In contrast to most of the other primary metabolites, radical SAM enzymes play a major role in the biosynthesis of the cofactors. This lecture will describe the reconstitution and mechanistic characterization of radical SAM mediated reactions involved in molybdopterin (MoaA), thiamin (ThiC), deazaflavin (CofG and CofH) and menaquinone (MqnC and MqnD) biosynthesis. These examples will be used to demonstrate that radical SAM enzymes are uniquely suitable for catalyzing the complex rearrangements found in cofactor biosynthesis.

問合せ先 システム微生物学
森 浩禎 (hmori@gtc.naist.jp)

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