Research outcomes
Mizuki Asada from the Laboratory of Microbial interaction has received the Hot Topics Award at The 2025 Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
Mizuki Asada from the Laboratory of Microbial interaction has received the Hot Topics Award at The 2025 Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
Comment on the Award
I am truly honored to receive this award. I sincerely appreciate the guidance of my professors and will continue to strive for excellence.
Title of the awarded research
Elucidation of new adaptation mechanisms of various yeasts in high-temperature environments
Detail of the awarded research
Organisms can only grow within specific temperature ranges, and growth is severely inhibited under high-temperature environments that exceed the upper growth limit. We recently reported that, in the presence of rapamycin, an inhibitor of TORC1, Schizosaccharomyces pombe can proliferate at high temperatures that usually arrest its growth. TORC1 is a complex composed of multiple regulatory subunits centered around the serine/threonine kinase TOR, which is highly conserved from yeast to humans. Although TORC1 typically promotes cell growth, our findings suggest that it suppresses growth at high temperatures. In this study, we aimed to determine if this mechanism is conserved across other species by conducting experiments on some species of fission yeasts and on budding yeasts S. cerevisiae. Our results demonstrated that rapamycin treatment promotes growth at high temperatures across all tested yeasts. The gene deletion mutants of TORC1 pathway factors (Gtr1, Tor1, Sch9) in S. cerevisiae exhibited even more enhanced growth at high temperatures than WT cells. These findings indicate that the Gtr1-TORC1-Sch9 pathway contributes to suppressing growth at high temperatures.
Microbial interaction
https://bsw3.naist.jp/courses/courses313.html
https://bsw3.naist.jp/microbial_interaction/
( April 01, 2025 )
