One of the central questions of classical developmental biology is to understand how a limited number of genes produce a diversity of cell types. The developing central nervous system is composed of a number of different cell types, and we seek to elucidate molecular mechanisms leading to this diversity by employing chick and mouse embryos as model organisms.
We are also interested in the homeostasis of functional neurons. We have been utilising the model mice that have been shown to develop particular inherited retinal diseases. Our recent study has revealed that these animals also harbour many other dystrophies. By analysing the detailed molecular mechanisms, we attempt to propose novel therapeutics for these related dystrophies.
Overall, our research program aims to be influential in cell and developmental biology and will furthermore be scientifically and technically cross-disciplinary across basic biology and clinical biomedical sciences.