English Seminars
From Protein Folding to Cognition: a Serendipitous Path of Discovery
| Title | From Protein Folding to Cognition: a Serendipitous Path of Discovery |
| Lecturer | Dr. Peter Walter (University of California, San Francisco) |
| Language | English |
| Date&Time | 06/06/2017 (Tue) 11：00～12：30 |
| Venue | 大セミナー室 |
| Detail | A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays. |
| Contact | ストレス微生物科学 木俣 行雄 (kimata@bs.naist.jp) |