NAIST 奈良先端科学技術大学院大学 バイオサイエンス領域

セミナー情報

Microtubules Gate Tau Condensation To Spatially Regulate Diverse Microtubule Functions

演題 Microtubules Gate Tau Condensation To Spatially Regulate Diverse Microtubule Functions
講演者 Dr. Richard Mckenney
(Department of Molecular and Cellular Biology, College of Biological Sciences, University of California Davis)
使用言語 英語
日時 2019年12月17日(火曜日) 13:30~14:30
場所 Large seminar room (C109) 
内容
Tau is an abundant microtubule-associated protein (MAP) in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer’s disease and other dementias, yet the physiological state of tau molecules within cells remains unclear. Using single molecule imaging, we directly observe that the microtubule lattice regulates reversible tau self-association, leading to localized, dynamic condensation of tau molecules on the microtubule surface. Tau condensates form selectively permissible barriers, spatially regulating the activity of microtubule severing enzymes and the movement of molecular motors through their boundaries. We propose that reversible self-association of tau molecules, gated by the microtubule lattice, is an important mechanism of tau’s biological functions, and that oligomerization of tau is a common property shared between the physiological and disease forms of the molecule. Further, we find that microtubule-gated condensation is an evolutionary acquisition within the tau-family of MAPs, suggesting specialization of function.
問合せ先 RNA分子医科学研究室
岡村 勝友教授 (okamurak@bs.naist.jp)

一覧へ戻る