セミナー情報

セミナー情報

Decorating chromatin to protect genome integrity in S-phase

演題 Decorating chromatin to protect genome integrity in S-phase
講演者 Prof. Paul Russell
(Dept. of Cell and Molecular Biology, The Scripps Research Institute, USA)
使用言語 English
日時 平成27年6月15日(月曜日) 16:00~17:00
場所 Large Seminar Room
内容

ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3 related) are evolutionary conserved protein kinases that orchestrate cellular responses to DNA damage. One of their key substrates is the carboxyl tail of histone H2AX. Phosphorylated histone H2AX (aka γH2AX) tethers important DNA damage response (DDR) proteins to DNA double-strand breaks but its function during DNA replication is unclear. I will describe how a focused genetic screen with fission yeast has uncovered a critical requirement for formation of γH2AX during S-phase.
問合せ先 細胞シグナル研究室
塩崎 一裕 (kaz@bs.naist.jp)

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