Publications

Original articles

  1. Le QG, Ishiwata-Kimata Y, Kohno K, Kimata Y.
    “Cadmium impairs protein folding in the endoplasmic reticulum and induces the unfolded protein response.”
    FEMS Yeast Res.Vol.16, fow049, 2016
    https://www.ncbi.nlm.nih.gov/pubmed/27298227
  2. Mathuranyanon R, Tsukamoto T, Takeuchi A, Ishiwata-Kimata Y, Tsuchiya Y, Kohno K, Kimata Y.
    “Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain.”
    J. Cell Sci.Vol.128, 1762-172, 2015
    https://www.ncbi.nlm.nih.gov/pubmed/25770101
  3. Mochizuki T, Kimata Y, Uemura S, Abe F.
    “Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae.”
    FEMS Yeast Res.Vol.15, fov044, 2015
    https://www.ncbi.nlm.nih.gov/pubmed/26071436
  4. Miyagawa D, Ishiwata-Kimata Y, Kohno K, Kimata Y
    “Ethanol stress impairs protein folding in the endoplasmic reticulum and activates Ire1 in Saccharomyces cerevisiae.”
    Biosci. Biotechnol. Biochem.
    Vol.78,1389-1391, 2014
    https://www.ncbi.nlm.nih.gov/pubmed/25130742
  5. Ishiwata-Kimata Y, Yamamoto YH, Takizawa K, Kohno K, Kimata Y
    F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1.
    Cell Struct. Funct. Vol.38, 135-143. 2013
    https://www.ncbi.nlm.nih.gov/pubmed/23666407
  6. Ishiwata-Kimata Y, Promlek T, Kohno K, Kimata Y
    “BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response.”
    Genes Cells Vol.18, 288-301, 2013
    https://www.ncbi.nlm.nih.gov/pubmed/23387983
  7. Nguyen TSL, Kohno K, Kimata Y
    “Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms.”
    Biosci. Biotechnol. Biochem. Vol. 77, 1337-1339, 2013
    https://www.ncbi.nlm.nih.gov/pubmed/23748779
  8. Promlek T, Ishiwata-Kimata Y, Shido M, Sakuramoto M, Kohno K,※Kimata Y
    “Membrane aberrancy and unfolded aroteins activate the endoplasmic reticulum-stress sensor Ire1 by different manners.”
    Mol. Biol. Cell Vol.22, 3520-3532, 2011
    https://www.ncbi.nlm.nih.gov/pubmed/21775630
  9. Yanagitani K, Kimata Y, Kadokura H, Kohno K
    “Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.”
    Science Vol.331, 586-589, 2011
    https://www.ncbi.nlm.nih.gov/pubmed/21233347
  10. Yamamoto YH, Kimura T, Momohara S, Takeuchi M, Tani T, Kimata Y, Kadokura H, Kohno K
    “A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.”
    Cell Struct. Funct. Vol.35, 107-116, 2010
    https://www.ncbi.nlm.nih.gov/pubmed/21150129
  11. Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y, Kohno K
    “Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.”
    Mol. Cell Vol.34, 191-200, 2009
    https://www.ncbi.nlm.nih.gov/pubmed/19394296
  12. Oikawa D, Kimata Y, Kohno K, Iwawaki T
    “Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.”
    Exp. Cell Res. Vol. 315, 2496-2504. 2009
    https://www.ncbi.nlm.nih.gov/pubmed/19538957
  13. Takeuchi M, Kimata Y, Kohno K
    Saccharomyces cerevisiae Rot1 Is an Essential Molecular Chaperone in the Endoplasmic Reticulum.”
    Mol. Biol. Cell Vol.19, 3514-3525, 2008
    https://www.ncbi.nlm.nih.gov/pubmed/18508919
  14. Kimata Y, Ishiwata-Kimata Y, Ito T, Hirata A, Suzuki T, Oikawa D, Takeuchi M, Kohno K
    “Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins.”
    J. Cell Biol. Vol.179, 75-86, 2007
    https://www.ncbi.nlm.nih.gov/pubmed/17923530
  15. Kimura Y, Saito M, Kimata Y, Kohno K
    “Transgenic mice expressing a fully nontoxic diphtheria toxin mutant, not CRM197 mutant, acquire immune tolerance against diphtheria toxin.”
    J. Biochem. Vol.142, 105-112, 2007
    https://www.ncbi.nlm.nih.gov/pubmed/17522091
  16. Oikawa D, Kimata Y, Kohno K
    “Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.”
    J. Cell Sci.
    Vol.120, 1681-1688, 2007
    https://www.ncbi.nlm.nih.gov/pubmed/17452628
  17. Takeuchi M, Kimata Y, Hirata A, Oka M, Kohno K
    Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding.”
    J. Biochem. Vol.139, 597-605, 2006
    https://www.ncbi.nlm.nih.gov/pubmed/16567426
  18. Kimata Y, Ishiwata-Kimata Y, Yamada S, Kohno K
    “Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins.”
    Genes Cells. Vol.11, 59-69, 2006
    https://www.ncbi.nlm.nih.gov/pubmed/16371132
  19. Oikawa D, Kimata Y, Takeuchi M, Kohno K
    “An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1.”
    Biochem J. Vol.391, 135-142, 2005
    https://www.ncbi.nlm.nih.gov/pubmed/15954865
  20. Kimata Y, Oikawa D, Shimizu Y, Ishiwata-Kimata Y, Kohno, K
    “A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.”
    J. Cell Biol. Vol.167, 445-456, 2004
    https://www.ncbi.nlm.nih.gov/pubmed/15520230
  21. Kimata Y, Kimata YI, Shimizu Y, Abe H, Farcasanu IC, Takeuchi M, Rose MD, Kohno K
    “Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.”
    Mol. Biol. Cell Vol.14, 2559-2569, 2003
    https://www.ncbi.nlm.nih.gov/pubmed/12808051
  22. Ohdate H, Lim CR, Kokubo T, Matsubara K, Kimata Y, Kohno K
    “Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth.”
    J. Biol. Chem. Vol.278, 14647-14656, 2003
    https://www.ncbi.nlm.nih.gov/pubmed/12576485
  23. Hosoda A, Kimata Y, Tsuru A, Kohno K
    “JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.”
    J. Biol. Chem. Vol.278, 2669-2676 2003
    https://www.ncbi.nlm.nih.gov/pubmed/12446677
  24. Fujioka Y, Kimata Y, Nomaguchi K, Watanabe K, Kohno K
    “Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5/SMC6 complex involved in DNA repair.”
    J. Biol. Chem. Vol.277, 21585-21591, 2002
    https://www.ncbi.nlm.nih.gov/pubmed/11927594
  25. Okushima Y, Koizumi N, Yamaguchi Y, Kimata Y, Kohno K, Sano H
    Isolation and Characterization of a Putative Transducer of Endoplasmic Reticulum Stress in Oryza sativa.”
    Plant Cell Physiol. Vol.43, 532-539, 2002
    https://www.ncbi.nlm.nih.gov/pubmed/12040100
  26. Koizumi N, Martinez I, Kimata Y, Kohno K, Sano H, Chrispeels MJ
    “Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum located transmembrane protein kinases.”
    Plant Physiol.Vol.127, 949-962, 2001
    https://www.ncbi.nlm.nih.gov/pubmed/11706177
  27. Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, Mekada E, Kimata Y, Tsuru A, Kohno K
    “Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice.”
    Nature Biotechnol.Vol.19, 746-750, 2001
    https://www.ncbi.nlm.nih.gov/pubmed/11479567
  28. Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K
    “Translation control by ER transmembrane kinase/ribonuclease IRE1 under ER stress.”
    Nature Cell Biol.Vol.3, 158-164, 2001
    https://www.ncbi.nlm.nih.gov/pubmed/11175748
  29. Kimata Y, Ooboki K, Nomura-Furuwatari C, Hosoda A, Tsuru A, Kohno K
    “Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search.”
    Gene Vol.261, 321-327, 2000
    https://www.ncbi.nlm.nih.gov/pubmed/11167020
  30. Yoshizawa F, Miura Y, Tsurumaru K, Kimata Y, Yagasaki K, Funabiki R
    “Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation.”
    Biosci. Biotechnol. Biochem. Vol.64, 2482-2485, 2000
    https://www.ncbi.nlm.nih.gov/pubmed/11193422
  31. Okamura K, Kimata Y, Higashio H, Tsuru A, Kohno K
    “Dissociation of Kar2p/BiP from an endoplasmic reticulum sensory molecule, Ire1p, triggers unfolded protein response in yeast.”
    Biochem. Biophys. Res. Commun.Vol.279, 445-450, 2000
    https://www.ncbi.nlm.nih.gov/pubmed/11118306
  32. 32. Lim CR, Kimata Y, Ohdate H, Kokubo T, Kikuchi N, Horigome T, Kohno K
    “The Saccharomyces cerevisiae RuvB-like protein, Tih2p is required for cell cycle progression.”
    J. Biol. Chem.Vol.275, 22409-22417, 2000
    https://www.ncbi.nlm.nih.gov/pubmed/10787406
  33. Higashio H, Kimata Y, Kiriyama T, Hirata A, Kohno K
    “Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum.”
    J. Biol. Chem.Vol.275, 17900-17908, 2000
    https://www.ncbi.nlm.nih.gov/pubmed/10749860
  34. Kimata Y, Higashio H, Kohno K
    “Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP.”
    J. Biol. Chem.Vol.275, 10655-10660, 2000
    https://www.ncbi.nlm.nih.gov/pubmed/10744762
  35. Kimata Y, Lim CR, Kiriyama T, Nara A, Hirata A, Kohno K
    “Mutation of the yeast epsilon-COP gene ANU2 causes abnormal nuclear morphology and defects in intracellular vesicular transport.”
    Cell Struct. Funct.Vol.24, 197-208, 1999
    https://www.ncbi.nlm.nih.gov/pubmed/10532354
  36. Oka M, Nakai M, Endo T, Lim CR, Kimata Y, Kohno K
    “Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae.”
    J. Biol. Chem. Vol.273, 29727-29737, 1998
    https://www.ncbi.nlm.nih.gov/pubmed/9792686
  37. Kimata Y, Iwaki M, Lim CR, Kohno K
    “A novel mutation which enhances the fluorescence of green fluorescent protein at high temperatures.”
    Biochem. Biophys. Res. Commun.Vol.232, 69-73, 1997
    https://www.ncbi.nlm.nih.gov/pubmed/9125154
  38. Oka M, Kimata Y, Mori K, Kohno K
    Saccharomyces cerevisiae KAR2 (BiP) gene expression is induced by loss of cytosolic HSP70/Ssa1p through a heat shock element-mediated pathway.”
    J. Biochem. Vol.121, 578-584, 1997
    https://www.ncbi.nlm.nih.gov/pubmed/9133628
  39. Lim CR, Kimata Y, Oka M, Nomaguchi K, Kohno K
    “Thermosensitivity of green fluorescent protein fluorescence utilized to reveal novel nuclear-like compartments in a mutant nucleoporin NSP1.”
    J. Biochem. Vol.118, 13-17 1995
    https://www.ncbi.nlm.nih.gov/pubmed/8537302
  40. Kimata Y, Kohno K
    “Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth.”
    J. Biol. Chem.Vol.269, 13497-134501 1994
    https://www.ncbi.nlm.nih.gov/pubmed/8175783
  41. Kimata Y, Harashima S, Kohno K
    “Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae.”
    Biochem. Biophys. Res. Commun. Vol.191, 1145-1151 1993
    https://www.ncbi.nlm.nih.gov/pubmed/8466491
  42. Masui M, Tsuchida K, Kimata Y, Ozaki S
    “Epoxidation catalyzed by manganese(III) tetraphenylporphyrin chloride using dioxygen activated by a novel system containing N-hydroxyphthalimide and styrene.”
    Chem. Pharm. Bull. Vol.35, 3078-3081, 1987

Reviews, etc

English

  1. Oikawa D, Kimata Y
    “Experimental approaches for elucidation of stress-sensing mechanisms of the Ire1 family proteins.”
    Methods Enzymol. Vol.490, 195-216, 2011
  2. Kimata Y, Kohno K
    “Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cellsh”
    Curr. Opp. Cell. Biol. Vol.23, 135-142, 2011
    https://www.ncbi.nlm.nih.gov/pubmed/21093243
  3. Takeuchi M, Kimata Y, Kohno K
    “Causal links between protein folding in the ER and events along the secretory pathway.”
    Autophagy Vol.2, 323-324, 2006
    https://www.ncbi.nlm.nih.gov/pubmed/16874095
  4. Kimata Y, Lim CR, Kohno K
    “S147P green fluorescent protein: a less thermosensitive green fluorescent protein variant.”
    Methods Enzymol. Vol.302, 373-378, 1999

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