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![FEN1とPCNAの複合体の結晶構造](/hako/images/fen1-pcna.gif)
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![Radixin FERMドメインとICAM-2ペプチドとの複合体の結晶構造](/hako/images/radixin_icam.gif)
![Rho-kinaseのRhoA結合ドメインの結晶構造](/hako/images/rho_binding.gif)
Shimizu T. et al., and Hakoshima T.
Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
J Biol Chem. 2003 Nov 14;278(46):46046-51.
[ Journal / PubMed / PDB ]
Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
J Biol Chem. 2003 Nov 14;278(46):46046-51.
[ Journal / PubMed / PDB ]
![GTPCH I と GFRP との高活性型複合体の結晶構造](/hako/images/gtpchi_gfrp_act2.gif)
![Merlinの FERM ドメインの結晶構造](/hako/images/merlin.gif)
Shimizu T. et al., and Hakoshima T.
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.
J Biol Chem. 2002 Mar 22;277(12):10332-6.
[ Journal / PubMed / PDB ]
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.
J Biol Chem. 2002 Mar 22;277(12):10332-6.
[ Journal / PubMed / PDB ]
![Radixin FERM ドメインの結晶構造](/hako/images/radixin.gif)
![Radixin FERM ドメインとIP3 との複合体の結晶構造](/hako/images/radixin_ip3.gif)
![Mg2+イオン非結合状態のGDP結合型RhoAの結晶構造](/hako/images/rhoa_mg_free.gif)
![転写因子Pap1とDNAとの複合体の結晶構造](/hako/images/pap.gif)
Fujii Y. et al., and Hakoshima T.
Structural basis for the diversity of DNA recognition by bZIP transcription factors.
Nat Struct Biol. 2000 Oct;7(10):889-93.
[ Journal / PubMed / PDB ]
Structural basis for the diversity of DNA recognition by bZIP transcription factors.
Nat Struct Biol. 2000 Oct;7(10):889-93.
[ Journal / PubMed / PDB ]
![](/hako/images/arcb_hpt_ch.gif)
![](/hako/images/rhoa_pkn.gif)
![](/hako/images/irf2.gif)
![](/hako/images/hbp23.gif)
![](/hako/images/neuropsin.gif)
Kishi T. et al., and Hakoshima T.
Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis.
J Biol Chem. 1999 Feb 12;274(7):4220-4.
[ Journal / PubMed / PDB ]
Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis.
J Biol Chem. 1999 Feb 12;274(7):4220-4.
[ Journal / PubMed / PDB ]
![](/hako/images/rhoa.gif)
ヒト由来低分子量G蛋白質RhoAのGTPγS結合型(活性型)結晶構造を決定し,Rhoファミリーに特徴的な13残基の挿入部位はスイッチ機構に関与していないことを示すとともに,GTP-GDP交換によるRhoAのスイッチ機構を解明した。
Ihara K. et al., and Hakoshima T.
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
J Biol Chem. 1998 Apr 17;273(16):9656-66.
[ Journal / PubMed / PDB ]