NAIST 奈良先端科学技術大学院大学 バイオサイエンス領域



バイオサイエンス領域 花発生分子遺伝学研究室 山口暢俊助教が今年度のバイオ領域賞を受賞しました。

バイオ領域賞は、バイオサイエンス領域所属の若手教員の本学での優れた研究を顕彰し、さらなる飛躍発展を願うために、平成30年度までのNAISTバイオ学術賞に変わり、平成31(令和元)年度から、この名称に変更になりましたが、本学で行った研究を対象として、候補者を自薦、他薦により募集し、推薦された候補者の業績調書に基づいて、領域賞選考委員会において、原則1 名の受賞者を選考するものです。受賞対象者は、准教授(ただし、独立准教授は除く)および助教とし、概ね過去5~10年間の教員としての研究業績をもとに評価しております。受賞者には表彰状と本学支援財団からの賞金を含む副賞が授与されました。


Epigenetic regulation of gene expression controls flower development and environmental responses in Arabidopsis thaliana

In a multicellular organism, cells are genetically homogenous but functionally heterogeneous due to the differential gene expression. Many of these differences in gene expression arise during development and in response to environmental cues. Epigenetics is the study of how cells control gene expression without changing the DNA sequence. Epigenetic researches usually include investigation of nuclear organization, DNA methylation, histone modification, and RNA transcription. Although a lot of epigenetic regulations are known in animals, the regulatory mechanisms underlying plant development and environmental responses are not fully understood.
Since 2015 when I joined NAIST as Assistant Professor, I have consistently investigated the roles of genes that involve in epigenetic regulations in plants. By making full use of biochemistry and bioinformatics approaches, as well as molecular genetic methods using various mutants in Arabidopsis thaliana, my research has elucidated gene regulatory networks underlying flower development and environmental responses. In this presentation, I will introduce my research over the years, with my deepest appreciation to my supervisor and key students at NAIST, as well as all the collaborators in Japan and overseas.

  • Yamaguchi et al. (2021) H3K27me3 demethylases alter HSP22 and HSP17.6C expression in recurring heat in Arabidopsis. Nature Communications 12, 3480.
  • Pelayo et al. (2021) One factor many systems: The floral homeotic protein AGAMOUS and its epigenetic regulatory mechanism. Current Opinion in Plant Biology 61, 102009. 
  • Zhu et al. (2020) TERMINAL FLOWER1-FD complex target genes and competition with FLOWERING LOCUS T. Nature Communications 11, 5118.
  • Wu et al. (2019) Abscisic acid-dependent histone demethylation during postgermination growth arrest in Arabidopsis. Plant Cell and Environment 42, 2198-2214.
  • Yamaguchi et al. (2018) Chromatin-mediate feed forward auxin biosynthesis in floral meristem determinacy. Nature Communications 9, 1.
  • Yamaguchi et al. (2017) Fine-tuning of auxin homeostasis governs the transition from floral stem cell maintenance to gynoecium formation. Nature Communications 8, 1125. 



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