Publications
Original articles
- Le QG, Ishiwata-Kimata Y, Kohno K, Kimata Y.
“Cadmium impairs protein folding in the endoplasmic reticulum and induces the unfolded protein response.”
FEMS Yeast Res.Vol.16, fow049, 2016
https://www.ncbi.nlm.nih.gov/pubmed/27298227 - Mathuranyanon R, Tsukamoto T, Takeuchi A, Ishiwata-Kimata Y, Tsuchiya Y, Kohno K, Kimata Y.
“Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain.”
J. Cell Sci.Vol.128, 1762-172, 2015
https://www.ncbi.nlm.nih.gov/pubmed/25770101 - Mochizuki T, Kimata Y, Uemura S, Abe F.
“Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae.”
FEMS Yeast Res.Vol.15, fov044, 2015
https://www.ncbi.nlm.nih.gov/pubmed/26071436 - Miyagawa D, Ishiwata-Kimata Y, Kohno K, Kimata Y
“Ethanol stress impairs protein folding in the endoplasmic reticulum and activates Ire1 in Saccharomyces cerevisiae.”
Biosci. Biotechnol. Biochem.
Vol.78,1389-1391, 2014
https://www.ncbi.nlm.nih.gov/pubmed/25130742 - Ishiwata-Kimata Y, Yamamoto YH, Takizawa K, Kohno K, Kimata Y
F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1.
Cell Struct. Funct. Vol.38, 135-143. 2013
https://www.ncbi.nlm.nih.gov/pubmed/23666407 - Ishiwata-Kimata Y, Promlek T, Kohno K, Kimata Y
“BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response.”
Genes Cells Vol.18, 288-301, 2013
https://www.ncbi.nlm.nih.gov/pubmed/23387983 - Nguyen TSL, Kohno K, Kimata Y
“Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms.”
Biosci. Biotechnol. Biochem. Vol. 77, 1337-1339, 2013
https://www.ncbi.nlm.nih.gov/pubmed/23748779 - Promlek T, Ishiwata-Kimata Y, Shido M, Sakuramoto M, Kohno K,※Kimata Y
“Membrane aberrancy and unfolded aroteins activate the endoplasmic reticulum-stress sensor Ire1 by different manners.”
Mol. Biol. Cell Vol.22, 3520-3532, 2011
https://www.ncbi.nlm.nih.gov/pubmed/21775630 - Yanagitani K, Kimata Y, Kadokura H, Kohno K
“Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.”
Science Vol.331, 586-589, 2011
https://www.ncbi.nlm.nih.gov/pubmed/21233347 - Yamamoto YH, Kimura T, Momohara S, Takeuchi M, Tani T, Kimata Y, Kadokura H, Kohno K
“A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.”
Cell Struct. Funct. Vol.35, 107-116, 2010
https://www.ncbi.nlm.nih.gov/pubmed/21150129 - Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y, Kohno K
“Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.”
Mol. Cell Vol.34, 191-200, 2009
https://www.ncbi.nlm.nih.gov/pubmed/19394296 - Oikawa D, Kimata Y, Kohno K, Iwawaki T
“Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.”
Exp. Cell Res. Vol. 315, 2496-2504. 2009
https://www.ncbi.nlm.nih.gov/pubmed/19538957 - Takeuchi M, Kimata Y, Kohno K
“Saccharomyces cerevisiae Rot1 Is an Essential Molecular Chaperone in the Endoplasmic Reticulum.”
Mol. Biol. Cell Vol.19, 3514-3525, 2008
https://www.ncbi.nlm.nih.gov/pubmed/18508919 - Kimata Y, Ishiwata-Kimata Y, Ito T, Hirata A, Suzuki T, Oikawa D, Takeuchi M, Kohno K
“Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins.”
J. Cell Biol. Vol.179, 75-86, 2007
https://www.ncbi.nlm.nih.gov/pubmed/17923530 - Kimura Y, Saito M, Kimata Y, Kohno K
“Transgenic mice expressing a fully nontoxic diphtheria toxin mutant, not CRM197 mutant, acquire immune tolerance against diphtheria toxin.”
J. Biochem. Vol.142, 105-112, 2007
https://www.ncbi.nlm.nih.gov/pubmed/17522091 - Oikawa D, Kimata Y, Kohno K
“Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.”
J. Cell Sci.
Vol.120, 1681-1688, 2007
https://www.ncbi.nlm.nih.gov/pubmed/17452628 - Takeuchi M, Kimata Y, Hirata A, Oka M, Kohno K
“Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding.”
J. Biochem. Vol.139, 597-605, 2006
https://www.ncbi.nlm.nih.gov/pubmed/16567426 - Kimata Y, Ishiwata-Kimata Y, Yamada S, Kohno K
“Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins.”
Genes Cells. Vol.11, 59-69, 2006
https://www.ncbi.nlm.nih.gov/pubmed/16371132 - Oikawa D, Kimata Y, Takeuchi M, Kohno K
“An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1.”
Biochem J. Vol.391, 135-142, 2005
https://www.ncbi.nlm.nih.gov/pubmed/15954865 - Kimata Y, Oikawa D, Shimizu Y, Ishiwata-Kimata Y, Kohno, K
“A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.”
J. Cell Biol. Vol.167, 445-456, 2004
https://www.ncbi.nlm.nih.gov/pubmed/15520230 - Kimata Y, Kimata YI, Shimizu Y, Abe H, Farcasanu IC, Takeuchi M, Rose MD, Kohno K
“Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.”
Mol. Biol. Cell Vol.14, 2559-2569, 2003
https://www.ncbi.nlm.nih.gov/pubmed/12808051 - Ohdate H, Lim CR, Kokubo T, Matsubara K, Kimata Y, Kohno K
“Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth.”
J. Biol. Chem. Vol.278, 14647-14656, 2003
https://www.ncbi.nlm.nih.gov/pubmed/12576485 - Hosoda A, Kimata Y, Tsuru A, Kohno K
“JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.”
J. Biol. Chem. Vol.278, 2669-2676 2003
https://www.ncbi.nlm.nih.gov/pubmed/12446677 - Fujioka Y, Kimata Y, Nomaguchi K, Watanabe K, Kohno K
“Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5/SMC6 complex involved in DNA repair.”
J. Biol. Chem. Vol.277, 21585-21591, 2002
https://www.ncbi.nlm.nih.gov/pubmed/11927594 - Okushima Y, Koizumi N, Yamaguchi Y, Kimata Y, Kohno K, Sano H
Isolation and Characterization of a Putative Transducer of Endoplasmic Reticulum Stress in Oryza sativa.”
Plant Cell Physiol. Vol.43, 532-539, 2002
https://www.ncbi.nlm.nih.gov/pubmed/12040100 - Koizumi N, Martinez I, Kimata Y, Kohno K, Sano H, Chrispeels MJ
“Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum located transmembrane protein kinases.”
Plant Physiol.Vol.127, 949-962, 2001
https://www.ncbi.nlm.nih.gov/pubmed/11706177 - Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, Mekada E, Kimata Y, Tsuru A, Kohno K
“Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice.”
Nature Biotechnol.Vol.19, 746-750, 2001
https://www.ncbi.nlm.nih.gov/pubmed/11479567 - Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K
“Translation control by ER transmembrane kinase/ribonuclease IRE1 under ER stress.”
Nature Cell Biol.Vol.3, 158-164, 2001
https://www.ncbi.nlm.nih.gov/pubmed/11175748 - Kimata Y, Ooboki K, Nomura-Furuwatari C, Hosoda A, Tsuru A, Kohno K
“Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search.”
Gene Vol.261, 321-327, 2000
https://www.ncbi.nlm.nih.gov/pubmed/11167020 - Yoshizawa F, Miura Y, Tsurumaru K, Kimata Y, Yagasaki K, Funabiki R
“Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation.”
Biosci. Biotechnol. Biochem. Vol.64, 2482-2485, 2000
https://www.ncbi.nlm.nih.gov/pubmed/11193422 - Okamura K, Kimata Y, Higashio H, Tsuru A, Kohno K
“Dissociation of Kar2p/BiP from an endoplasmic reticulum sensory molecule, Ire1p, triggers unfolded protein response in yeast.”
Biochem. Biophys. Res. Commun.Vol.279, 445-450, 2000
https://www.ncbi.nlm.nih.gov/pubmed/11118306 - 32. Lim CR, Kimata Y, Ohdate H, Kokubo T, Kikuchi N, Horigome T, Kohno K
“The Saccharomyces cerevisiae RuvB-like protein, Tih2p is required for cell cycle progression.”
J. Biol. Chem.Vol.275, 22409-22417, 2000
https://www.ncbi.nlm.nih.gov/pubmed/10787406 - Higashio H, Kimata Y, Kiriyama T, Hirata A, Kohno K
“Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum.”
J. Biol. Chem.Vol.275, 17900-17908, 2000
https://www.ncbi.nlm.nih.gov/pubmed/10749860 - Kimata Y, Higashio H, Kohno K
“Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP.”
J. Biol. Chem.Vol.275, 10655-10660, 2000
https://www.ncbi.nlm.nih.gov/pubmed/10744762 - Kimata Y, Lim CR, Kiriyama T, Nara A, Hirata A, Kohno K
“Mutation of the yeast epsilon-COP gene ANU2 causes abnormal nuclear morphology and defects in intracellular vesicular transport.”
Cell Struct. Funct.Vol.24, 197-208, 1999
https://www.ncbi.nlm.nih.gov/pubmed/10532354 - Oka M, Nakai M, Endo T, Lim CR, Kimata Y, Kohno K
“Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae.”
J. Biol. Chem. Vol.273, 29727-29737, 1998
https://www.ncbi.nlm.nih.gov/pubmed/9792686 - Kimata Y, Iwaki M, Lim CR, Kohno K
“A novel mutation which enhances the fluorescence of green fluorescent protein at high temperatures.”
Biochem. Biophys. Res. Commun.Vol.232, 69-73, 1997
https://www.ncbi.nlm.nih.gov/pubmed/9125154 - Oka M, Kimata Y, Mori K, Kohno K
“Saccharomyces cerevisiae KAR2 (BiP) gene expression is induced by loss of cytosolic HSP70/Ssa1p through a heat shock element-mediated pathway.”
J. Biochem. Vol.121, 578-584, 1997
https://www.ncbi.nlm.nih.gov/pubmed/9133628 - Lim CR, Kimata Y, Oka M, Nomaguchi K, Kohno K
“Thermosensitivity of green fluorescent protein fluorescence utilized to reveal novel nuclear-like compartments in a mutant nucleoporin NSP1.”
J. Biochem. Vol.118, 13-17 1995
https://www.ncbi.nlm.nih.gov/pubmed/8537302 - Kimata Y, Kohno K
“Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth.”
J. Biol. Chem.Vol.269, 13497-134501 1994
https://www.ncbi.nlm.nih.gov/pubmed/8175783 - Kimata Y, Harashima S, Kohno K
“Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae.”
Biochem. Biophys. Res. Commun. Vol.191, 1145-1151 1993
https://www.ncbi.nlm.nih.gov/pubmed/8466491 - Masui M, Tsuchida K, Kimata Y, Ozaki S
“Epoxidation catalyzed by manganese(III) tetraphenylporphyrin chloride using dioxygen activated by a novel system containing N-hydroxyphthalimide and styrene.”
Chem. Pharm. Bull. Vol.35, 3078-3081, 1987
Reviews, etc
English
- Oikawa D, Kimata Y
“Experimental approaches for elucidation of stress-sensing mechanisms of the Ire1 family proteins.”
Methods Enzymol. Vol.490, 195-216, 2011 - Kimata Y, Kohno K
“Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cellsh”
Curr. Opp. Cell. Biol. Vol.23, 135-142, 2011
https://www.ncbi.nlm.nih.gov/pubmed/21093243 - Takeuchi M, Kimata Y, Kohno K
“Causal links between protein folding in the ER and events along the secretory pathway.”
Autophagy Vol.2, 323-324, 2006
https://www.ncbi.nlm.nih.gov/pubmed/16874095 - Kimata Y, Lim CR, Kohno K
“S147P green fluorescent protein: a less thermosensitive green fluorescent protein variant.”
Methods Enzymol. Vol.302, 373-378, 1999
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