Animals move and change their shape, using force generated by muscles. How cells do so? Actin polymerizes near the leading edges of neurite tips and migrating cells. We reported that shootin1a interacts with both the polymerizing actin filaments and the cell adhesion molecule L1-CAM at neurite tips, thereby generating traction force for neurite outgrowth. We are currently analyzing molecular mechanisms for generation and regulation of mechanical forces for axon guidance and neuronal migration. We also reported a new type of axon guidance mechanism (Grip & Slip mechanism) induced by the extracellular matrix protein Laminin.

Traction force microscopy to measure forces for axon guidance and neuronal migration

Reference

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