DECIPHERING THE LANGUAGE OF CHROMATIN: Integrative analyses of genome-wide chromatin marks and genome outputs

演題

DECIPHERING THE LANGUAGE OF CHROMATIN: Integrative analyses of genome-wide chromatin marks and genome outputs

講演者

Prof. Eric Lam（Rutgers the State University of New Jersey）

使用言語

English

日時

2013年4月1日(月曜日) 15：00～16：00

場所

L12 lecture room

内容

Superimposed on the genetic code as defined by the genome sequence of an eukaryote is a complex layer of chromatin modifications. These reversible covalent modifications of both nucleotide bases such as cytosines and specific residues of various histone tails apparently serve as molecular patterns that can quantitatively affect the output of the genetic code in time and space. With the advent of NextGen sequencing platforms in the past 5 years, ChIP-seq together with RNA-seq are techniques that have revolutionize chromatin related research by enabling high resolution mapping of chromatin modifications as well as transcripts produced in a cell. A major challenge in the field is to extract functionally relevant insights from the large quantity of data generated from these high-throughput technologies. In this talk, we will explore two related data integration and visualization approaches, ANCORP and SSEA, that we have used to reveal correlations between chromatin marks and transcript output in Arabidopsis.

問合せ先

植物代謝制御
出村　拓 (demura@bs.naist.jp)