Suetsugu, S., H. Miki, and T. Takenawa, The essential role of profilin in the assembly of actin for microspike formation. EMBO J., 1998. 17: p. 6516-6526.
Miki, H., S. Suetsugu, and T. Takenawa, WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J., 1998. 17: p. 6932-6941.
Suetsugu, S., H. Miki, and T. Takenawa, Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with Arp2/3 complex. Biochem. Biophys. Res. Commun., 1999. 260(1): p. 296-.
Suetsugu, S., H. Miki, and T. Takenawa, Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis. FEBS Lett, 1999. 457(3): p. 470-4.
Miki, H., H. Yamaguchi, S. Suetsugu, and T. Takenawa, IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature, 2000. 408: p. 732-735.
Mimuro, H., T. Suzuki, S. Suetsugu, H. Miki, T. Takenawa, and C. Sasakawa, Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri. J Biol Chem, 2000. 275: p. 28893-901.
Yamaguchi, H., H. Miki, S. Suetsugu, L. Ma, M.W. Kirschner, and T. Takenawa, Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proc Natl Acad Sci U S A, 2000. 97: p. 12631-6.
Fukuoka, M., S. Suetsugu, H. Miki, K. Fukami, T. Endo, and T. Takenawa, A Novel Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Binding Protein, WISH, Induces Arp2/3 Complex Activation Independent of Cdc42. J Cell Biol, 2001. 152(3): p. 471-482.
Suetsugu, S., H. Miki, H. Yamaguchi, and T. Takenawa, Requirement of the Basic Region of N-WASP/WAVE2 for Actin-Based Motility. Biochem. Biophys. Res. Commun., 2001. 282: p. 739-744.
Suetsugu, S., H. Miki, and T. Takenawa, Identification of another Actin-related protein (Arp) 2/3 complex binding site in Neural Wiskott-Aldrich syndrome protein (N-WASP), that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J Biol Chem, 2001. 276(35): p. 33175-80.
Suetsugu, S., H. Miki, H. Yamaguchi, T. Obinata, and T. Takenawa, Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2. J. Cell Sci., 2001. 114(24): p. 4533-42.
Fujiwara, I., S. Suetsugu, S. Uemura, T. Takenawa, and S. Ishiwata, Visualization and force measurement of branching by Arp2/3 complex and N-WASP in actin filament. Biochem Biophys Res Commun, 2002. 293(5): p. 1550-5.
Suetsugu, S., M. Hattori, H. Miki, T. Tezuka, T. Yamamoto, K. Mikoshiba, and T. Takenawa, Sustained Activation of N-WASP through Phosphorylation Is Essential for Neurite Extension. Dev Cell, 2002. 3(5): p. 645-58.
Suzuki, T., H. Mimuro, S. Suetsugu, H. Miki, T. Takenawa, and C. Sasakawa, Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell Microbiol, 2002. 4(4): p. 223-33.
Sawa, M., S. Suetsugu, A. Sugimoto, H. Miki, M. Yamamoto, and T. Takenawa, Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure. J Cell Sci, 2003. 116(Pt 8): p. 1505-18.
Suetsugu, S., D. Yamazaki, S. Kurisu, and T. Takenawa, Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev Cell, 2003. 5(4): p. 595-609.
Sun, P., H. Yamamoto, S. Suetsugu, H. Miki, T. Takenawa, and T. Endo, Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem, 2003. 278(6): p. 4063-71.
Yamazaki, D., S. Suetsugu, H. Miki, Y. Kataoka, S. Nishikawa, T. Fujiwara, N. Yoshida, and T. Takenawa, WAVE2 is required for directed cell migration and cardiovascular development. Nature, 2003. 424(6947): p. 452-6.
Kawamura, K., K. Takano, S. Suetsugu, S. Kurisu, D. Yamazaki, H. Miki, T. Takenawa, and T. Endo, N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor. J Biol Chem, 2004. 279(52): p. 54862-71.
Kurisu, S., S. Suetsugu, D. Yamazaki, H. Yamaguchi, and T. Takenawa, Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells. Oncogene, 2004.
Mizutani, K., S. Suetsugu, and T. Takenawa, FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. Biochem Biophys Res Commun, 2004. 313(3): p. 468-74.
Oikawa, T., H. Yamaguchi, T. Itoh, M. Kato, T. Ijuin, D. Yamazaki, S. Suetsugu, and T. Takenawa, PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol, 2004. 6(5): p. 420-6.
Suetsugu, S., T. Tezuka, T. Morimura, M. Hattori, K. Mikoshiba, T. Yamamoto, and T. Takenawa, Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J, 2004. 384(Pt 1): p. 1-8.
Wu, X., S. Suetsugu, L.A. Cooper, T. Takenawa, and J.L. Guan, Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem, 2004. 279(10): p. 9565-76.
Oda, A., H. Miki, I. Wada, H. Yamaguchi, D. Yamazaki, S. Suetsugu, M. Nakajima, A. Nakayama, K. Okawa, H. Miyazaki, K. Matsuno, H.D. Ochs, L.M. Machesky, H. Fujita, and T. Takenawa, WAVE/Scars in platelets. Blood, 2005. 105(8): p. 3141-8.
Park, S.J., S. Suetsugu, and T. Takenawa, Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. Embo J, 2005 Apr 20;24(8):1557-70.
Yamazaki D, Fujiwara T, Suetsugu S, Takenawa T A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading. Genes Cells. 2005 10(5):381-92.
Mizutani K, Koike D, Suetsugu S, Takenawa T. WAVE3 functions as a negative regulator of LDOC1. J Biochem (Tokyo). 2005;138(5):639-46.
Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol. 2006 Jan 16;172(2):269-79.
Mitsushima M, Sezaki T, Akahane R, Ueda K, Suetsugu S, Takenawa T, Kioka N. Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. Genes Cells. 2006;11(3):281-92.
Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, Takenawa T. Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol. 2006 May 22;173(4):571-85. Epub 2006 May 15.
Suetsugu S, Murayama K, Sakamoto A, Hanawa-Suetsugu K, Seto A, Oikawa T, Mishima C, Shirouzu M, Takenawa T, Yokoyama S. The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem. 2006 Nov 17;281(46):35347-58. Epub 2006 Sep 25.
Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T. Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex. J Biochem (Tokyo). 2007 Mar;141(3):319-25. Epub 2007 Jan 3.
Shimada A*, Niwa H*, Tsujita K*, Suetsugu S*, Nitta K, Hanawa-Suetsugu K, Akasaka R, Nishino Y, Toyama M, Chen, Liu Z-J, Wang B-C, Yamamoto M, Terada T, Miyazawa A, Shirouzu M, Tanaka A, Sugano S, Nagayama K, Takenawa T, Yokoyama S. Gently-curved EFC-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell 2007 18 May; 129:761-772 (* equal contribution)
Park SJ, Suetsugu S, Sagara H, Takenawa T. HSP90 cross-links branched actin filaments induced by N-WASP and the Arp2/3 complex. Genes Cells. 2007 ;12(5):611-22.
Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P. Synaptopodin Protects Against Proteinuria by Disrupting Cdc42:IRSp53:Mena Signaling Complexes in Kidney Podocytes. Am J Pathol. 2007; 171, 415-27.
Suetsugu S, Banzai Y, Kato M, Fukami K, Kataoka Y, Takai Y, Yoshida N, Takenawa T. Male-specific sterility caused by the loss of CR16. Genes Cells. 2007 Jun;12(6):721-33.
Uezu A, Horiuchi A, Kanda K, Kikuchi N, Umeda K, Tsujita K, Suetsugu S, Araki N, Yamamoto H, Takenawa T, Nakanishi H. SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15. J Biol Chem. 2007; 282, 26481-9.
Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood. 2007 110, 3637-47 (2007).
Yamashita, M., Higashi, T., Suetsugu, S., Sato, Y., Ikeda, T., Shirakawa, R., Kita, T., Takenawa, T., Horiuchi, H., Fukai, S. Nureki, O. Crystal structure of human DAAM1 formin homology 2 domain. Genes Cells; 12, 1255-65 (2007).
Reviews and Books
Suetsugu, S., H. Miki, and T. Takenawa, Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins. Cell Motil Cytoskeleton, 2002. 51(3): p. 113-22.
Suetsugu, S. and T. Takenawa, Regulation of cortical actin networks in cell migration. Int Rev Cytol, 2003. 229: p. 245-86.
Takenawa, T. and Suetsugu, S. Role of WASp family proteins in Cytoskeletal Reorganization and Cell Motility Edited by Anne Ridely, Michelle Peckham, and Peter Clark, John Wiley and Sons, Ltd, 2004, pp153-164
Suetsugu S, Takenawa T. Previews: Stress-Associated MAP Kinase Fills in the Map of Filamin-Mediated Neuronal Migration. Dev Cell 2007 12; 3-4.
Takenawa T, Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nature Reviews Mol Cell Biol. 2007 8; 37-48.
