The regulation of intermediate filaments: a new function for the tumor suppressor Adenomatous Polyposis Coli

演題

The regulation of intermediate filaments: a new function for the tumor suppressor Adenomatous Polyposis Coli

講演者

Dr. Yasuhisa Sakamoto (Institut Pasteur)

使用言語

English

日時

2010年10月20日(水曜日) 16：00～

場所

バイオサイエンス研究科 L１2会議室

内容

Intermediate filaments (IFs) are essential components of the cytoskeleton involved in most cellular functions including cell migration. However, the regulation of IF dynamics is still poorly understood. We found that the tumor suppressor Adenomatous Polyposis Coli (APC), a key regulator of microtubule reorganization during cell migration, directly binds IFs and bridges IFs and microtubules. APC binding to IFs positively regulates their dynamics both in vitro and in vivo. In addition, APC-mediated regulation of IFs is essential for cell migration and the loss or truncation of APC correlates with a disorganization of the IF network in cancer cells. These results point to APC as a crucial regulator of intermediate filament organization and bring new insights into APC function during cell migration.

問合せ先

生体機能制御学
佐藤 匠徳 (island1005@bs.naist.jp)