Epigenetic determinants in the healthy and diseased brain: focus on 5- hydroxymethylcytosine (5hmC) and neurodegeneration

演題

Epigenetic determinants in the healthy and diseased brain: focus on 5- hydroxymethylcytosine (5hmC) and neurodegeneration

講演者

Dr. Yanina Tsenkina (MRC Centre for Regenerative Medicine, University of Edinburgh, UK)

使用言語

English

日時

2011年3月17日(木曜日) 14：00～

場所

バイオサイエンス研究科 大セミナー室

内容

5hmC is a newly discovered epigenetic mark resulting from the oxidation of 5-methylcytosine. In mammals, 5hmC is present during embryonic development and in the adult brain. The functional importance of 5hmC in the healthy and diseased brain is unknown. We studied 5hmC in normal adult mouse brain as well as in mouse models of chronic cerebral hypoperfusion, Huntington`s disease, and human brain samples of multiple sclerosis. Our data indicate that 5hmC 1) is differentially distributed in normal brain grey/ white matter and 2) these patterns change in pathological conditions. These results suggest a role of 5hmC in neurodegeneration.

問合せ先

動物遺伝子機能学講座
松田 永照 (ematsuda@bs.naist.jp)