Genome Maintenance in Cancer and Aging
|Title||Genome Maintenance in Cancer and Aging
Dr. Eishi Noguchi
College of Medicine, Drexel University, USA
|Date&Time||12/15/2017 (Fri) 15：00～16：00|
Genomic instability is a hallmark of cancer and age-related diseases. Emerging evidence indicates that a variety of environmental factors and toxins damage DNA, leading to genomic instability; however, the mechanisms by which cells prevent and repair DNA damage are still elusive. Our long-term goal is to understand how cells maintain genomic integrity to regulate lifespan and avoid tumorigenesis.
1. Role of the Timeless protein in telomere maintenance: Timeless is a component of the replication machinery and is involved in accurate genome duplication. We found that Timeless prevents repeat instability at telomeres. We show that Timeless functions as an anti-recombinase to maintain telomere length and integrity.
2. Role of Maf1 in lifespan extension: It is widely known that mTOR regulates lifespan. However, its downstream effectors for lifespan regulation remain elusive. We provide evidence that Maf1 is a critical lifespan regulator downstream of the mTOR pathway. Our results suggest that Maf1-mediated transcriptional regulation prevents genomic instability to extend lifespan.
3. Alcohol-induced DNA damage response: Acetaldehyde, the primary metabolite of alcohol, forms DNA adducts, resulting in genomic instability. We will discuss the role of acetaldehyde in preventing DNA replication process and dysregulating normal DNA damage response in esophageal keratinocytes.
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