NAIST 奈良先端科学技術大学院大学 バイオサイエンス領域



演題 器官形成を支える細胞死の動的解析 
講演者 倉永 英里奈 チームリーダー(理化学研究所 発生・再生科学総合研究センター 組織形成ダイナミクス研究チーム)
使用言語 日本語
日時 2011年10月6日(木曜日) 16:00~17:00
場所 大講義室
The cranial vasculature is essential for the survival and development of the central nervous system, and is important in stroke and other brain pathologies. Cranial vessels form in a reproducible and evolutionarily conserved manner, but the process by which these vessels assemble and acquire their stereotypic patterning remains unclear. We are using the zebrafish to better understand the mechanisms underlying cranial vascular development by (i) carrying out a precise anatomical description of the formation process, (ii) investigating the molecular mechanisms guiding vascular patterning and assembly in the brain, and (iii) using genetic screens to identify new genes important for brain vessel formation. We have found that one of the most important brain arteries, the basilar artery, is formed by a novel process of medial sprouting and migration of endothelial cells from a bilateral pair of primitive veins, the primordial hindbrain channels. Subsequent second wave of dorsal sprouting from the primordial hindbrain channels give rise to angiogenic central arteries that penetrate into the hindbrain. We have also discovered that chemokine signaling is required to direct basilar artery assembly. I will report on these and other novel molecular processes involved in the assembly of hindbrain vascular networks.
問合せ先 分子発生生物学
高橋 淑子 (