セミナー情報

セミナー情報

Identification of new peptidoglycan inhibitors that potentiate carbapenem activity against Methicillin-Resistant Staphylococcus aureus.

演題 Identification of new peptidoglycan inhibitors that potentiate carbapenem activity against Methicillin-Resistant Staphylococcus aureus.
講演者 Dr. Lynn Miesel (Merck & CO.)
使用言語 English
日時 平成22年5月26日(水曜日) 10:30~
場所 バイオサイエンス研究科 D105
内容

Methicillin-resistant Staphylococcus aureus (MRSA) is a major hospital and community-acquired pathogen. There are few antibiotics efficacious for treating infections caused by MRSA. This seminar will describe the identification of compounds that restore the susceptibility of MRSA to the carbapenem class of B-lactam antibiotics. Results from genetic studies indicate that the compounds act on a membrane localized protein, SAV1754, and inhibit peptidoglycan synthesis. SAV1754 is similar to the recently reported flippase, MviN/MurJ, of Excherichia coli. MviN is thought to translocate the lipid II precursor for peptidoglycan from the inside surface of the bacterial membrane to the outside surface. We propose that SAV1754 performs the same function in S. aureus. Our results indicate that SAV1754 inhibitors may be useful for developing a new therapy for MRSA.

Reference: Huber et al. Chemistry and Biology 16, p837-838. 2009.

問合せ先 生体情報学
森 浩禎 (hmori@gtc.naist.jp)

一覧へ戻る