English Seminars
Molecular mechanisms of microtubule nucleation and dynamics - studied in reconstituted systems
| Title | Molecular mechanisms of microtubule nucleation and dynamics - studied in reconstituted systems |
| Lecturer | Thomas Surrey PhD (Francis Crick Institute, London, UK) |
| Language | English |
| Date&Time | 11/24/2015 (Tue) 17：00～18：00 |
| Venue | Bio Large Seminar Room |
| Detail | The cytoskeleton is essential for the internal organization of eukaryotic cells. One hallmark of the cytoskeleton is its dynamic nature. Microtubules constantly polymerise and depolymerise. The molecular mechanisms underlying controlled microtubule nucleation and microtubule dynamic instability are still poorly understood. We address these questions using reverse engineered systems, quantitative fluorescence microscopy and image analysis. Here, we will present recent progress in understanding molecular mechanisms of microtubule cytoskeleton dynamics through reverse engineering of dynamic behavior. The focus will be on the regulation of microtubule dynamics and microtubule nucleation. The power of in vitro reconstitutions in combination with fluorescence microscopy will be illustrated in the context of regulatory proteins binding preferentially to dynamic microtubule ends. 参考文献： 1. Roostalu et al., Nat Cell Biol. 2015, doi: 10.1038/ncb3241 2. Maurer et al., Curr Biol. 2014, 24, 372-84. doi: 10.1016/j.cub.2013.12.042 3. Maurer et al., Cell. 2012, 149, 371-82. doi: 10.1016/j.cell.2012.02.049 |
| Contact | 神経システム生物学 稲垣 直之 (ninagaki@bs.naist.jp) |