The complex path to site-specific actions of Focal Adhesion Kinases

Title The complex path to site-specific actions of Focal Adhesion Kinases
Lecturer Dr. Stefan T Arold(King Abdullah University of Science and Technology, Saudi Arabia)
Language English
Date&Time 05/18/2016 (Wed) 15:30~16:30
Venue L12会議室
Detail Focal adhesion kinase (FAK) controls adhesion-dependent cell motility, survival, and proliferation, and plays a major role in development and cancer. Interestingly, FAK has different functions in different cellular compartments. For example at focal adhesions, FAK regulates integrin signalling in a kinase-dependent manner, whereas in the nucleus it exerts kinase-independent anti-apoptotic effects. We have combined SAXS with data from x-ray crystallography, NMR, bioinformatics, biochemical and functional analyses, to provide first structural insights into full-length FAK. Through specifically affecting the structural dynamics of FAK, we show that low-probability conformational transitions are of biological importance. Collectively, our data show how the dynamics and allosteric interplay between ligands and FAK’s several domains controls site-specific activity of FAK. Our results reveal how FAK detects the coincidence of multiple signals to generate an environment-specific outcome, and open novel therapeutic opportunities for blocking cancer cell invasiveness through protein-protein interaction inhibitors.
Contact 発生医科学
笹井 紀明 (

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