Endothelial morphogenesis and function during zebrafish development

Title Endothelial morphogenesis and function during zebrafish development
Lecturer Prof. Didier Stainier (The University of California, San Francisco)
Language English
Date&Time 11/16/2010 (Tue) 00:00~
Venue バイオサイエンス研究科 L12会議室

Blood vessels form de novo (vasculogenesis) or upon sprouting of capillaries from pre-existing vessels (angiogenesis).  Using high resolution imaging of zebrafish vascular development we discovered a third mode of blood vessel formation whereby the first embryonic artery and vein, two unconnected blood vessels, arise from a common precursor vessel.  The first embryonic vein formed by selective sprouting of progenitor cells from the precursor vessel, followed by vessel segregation.  These processes were regulated in part by the ligand EphrinB2 and its receptor EphB4, which are expressed in arterial-fated and venous-fated progenitors, respectively, and interact to orient the direction of progenitor migration.  Thus, directional control of progenitor migration drives arterial/venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development.

Contact 分子発生生物学
高橋 淑子 (

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