NAIST 奈良先端科学技術大学院大学 バイオサイエンス領域



バイオサイエンス領域 幹細胞工学研究室の髙田仁実助教が第20回梅園賞を受賞しました。


第20回梅園賞受賞者 髙田仁実助教のコメント



Gastric stem cell system protecting healthy gastric mucosa

The lumen of the glandular stomach is covered with a number of invaginated gastric units composed of multiple functional epithelial cells including acid-secreting parietal cells, digestive enzyme-secreting chief cells, and mucus-secreting pit and neck cells. Continuous replenishment of these epithelial cells relies on a population of stem cells within gastric units. Dysregulation of gastric stem cell differentiation is associated with various gastric disorders, including pseudopyloric metaplasia, Ménétrier’s disease, and Zollinger–Ellison syndrome. However, the molecular mechanisms underlying the gastric stem cell differentiation in stomach homeostasis have not been fully elucidated. Here, by utilizing the single-cell RNA sequencing method Quartz-Seq2, we analyzed the gene expression dynamics during gastric stem cell differentiation. Enrichment analysis of pseudotime dependent genes identified that EGFR signaling promotes pit cell differentiation, while TNFSF12 signaling maintains the gastric stem cells in undifferentiated state. Further validation through in vitro gastric organoid assays confirmed the role of these signaling pathway in regulating gastric stem cell differentiation. These findings provide valuable insights into the underlying mechanisms maintaining stomach homeostasis, and form the foundation to understand the pathogenesis of gastric disorders.



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