How can protein aggregation in Parkinson’s lead to neurodegeneration?
|演題||How can protein aggregation in Parkinson’s lead to neurodegeneration?|
|講演者||Dr. Harvey T. McMahon ( MRC Laboratory of Molecular Biology, Cambridge UK )|
|場所||Rethink Biological Science Seminar Hall (L11)|
Protein aggregates are associated with many neurodegenerative diseases such as Alzheimer’s and Parkinson’s. While there is considerable evidence for protein aggregates being toxic, the molecular details and mechanism of toxicity/neurodegeneration are ambiguous. Is it the aggregate itself or the deleterious loss of an important physiological function of a protein when it aggregates? I will present data investigating these possibilities using the protein a-Synuclein found to be aggregated in Synucleinopathies.
We will also explore what might be the physiological function of alpha-synuclein and thus how this may be altered in disease. Overall, I would like to encourage discussion around what might be useful strategies for early interventions for disease therapy.
|問合せ先||Molecular Medicine and Cell Biology
Suetsugu Shiro (firstname.lastname@example.org)