神経システム生物学研究室

研究業績

最近の主な研究業績

  1. Huang, L., Urasaki, A. and Inagaki N. (2019)
    Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain, Sci. Rep. 9:1799. (LINK)
  2. Minegishi, T., Uesugi, Y., Kaneko, N., Yoshida, W., Sawamoto, K., Inagaki, N. (2018)
    Shootin1b mediates a mechanical clutch to produce force for neuronal migration, Cell Rep 25, 624-639 (LINK)
  3. Baba, K., Yoshida, W., Toriyama, M., Shimada, T., Manning, C.F., Saito, M., Kohno, K., Trimmer, J.S., Watanabe, R., and Inagaki, N. (2018)
    Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance. eLife 2018;7:e34593.(LINK)(Faculty of 1000 prime special significance)
  4. Abe, K., Katsuno, H., Toriyama, M., Baba, K., Mori T., Hakoshima T, Kanemura Y., Watanabe, R. and Inagaki, N. (2018)
    Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis, Proc. Natl. Acad. Sci. USA,115, 2764-2769. (LINK)
  5. Inagaki, N., Katsuno, H. (2017)
    Actin Waves: Origin of Cell Polarization and Migration?, Trends in Cell Biology 27, 515-526 (LINK)
  6. Higashiguchi, Y., Katsuta, K., Minegishi, T., Yonemura, S., Urasaki, A., Inagaki, N. (2016)
    Identification of a shootin1 isoform expressed in peripheral tissues, Cell and Tissue Research 366, 75-87(2016) (LINK)(Get PDF)
  7. Kubo, Y., Baba, K., Toriyama, M., Minegishi, T., Sugiura, T., Kozawa, S., Ikeda, K., and Inagaki, N. (2015)
    Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth. J Cell Biol. 210, 663-676. (LINK)(解説)
  8. Katsuno, H., Toriyama, M., Hosokawa, Y., Mizuno, K., Ikeda, K., Sakumura, Y, and Inagaki, N. (2015)
    Actin migration driven by directional assembly and disassembly of membrane anchored actin filaments, Cell Reports 12, 648-660.(LINK)(解説)(Issue Highlights)
  9. Toriyama, M., Kozawa, S., Sakumura, Y. and Inagaki, N. (2013)
    Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation, Current Biology 23, 529-534 (LINK)(解説)(Faculty of 1000 special significance)
  10. Kozawa, S., Sakumura, Y., Toriyama, M., Inagaki, N., and Ikeda, K. (2013)
    Bayesian Cell Force Estimation Considering Force Directions, Neural Process Lett,41,2,191-200, DOI 10.1007/s11063-013-9320-y
  11. Nakazawa, H., Sada, T., Toriyama, M., Tago, K., Sugiura, T., Fukuda, M. and Inagaki, N. (2012)
    Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth. J. Neurosci. 32, 12712-12725.(LINK)(解説)
  12. Hirano, Y., Hatano, T., Takahashi, A., Toriyama, M., Inagaki, N., and Hakoshima, T.(2011)
    Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain, EMBO J.30, 2734-2747.
  13. Inagaki, N.,Toriyama, M. and Sakumura, Y.(2011)
    Systems biology of symmetry-breaking during neuronal polarity formation, Dev. Neurobiol. 71, 584-593.(LINK)(Get PDF)
  14. Toriyama, M., Sakumura, Y., Shimada, T., Ishii, S. and Inagaki, N.(2010)
    A diffusion-based neurite length sensing mechanism involved in neuronal symmetry-breaking, Mol.Syst.Biol. 6, 394.(LINK) (解説)
  15. Yamatani, H., Kawasaki T., Mita S., Inagaki N. and Hirata T. (2010)
    Proteomics analysis of temporal changes in axonal proteins during maturation, Dev. Neurobiol, Jun;70(7):523-37.
  16. Mori, T., Inagaki, N. and Kamiguchi, H.(2009)
    Neuronal Process Outgrowth, In Lajtha F.W., Mikoshiba, K. (eds): Handbook of Neurochemistry and Molecular Neurobiology, Springer-Verlag, pp40-44.
  17. Shimada, T., Toriyama, M., Uemura, K., Kamiguchi, H., Sugiura, T., Watanabe, N. and Inagaki, N. (2008)
    Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth., J. Cell Biol. 181, 817-829.(LINK) (解説)
  18. Mori, T., Wada, T., Suzuki, T., Kubota, Y.and Inagaki, N. (2007)
    Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity, J. Biol. Chem. 282, 19884-19893.(LINK) (解説) (Faculty of 1000 Exceptional)
  19. Toriyama, M., Shimada, T., Kim, K-B., Mitsuba, M., Nomura, E., Katsuta, K., Sakumura, Y., Roepstorff, P., and Inagaki, N. (2006)
    Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization.J. Cell Biol. 175, 147-157.(LINK) (解説)
  20. Katano, T., Mabuchi, T., Okuda-Ashitaka, E., Inagaki, N., Kinumi, T. and Ito, S. (2006)
    Proteomic identification of a novel isoform of collapsin response mediator protein (CRMP-2) in spinal nerves peripheral to dorsal root ganglia, Proteomics 8, 6085-6094.
  21. Nomura, E., Katsuta, K., Ueda, T., Toriyama, M., Mori, T. and Inagaki, N. (2004)
    Acid-labile surfactant Improves In-solution dodecyl sulfate polyacrylamide gel protein digestion for matrix-assisted laser desorption/ionization mass spectrometric peptide mapping, J. Mass Spectrometry 39, 666-672.
  22. Inagaki, N. and Katsuta, K. (2004)
    Large gel two-dimensional electrophoresis: improving recovery of cellular proteome, Curr. Proteomics 1, 35-39.
  23. Suzuki, Y., Nakagomi, S., Namikawa, K., Kiryu-Seo, S., Inagaki, N., Kaibuchi, K., Aizawa, H., Kikuchi, K., and Kiyama, H. (2003)
    Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured moter neurons of rat, J. Neurochem. 86, 1042-1050.
  24. Oguri, T., Takahata, I., Katsuta, K., Nomura, E., Hidaka, M. and Inagaki, N. (2002)
    Proteome analysis of rat hippocampal neurons by multiple large gel two-dimensional electrophoresis, Proteomics 2, 666-672.
  25. Inagaki, N., Katsuta, K., Nomura, E., Ueda, T., Toriyama, M., and Mori, T. (2002)
    High resolution large gel two-dimensional electrophoresis for proteomics, BIOforun Int. 6, 324-325.
  26. Fukata, Y., Itoh T.J., Kimura T., Menager C., Nishimura, T., Shiromizu, T., Watanabe, H., Inagaki, N., Iwamatsu, A., Hotani, H. and Kaibuchi, K. (2002)
    CRMP-2 binds to tubulin heterodimers to promote microtubule assembly, Nature Cell Biol. 4, 583-591
  27. Inagaki, N., Chihara, K., Arimura, N., Menager, C., Kawano, Y., Matsuo, N., Nishimura, T., Amano, M. and Kaibuchi, K. (2001)
    CRMP-2 induces Axons in Cultured Hippocampal Neurons. Nature Neurosci. 4, 781-782.
  28. Canossa, M., Gartner, A., Campana, G., Inagaki, N. and Thoenen, H. (2001)
    Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI)- and Trk-receptor activation is mediated via phospholipase C signaling pathways, EMBO J. 20, 1641-1650.
  29. Taya, S., Inagaki, N., Sengiku, H., Makino, H., Iwamatsu, A., Urakawa, I., Nagano, K., Kataoka, S. and Kaibuchi, K. (2001)
    Direct Interaction of Insulin-like growth factor-1 receptor with leukemia-associated RhoGEF, J. Cell Biol.,155, 809-819.
  30. Arimura, N., Inagaki, N., Chihara, K., Menager, C., Nakamura, N., Amano, M., Iwamatsu, A., Goshima, Y. and Kaibuchi, K. (2000)
    Phosphorylation of Collapsin Response Mediator Protein-2 by Rho-kinase: Evidence for Two Separate Signaling Pathways for Growth Cone Collapse. J. Biol. Chem. 275, 23973-23980.
  31. Inagaki, N., Nishizawa, M., Arimura, N., Yamamoto, H., Takeuchi, Y., Miyamoto, E., Kaibuchi, K.and Inagaki, M. (2000)
    Activation of Ca2+/calmodulin-dependent Protein Kinase II within Post-synaptic Dendritic Spines of Cultured Hippocampal Neurons. J. Biol. Chem. 275, 27165-27171.
  32. Ming, G.-i., Song, H.-j., Berninger, B., Inagaki, N., Tessier-Lavine, M. and Poo, M.-m. (1999)
    Phospholipase C-g and phosinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, 139-148.
  33. 稲垣直之(2019)
    Shootin1による細胞-基質間の力の発生を介した神経細胞の細胞移動,極性形成,軸索ガイダンスおよびアクチン波,生化学,91, 159-168
  34. 勝野弘子, *稲垣直之(2016)
    神経細胞極性, (脳科学辞典(林康紀 他編)),DOI:10.14931/bsd.7001
  35. 馬場健太郎, 浦崎明宏, 稲垣直之(2014)
    ラージゲルプロテオミクスを基盤とした神経細胞の軸索形成とガイダンスの解析,電気泳動,第58巻第2号,49-52(Get PDF)
  36. 稲垣直之 (2013)
    ニュー ロンの極性化を担う細胞内シグナル経路,脳の発生学(宮田卓樹, 山本亘彦 編),化学同人, 72-89
  37. 久保祐亮, *稲垣直之 (2012)
    CRMP2,(脳科学辞典(田中啓治, 御子柴克彦 編))
  38. 吉田亙, 鳥山道則, *稲垣直之,(2012)
    プロテオミクスを基礎にした神経細胞が非対称性を獲得する機構の解析, 生物物理化学 56:31
  39. 鳥山道則, 作村諭一,稲垣直之(2011)
    神経細胞が突起の長さを検知する仕組みと神経細胞の対称性の破れ,遺伝 65, 80-86
  40. 鳥山道則, 稲垣直之(2010)
    ニューロンにはアクソンは1本しかないのか?,Clinical Neuroscience 28, 113
  41. 稲垣直之, 鳥山道則, 島田忠之 (2007)
    神経極性形成とShootin1のフィードバックループ,生化学 79, 799-802
  42. 稲垣直之, 鳥山道則, 島田忠之 (2007)
    Shootin1による神経細胞の対称性破壊と極性形成,脳21,10, 107-109
  43. 稲垣直之(2005)
    二次元電気泳動法をベースとしたプロテオミクスの高感度化,遺伝子医学 MOOK 「疾患プロテオミクスの最前線」, 76-81,メディカルドウ
  44. 稲垣直之(2002)
    ポストシナプス・樹状突起スパインにおけるCaMKIIの空間的シグナリング,生体の科学 54(2) 90-96
  45. 稲垣直之,稲垣昌樹(2003)
    動くシナプスと神経ネットワーク(塩坂貞夫 編),金芳堂,p103-110
  46. 稲垣直之(2002)
    細胞内の空間シグナル,細胞工学 21 (4) 345
  47. 勝田和大,野村英子,稲垣直之(2002)
    Multiple large gel two-dimensional electrophoresis for proteomics, Jap. J. Electrophresis 47, 27-31
  48. 稲垣直之(2002)
    高解像度ラージゲルを用いた二次元電気泳動法による細胞内発現蛋白質の網羅的検出,実験医学 21(1),85-88
  49. 稲垣直之,貝淵弘三(2001)
    CRMP-2は海馬神経細胞の軸索形成を誘導する,細胞工学 20 (10), 1408-1409
  50. 稲垣直之,貝淵弘三(2001)
    神経細胞の軸索および極性形成の分子機構,生体の科学52(3),230- 234
  51. 稲垣直之,貝淵弘三(1999)
    RhoファミリーGTPaseによる神経成長円錐と軸索ガイダンスの調節、脳・神経科学の最前線 実験医学 17, 2093-2096.

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神経システム生物学研究室

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