Molecular mechanisms of microtubule nucleation and dynamics - studied in reconstituted systems

演題

Molecular mechanisms of microtubule nucleation and dynamics - studied in reconstituted systems

講演者

Thomas Surrey PhD (Francis Crick Institute, London, UK)

使用言語

English

日時

2015年11月24日(火曜日) 17：00～18：00

場所

Bio Large Seminar Room

内容

The cytoskeleton is essential for the internal organization of eukaryotic cells. One hallmark of the cytoskeleton is its dynamic nature. Microtubules constantly polymerise and depolymerise. The molecular mechanisms underlying controlled microtubule nucleation and microtubule dynamic instability are still poorly understood. We address these questions using reverse engineered systems, quantitative fluorescence microscopy and image analysis. Here, we will present recent progress in understanding molecular mechanisms of microtubule cytoskeleton dynamics through reverse engineering of dynamic behavior. The focus will be on the regulation of microtubule dynamics and microtubule nucleation. The power of in vitro reconstitutions in combination with fluorescence microscopy will be illustrated in the context of regulatory proteins binding preferentially to dynamic microtubule ends. 参考文献： 1. Roostalu et al., Nat Cell Biol. 2015, doi: 10.1038/ncb3241 2. Maurer et al., Curr Biol. 2014, 24, 372-84. doi: 10.1016/j.cub.2013.12.042 3. Maurer et al., Cell. 2012, 149, 371-82. doi: 10.1016/j.cell.2012.02.049

問合せ先

神経システム生物学
稲垣　直之 (ninagaki@bs.naist.jp)