Nara Institute of Science and Technology
Graduate School of Science and Technology, Division of Biological Science

Organ Developmental Engineering -Isotani Lab-

Xenogeneic chimeras provide new findings

  1. Until the 8-cell stage, fertilized embryos have the potential to differentiate into any type of organ.
  2. The blastocyst consists of an inner cell mass (ICM), which subsequently forms the fetus, and the trophoblast, which develops into placenta.
  3. Embryonic stem (ES) cells, which originate from the ICM, have the potential to differentiate into a wide range of organs and tissues, with the exception of placenta.
  4. Injection of rat-derived ES cells into mouse blastocysts can generate an interspecies chimeric animal that harbors cells of both rat and mouse origin.


  • 2022-10-14
    A new M1 sutudent joined in our Lab. (go to Members page).
  • 2022-03-16
    Hirata-kun's reserch data was selected the cover of Experimental Animals (go to Events page).
  • 2022-03-09
    Yuri-san won the the Award for Excellence at JXA (go to Events page).
  • 2017-03-1
    The website has been released since March 1st 2017.

About the Isotani Laboratory