Sakurai S. et al., and Hakoshima T.
Structural basis for recruitment of human flap endonuclease 1 to PCNA
EMBO J. 2005 Feb 23;24(4):683-93.
[ Journal / PubMed / PDB ]

Maita N. et al., and Hakoshima T.
Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein.
J Biol Chem. 2004 Dec 3;279(49):51534-40. 
[ Journal / PubMed / PDB ]

Hamada K. et al., and Hakoshima T.
Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex.
EMBO J 2003 Feb 3;22(3):502-514
[ Journal / PubMed / PDB ]

Shimizu T. et al., and Hakoshima T.
Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
J Biol Chem. 2003 Nov 14;278(46):46046-51.
[ Journal / PubMed / PDB ]

 

Maita N. et al., and Hakoshima T.
Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1212-7.
[ Journal / PubMed / PDB(1IS7,1IS8) ]

Shimizu T. et al., and Hakoshima T.
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.
J Biol Chem. 2002 Mar 22;277(12):10332-6.
[ Journal / PubMed / PDB ]

 

Hamada K. et al., and Hakoshima T.
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J. 2000 Sep 1;19(17):4449-62.
[ Journal / PubMed / PDB ]

Shimizu T. et al., and Hakoshima T.
An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.
J Biol Chem. 2000 Jun 16;275(24):18311-7.
[ Journal / PubMed / PDB ]

Fujii Y. et al., and Hakoshima T.
Structural basis for the diversity of DNA recognition by bZIP transcription factors.
Nat Struct Biol. 2000 Oct;7(10):889-93.
[ Journal / PubMed / PDB ]

 

Kato M. et al., and Hakoshima T.
Structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor protein ArcB complexed with the chemotaxis response regulator CheY.
Acta Crystallogr D Biol Crystallogr. 1999 Jul;55 ( Pt 7):1257-63.
[ Journal / PubMed / PDB ]

Maesaki R. et al., and Hakoshima T.
The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Mol Cell. 1999 Nov;4(5):793-803.
[ Journal / PubMed / PDB ]

Fujii Y. et al., and Hakoshima T.
Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
EMBO J. 1999 Sep 15;18(18):5028-41.
[ Journal / PubMed / PDB ]

Hirotsu S. et al., and Hakoshima T.
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12333-8.
[ Journal / PubMed / PDB ] 

Kishi T. et al., and Hakoshima T.
Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis.
J Biol Chem. 1999 Feb 12;274(7):4220-4.
[ Journal / PubMed / PDB ]

 

ヒト由来低分子量G蛋白質RhoAのGTPγS結合型（活性型）結晶構造を決定し，Rhoファミリーに特徴的な１３残基の挿入部位はスイッチ機構に関与していないことを示すとともに，GTP-GDP交換によるRhoAのスイッチ機構を解明した。

Ihara K. et al., and Hakoshima T.
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
J Biol Chem. 1998 Apr 17;273(16):9656-66.
[ Journal / PubMed / PDB ]

Kato M. et al., and Hakoshima T.
Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB.
Cell. 1997 Mar 7;88(5):717-23.
[ Journal / PubMed / PDB ]

 

Shimizu T. et al., and Hakoshima
Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition.
EMBO J. 1997 Aug 1;16(15):4689-97.
[ Journal / PubMed / PDB ]