Outline of Research and Education
In nature, plants cope with a wide range of microbes that reside on the surface of or within plant tissues. Plants disregard or tolerate the presence of these plant-inhabiting endophytic microbes at non-damaging levels, despite an elaborate innate immune system to detect and repel microbes. We hypothesize that plants distinguish pathogens from non-pathogens by sensing “danger” signals (DAMPs) generated upon pathogen challenge in addition to microbial signals (MAMPs). We aim to decipher the molecular principles and mechanisms underlying plant immunity to infectious microbes, with major focuses on signaling crosstalk between MAMP and DAMP receptors, defense-related transcriptional reprogramming and infection strategies of pathogenic and endophytic microbes. We also study the mechanisms by which a subset of endophytic microbes facilitates host adaptation to adverse conditions. We believe that our studies will reveal important insight into general principles of plant-microbe interactions, and thus offer new effective approaches to controlling plant health and growth in sustainable agriculture.
Major Research Topics
- Danger sensing and signaling in plant-microbe interactions
- Transcriptional reprogramming and priming in plant immunity
- Modulation of plant immunity in fluctuating environments
- Endophytic and pathogenic microbes in plants
- Plant-associated microbiomes
- Yasuda, Okada and Saijo, Curr. Opin. Plant Biol., 38, 10-18, 2017.
- Yamada et al., Science, 354,1427-1430, 2016.
- Espinas et al., Front. Plant Sci., 7, 1201, 2016
- Hiruma et al., Cell, 165, 464-474, 2016
- Hacquard et al., Nature Commun., doi: 10.1038/ncomms11362, 2016
- Yamada et al, EMBO J., 35, 46-61, 2016
- Ross et al., EMBO J., 33, 62-75, 2014
- Tintor et al., Proc Natl Acad Sci U.S.A., 110, 6211-6216, 2013
- Serrano et al., Plant Physiol., 158, 408-422, 2012
- Saijo, Cell Microbiol., 12, 716-724, 2010
- Lu et al., Proc Natl Acad Sci USA, 106, 22522-22527, 2009
- Saijo et al., EMBO J., 28, 3439-3449, 2009
- Saijo et al., Mol. Cell, 31, 607-613, 2008
- Shen et al., Science, 315, 1098-1103, 2007