Uncharacterized Functions of PI3K
|演題||Uncharacterized Functions of PI3K|
|講演者||Prof. Takanari Inoue (Johns Hopkins University, Department of Cell Biology)|
|場所||Large Seminar room (C109)|
Classically, the main and only well-characterized function of PI3K is PI(3,4,5)P3 production through the phosphorylation of PI(4,5)P2, in response to the activation of transmembrane receptors at the cell surface. PI(3,4,5)P3 then acts as a second messenger which activates a variety of downstream effectors. Using bioinformatics and chemically-inducible dimerization approaches, we found that PI3K senses and induces membrane deformation, independently from production of PI(3,4,5)P3. Further characterization implicates importance of these functions in cell migration and receptor-mediated endocytosis.
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