Design and evolution of synthetic nucleocapsids
|演題||Design and evolution of synthetic nucleocapsids|
|講演者||Marc J. Lajoie, PhD.（Institute for Protein Design, University of Washington, Seattle）|
Nucleic acid encapsulation is a fundamental requirement of life, elegantly solving the challenges of evolution in a complex biochemical environment by coupling genotype to phenotype and protecting genetic material. In the simplest examples, viruses use capsids to surround their genomes, but they remain delicate systems that are difficult to re-engineer for therapeutic applications. Based on simple first principles, we have created synthetic nucleocapsids that encapsulate their own RNA genome, providing a “blank slate” to design and evolve desired properties for drug delivery, while avoiding the safety risks and engineering challenges associated with viruses.
Reference: Butterfield GL, Lajoie MJ, Gustafson HH, Sellers DL, Nattermann U, Ellis D, Bale JB, Ke S,