発表論文
【2024】
(51) Naoya Shigesada, Naoya Shikada, Manabu Shirai, Michinori Toriyama, Fumiaki Higashijima, Kazuhiro Kimura, Toru Kondo, Yasumasa Bessho, Takuma Shinozuka, *Noriaki Sasai.
“Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration”.
Cellular and Molecular Life Sciences (2024) 81: 51.
DOI: 10.1007/s00018-023-05087-x
(50) *Noriaki Sasai, Shogo Tada, Jumi Ohshiro, Chikara Kogiso, Takuma Shinozuka
“Regulation of progenitor cell survival by a novel chromatin remodelling factor during neural tube development”.
Development Growth and Differentiation (2024) 66: 89-100.
DOI: 10.1111/dgd.12905
【2023】
(49) Takuma Shinozuka, Motoko Aoki, Yudai Hatakeyama, Noriaki Sasai, Hitoshi Okamoto, Shinji Takada.
“Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos”.
Developmental Dynamics (2023)
DOI: 10.1002/dvdy.659
(48) Agnes Lee Chen Ong, *Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto, Ayako Isotani, *Manabu Shirai, *Noriaki Sasai.
“Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification”.
iScience (2023) 26: 107887. (erratum 26: 108257)
DOI: 10.1016/j.isci.2023.107887
DOI: 10.1016/j.isci.2023.108257
(47) Haruka Matsukuma, Yuka Kobayashi, Shintaro Oka, Fumiaki Higashijima, Kazuhiro Kimura, Erika Yoshihara, Noriaki Sasai, and Koji Shiraishi.
“Prominin-1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice”.
Reproductive Medicine and Biology (2023) 22: e12514.
DOI: 10.1002/rmb2.12514
(46) Maho Yamamoto, Agnes Ong Lee Chen, Takuma Shinozuka, Manabu Shirai, *Noriaki Sasai.
“Manipulation of signal gradient and transcription factors recapitulates multiple hypothalamic identities”.
STEM CELLS (2023) 41: 453-467.
【2022】
(45) #Maho Yamamoto, #Agnes Ong Lee Chen, Takuma Shinozuka, *Noriaki Sasai.
“The Rx transcription factor is required for determination of the retinal lineage and regulates the timing of neuronal differentiation”.
Development Growth and Differentiation (2022) 64: 318-324.
DOI: 10.1111/dgd.12796
(44) Miki Nishio, Takuya Matsuura, Shunya Hibi, Shiomi Ohta, Chio Oka, Noriaki Sasai, Yasumasa Ishida, Eishou Matsuda.
“Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression”.
Cell Proliferation (2022) e13215.
DOI: 10.1111/cpr.13215
(43) Taiki Katsuyama, Minori Kadoya, Manabu Shirai, *Noriaki Sasai.
“Sox14 is essential for initiation of interneuron differentiation in the chick spinal cord”.
Developmental Dynamics (2022) 251: 350-361.
DOI: 10.1002/dvdy.392
【2021】
(42) #Yuka Kobayashi, Shizuka Watanabe, Agnes Ong Lee Chen, Manabu Shirai, Chiemi Yamashiro, Tadahiko Ogata, Fumiaki Higashijima, Takuya Yoshimoto, Takahide Hayano, Yoshiyuki Asai, #*Noriaki Sasai, Kazuhiro Kimura.
“Early manifestations and differential gene expression associated with photoreceptor degeneration in Prominin-1-deficient retina.”
Disease Models and Mechanisms (2021) 14: dmm048962.
DOI: 10.1242/dmm.048962
【2020】
(41) Vasiliki Papadaki, Ken Asada, Julie K. Watson, Toshiya Tamura, Alex Leung, Jack Hopkins, Margaret Dellett, Noriaki Sasai, Hongorzul Davaapil, Serena Nik-Zainal, Rebecca Longbottom, Makoto Nakakido, Ryo Torii, Abhi Veerakumarasivam, Syuzo Kaneko, Mandeep S. Sagoo, Gillian Murphy, Akihisa Mitani, Kohei Tsumoto, John D. Kelly, Ryuji Hamamoto, Shin-ichi Ohnuma.
“Two secreted proteoglycans, activators of urothelial cell–cell adhesion, negatively contribute to bladder cancer initiation and progression.”
Cancers (2020) 12: 3362.
(40) Kamila Alawiyah, Berry Juliandi, Arief Boediono, Noriaki Sasai.
“Oral Administration of Incense Resin (Styrax benzoin) Extract enhances spatial learning, memory, and dendrite complexity of mice.”
Brazilian Archives of Biology and Technology (2020) 63: e20180379.
DOI: 10.1590/1678-4324-2020180379
(39) *Noriaki Sasai, Minori Kadoya, Agnes Ong Lee Chen
“Neural induction: Historical views and application to pluripotent stem cells.”
Development Growth and Differentiation (2020) 63:26-37.
DOI: 10.1111/dgd.12703
・脳科学辞典
「脳の領域化」(2020) https://bsd.neuroinf.jp/wiki/脳の領域化
「コーディン」(2020) https://bsd.neuroinf.jp/wiki/コーディン
【2019】
(38) *Noriaki Sasai, Michinori Toriyama, Toru Kondo
“Hedgehog signal and genetic disorders”
Frontiers in Genetics (2019) 10: 1103
(37) Akiko Hori, Kenji Nishide, Yuki Yasukuni, Kei Haga, Wataru Kakuta, Yasuyuki Ishikawa, Matthew J Hayes, Shin-ichi Ohnuma, Hiroshi Kiyonari, Kazuhiro Kimura, Toru Kondo, *Noriaki Sasai.
“Prominin-1 modulates Rho/ROCK-mediated membrane morphology and calcium-dependent intracellular chloride flux.”
Scientific Reports (2019) 9: 15911.
DOI: 10.1038/s41598-019-52040-9
(36) Minori Kadoya, *Noriaki Sasai.
“Negative regulation of mTOR signalling restricts cell proliferation in the floor plate.”
Frontiers in Neuroscience (2019) 13: 1022.
(35) Atsuki Yatsuzuka, Akiko Hori, Minori Kadoya, Mami Matsuo-Takasaki, Toru Kondo, *Noriaki Sasai.
“GPR17 is an essential regulator for the temporal adaptation of Sonic Hedgehog signalling in neural tube development.”
Development (2019) 146: dev176784.
DOI: 10.1242/dev.176784
【2018】
(34) Barbara Vacca, Elena Sanchez-Heras, Emily Steed, Maria Balda, Shin-ichi Ohnuma, Noriaki Sasai, Roberto Mayor, Karl Matter
"Control of neural crest induction by MarvelD3-mediated attenuation of JNK signaling."
Scientific Reports (2018) 8: 1204.
DOI: 10.1038/s41598-018-19579-5
・脳科学辞典
「位置情報」(2018) https://bsd.neuroinf.jp/wiki/位置情報
【2017】
・脳科学辞典
「神経誘導」(2017) https://bsd.neuroinf.jp/wiki/神経誘導
「ソニック・ヘッジホッグ」(2017) http://bsd.neuroinf.jp/wiki/ソニック・ヘッジホッグ
【2016】
(33) Barbara Vacca, Elena Sanchez-Heras, Emily Steed, Maria S. Balda, Shin-ichi Ohnuma, Noriaki Sasai, Roberto Mayor, Karl Matters
“MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.”
Biology Open (2016) 5: 1631-1641.
DOI: 10.1242/bio.018945
(32) Eva Kutejova, Noriaki Sasai, Ankita Shah, Mina Gouti, James Briscoe
“Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs.”
Developmental Cell (2016) 36: 639-653.
DOI: 10.1016/j.devcel.2016.02.013
(31) Alice E. Davidson, Petra Liskova, Cerys J. Evans, Lubica Dudakova, Lenka Nosková, Nikolas Pontikos, Hana Hartmannová, Kateřina Hodaňová, Viktor Stránecký, Zbyněk Kozmík, Hannah J. Levis, Nwamaka Idigo, Noriaki Sasai, Geoffrey J. Maher, James Bellingham, Neyme Veli, Neil D. Ebenezer, Michael E. Cheetham, Julie T. Daniels, Caroline M.H. Thaung, Katerina Jirsova, Vincent Plagnol, Martin Filipec, Stanislav Kmoch, Stephen J. Tuft, Alison J. Hardcastle
“Autosomal-dominant corneal endothelial dystrophies CHED1 and PPCD1 are allelic disorders caused by non-coding mutations in the promoter of OVOL2.”
The American Journal of Human Genetics (2016) 98: 75-89.
DOI: 10.1016/j.ajhg.2015.11.018
【2015】
(30) Kristin Luehders, Noriaki Sasai (KL and NS are equal contributors), Hongorzul Davaapil, Maiko Kurosawa-Yoshida, Hitoshi Hiura, Tara Brah, Shin-ichi Ohnuma
“The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.”
Development (2015) 142: 3351-3361.
DOI: 10.1242/dev.124438
(29) #Margaret Dellett, #Noriaki Sasai, Kenji Nishide, Silke Becker, Vasiliki Papadaki, G. Astrid Limb, Anthony T. Moore, Toru Kondo, Shin-ichi Ohnuma
“Genetic background and light dependent progression of photoreceptor cell degeneration in Prominin1 knockout mice.”
Investigative Ophthalmology and Visual Science (2015) 56: 164-176.
【before 2015】
(28) Noriaki Sasai, Eva Kutejova, James Briscoe
“Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity.”
PLOS Biology (2014) 12: e1001907.
DOI: 10.1371/journal.pbio.1001907
(27) John Jacob, Vanessa Ribes, Steven Moore, Sean C. Constable, Noriaki Sasai, Sebastian S. Gerety, Darren J. Martin, Chris P. Sergeant, David G. Wilkinson, James Briscoe
“Valproic Acid silencing of ascl1b/ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.”
Disease Models and Mechanisms (2014) 7: 107-117.
DOI: 10.1242/dmm.013219
(26) Sebastian S. Gerety, Marie A. Breau, Noriaki Sasai, Qiling Xu, James Briscoe, David G. Wilkinson
“An inducible transgene expression system for zebrafish and chick.”
Development (2013) 140: 2235-2243.
DOI: 10.1242/dev.091520
(25) John Jacob, Jennifer Kong, Steven Moore, Christopher Milton, Noriaki Sasai, Rosa Gonzalez-Quevedo, Javier Terriente, Itaru Imayoshi, Ryoichiro Kageyama, David G. Wilkinson, Bennett G. Novitch, James Briscoe
“Retinoid acid specifies neuronal identity through graded expression of Ascl1.”
Current Biology (2013) 23: 412–418.
DOI: 10.1016/j.cub.2013.01.046
(24) Nikolaos Balaskas, Ana Ribeiro, Jasmina Panovska, Eric Dessaud, Noriaki Sasai, Karen M. Page, James Briscoe, Vanessa Ribes
“Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.”
Cell (2012) 148: 273-284.
DOI: 10.1016/j.cell.2011.10.047
(23) Noriaki Sasai, James Briscoe
“Primary cilia and graded Sonic Hedgehog signaling”
Interdisciplinary Reviews of Developmental Biology (WIREs Developmental Biology) (2012)
DOI: 10.1002/wdev.43
(22) Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe, Jin Jiang
“Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of Smoothened.”
PLOS Biology (2011) 9: e1001083.
DOI: 10.1371/journal.pbio.1001083
(21) Daisuke Kamiya, Satoe Banno, Noriaki Sasai, Masatoshi Ohgushi, Hidehiko Inomata, Kiichi Watanabe, Masako Kawada, Rieko Yakura, Hiroshi Kiyonari, Kazuki Nakao, Lars Martin Jakt, Shin-ichi Nishikawa, Yoshiki Sasai
“Intrinsic transition of embryonic-stem cell differentiation into neural progenitors.”
Nature (2011) 470: 503-509.
DOI: 10.1038/nature09726
(20) Toshihiro Aramaki, Noriaki Sasai, Rieko Yakura, Yoshiki Sasai
“Jiraiya attenuates BMP signaling by interfering with Type-II BMP receptors in neuroectodermal patterning.”
Developmental Cell (2010) 19: 547-561.
DOI: 10.1016/j.devcel.2010.09.001
(19) #Eric Dessaud, Vanessa Ribes, Nikolaos Balaskas, Lin Lin Yang, Alessandra Pierani, Anna Kicheva, Bennett G. Novitch, James Briscoe, #Noriaki Sasai.
“Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen Sonic Hedgehog.”
PLOS Biology (2010) 8: e1000382.
DOI: 10.1371/journal.pbio.1000382
(18) #Vanessa Ribes, #Nikolaos Balaskas, #Noriaki Sasai, Catarina Cruz, Eric Dessaud, Jordi Cayuso, Samuel Tozer, Lin Lin Yang, Bennett G. Novitch, Elisa Marti, James Briscoe
“Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.”
Genes and Development (2010) 24: 1186-1200.
DOI: 10.1101/gad.559910
・ 「とにかくよく議論する人々（ラボレポート留学編）」
実験医学（羊土社）2010年6月号
(17) Nagatoshi Kinoshita, Noriaki Sasai, Kazuyo Misaki, Shigenobu Yonemura
“Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation.”
Molecular Biology of the Cell (2008) 19: 2289-2299.
(16) *Noriaki Sasai, Rieko Yakura, Daisuke Kamiya, Yoko Nakazawa, *Yoshiki Sasai.
“Ectodermal factor restricts mesoderm differentiation by inhibiting p53.”
Cell (2008) 133: 878-890.
DOI: 10.1016/j.cell.2008.03.035
・ 「外胚葉因子がp53の活性を阻害することにより中胚葉分化を抑制する」
実験医学（羊土社）2008年10月号
(15) Takayuki Onai, Mami Matsuo-Takasaki, Hidehiko Inomata, Toshihiro Aramaki, Michiru Matsumura, Rieko Yakura, Noriaki Sasai, Yoshiki Sasai
“XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination.”
EMBO Journal (2007) 26: 2350-2360.
(14) Akiko Arakawa, Mami Matsuo-Takasaki, Akira Takai, Hidehiko Inomata, Michiru Matsumura, Makoto Ikeya, Kenzo Takahashi, Yoshiki Miyachi, Noriaki Sasai, Yoshiki Sasai
“The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo.”
Developmental Biology (2007) 306: 160-169.
DOI: 10.1016/j.ydbio.2007.03.008
(13) Makoto Ikeya, Masako Kawada, Hiroshi Kiyonari, Noriaki Sasai, Kazuki Nakao, Yasuhide Furuta, Yoshiki Sasai
“Essential Pro-BMP roles of Crossveinless 2 in mouse organogenesis.”
Development (2006) 133: 4463-4473.
DOI: 10.1242/dev.02647
(12) Makoto Sakuragi, Noriaki Sasai, Makoto Ikeya, Masako Kawada, Takayuki Onai, Tatsuya Katahira, Harukazu Nakamura, Yoshiki Sasai
“Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors.”
Mechanisms of Development (2006) 123: 114-123.
DOI: 10.1016/j.mod.2005.11.005
(11) Hanako Ikeda, Fumitaka Osakada, Kiichi Watanabe, Kenji Mizuseki, Tomoko Haraguchi, Hiroyuki Miyoshi, Daisuke Kamiya, Yoshihito Honda, Noriaki Sasai, Nagahisa Yoshimura, Masayo Takahashi, Yoshiki Sasai
“Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells.”
Proceedings of the National Academy of Sciences of the United States of America (PNAS) (2005) 102: 11331-11336.
(10) Makoto Ikeya, Masako Kawada, Yoko Nakazawa, Makoto Sakuragi, Noriaki Sasai, Morio Ueno, Hiroshi Kiyonari, Kazuki Nakao, Yoshiki Sasai
“Gene disruption/knock-in analysis of mONT3: Vector construction by combining in vivo and in vitro recombinations.”
The International Journal of Developmental Biology (2005) 49: 807-823.
(9) Takahiko Sato, Noriaki Sasai, Yoshiki Sasai
“Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm.”
Development (2005) 132: 2855-2863.
DOI: 10.1242/dev.01823
(8) Noriaki Sasai, Yoko Nakazawa, Tomoko Haraguchi, Yoshiki Sasai
“The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements.”
Nature Cell Biology (2004) 6: 741-748.
DOI: 10.1038/ncb1158
(7) Takayuki Onai, Noriaki Sasai, Masaru Matsui, Yoshiki Sasai
“Xenopus XsalF; anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt Signaling.”
Developmental Cell (2004) 7: 95-106.
DOI: 10.1016/j.devcel.2004.06.004
(6) Hiroshi Tsuda, Noriaki Sasai, Mami Matsuo-Takasaki, Makoto Sakuragi, Yoshinori Murakami, Yoshiki Sasai
"Dorsalization of the neural tube by Xenopus Tiarin, a novel patterning factor secreted by the flanking nonneural head ectoderm."
Neuron (2002) 33: 515-528.
DOI: 10.1016/s0896-6273(02)00590-1
・ 「未分化外胚葉の分化決定機構」
「脳・神経研究のフロンティア（実験医学、増刊号）」（羊土社）2002年3月
(5) Noriaki Sasai, Kenji Mizuseki, Yoshiki Sasai
"Requirement of FoxD3-class signaling for neural crest determination in Xenopus."
Development (2001) 128: 2525-2536.
(4) Masashi Kishi, Kenji Mizuseki, Noriaki Sasai, Hiroshi Yamazaki, Kohei Shiota, Shigetada Nakanishi, Yoshiki Sasai
"Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm."
Development (2000) 127: 791-800.
(3) Yoshinori Kawazoe, Masako Tanabe, Noriaki Sasai, Kazuhiro Nagata, Akira Nakai
"HSF3 is a major heat shock response factor during chicken embryonic development."
European Journal of Biochemistry (1999) 265: 688-697.
DOI: 10.1046/j.1432-1327.1999.00762.x
(2) #Masako Tanabe, #Noriaki Sasai, Kazuhiro Nagata, Xiao-Dong Liu, Phillip C. C. Liu, Dennis J. Thiele, Akira Nakai
"The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing."
Journal of Biological Chemistry (1999) 274: 27845-27856.
(1) Hirofumi Komori, Noriaki Sasai, Fujihiko Matsunaga, Chieko Wada, Kunio Miki
"Crystallization and preliminary X-ray diffraction studies of a replication initiator protein (RepE54) of the Mini-F plasmid complexed with iteron DNA."
Journal of Biochemistry (Tokyo) (1999) 125: 24-26.