メンバー -Member-

渡邉 むつみ (Mutsumi Watanabe, PhD.)

渡邉 むつみ（ワタナベ ムツミ）博士（薬学）

Mutsumi Watanabe, phD

Eメール：mutsumi(at)bs.naist.jp

 

Publication List (論文) 

  1. Tantisuwanichkul K., Komaki S., Watanabe M., Tohge T., Sirikantaramas S. (2024) Unveiling the regulatory role of DzAGL6-1 in carotenoid biosynthesis during durian (Durio zibethinus) fruit development. Plant Cell Reports, 43, 217. 
  2. Jing Y, Watanabe M., Aarabi F, Fernie AR, Borghi M, Tohge T. (2023) Cross-species metabolomic analyses in the brassicaceae reveals common responses to ultraviolet-B exposure. Plant Cell Physiology, 64, 1523-1533.
  3. Aghajanzadeh TA., Watanabe M., Tohge T., Hawkesford MJ., Fernie AR., Hoefgen R., Elzenga JTM., De Kok LJ. (2023) Necrotrophic fungal infection affects indolic glucosinolate metabolism in Brassica rapa. Acta Physiologiae Plantarum, 45, Article number: 64
  4. Buelbuel S., Sakuraba Y., Sedaghatmehr M., Watanabe M., Hoefgen R., Balazadeh S., Mueller-Roeber B. (2023) Arabidopsis BBX14 negatively regulates nitrogen starvation- and dark-induced leaf senescence. The Plant Journal, 116, 251-268.
  5. Watanabe M., Tohge T. (2023) Species-specific “specialized” genomic region provides the new insights into the functional genomics characterizing metabolic polymorphisms in plant. Current Opinion in Plant Biology, 75, 102427.
  6. Aarabi F., Rakpenthai A., Barahimipour R., Gorka M., Alseekh S., Zhang Y., Salem MA., Brückner F., Omranian N., Watanabe M., Nikoloski Z., Giavalisco P., Tohge T., Graf A., Fernie AR., Hoefgen R. (2021) Sulfur deficiency-induced genes affect seed protein accumulation and composition under sulfate deprivation. Plant Physiology, kiab386.
  7. Sangpong L., Khaksar G., Pinsorn P., Oikawa A., Sasaki R., Erban A., Watanabe M., Wangpaiboon K., Tohge T., Kopka J., Hoefgen R., Saito K., Sirikantaramas S. (2021) Assessing Dynamic Changes of Taste-Related Primary Metabolism During Ripening of Durian Pulp Using Metabolomic and Transcriptomic Analyses. Frontiers in Plant Science, 12, 687799. 
  8. Watanabe M., Chiba Y., Hirai MY. (2021) Metabolism and Regulatory Functions of O-Acetylserine, S-Adenosylmethionine, Homocysteine, and Serine in Plant Development and Environmental Responses. Frontiers in Plant Science, 12, 643403. 
  9. Liu Y., Watanabe M., Yasukawa S., Kawamura Y., Aneklaphakij C., Fernie AR., Tohge T.* (2021) Cross-species metabolic profiling of floral specialized metabolism facilitates understanding of evolutional aspects of metabolism among Brassicaceae species. Frontiers in Plant Science, 12, 640141. 
  10. Aneklaphakij C., Saigo T., Watanabe M., Naake T., Fernie AR., Bunsupa S., Satitpatipan V., Tohge T. (2021) Diversity of chemical structures and biosynthesis of polyphenols in nut bearing species. Frontiers in Plant Science, 12, 642581. 
  11. Olas JJ., Apelt F., Watanabe M., Hoefgen R., Wahl V. (2021) Developmental stage-specific metabolite signatures in Arabidopsis thaliana under optimal and mild nitrogen limitation. Plant Science, 303, 110746. 
  12. Calumpang CLF., Saigo T., Watanabe M., Tohge T. (2020) Cross-species comparison of fruit-metabolomics to elucidate metabolic regulation of fruit polyphenolics in pepper (Capsicum annuum cv.) cultivars. Metabolites, 10, 209.
  13. Watanabe M., Ueda Y., Kondo K., Ishikawa S., Tohge T., Burgos A., Brotman Y., Fernie AR., Walther D., Hoefgen R., Wissuwa M. (2020) Metabolomic markers and physiological adaptations for high phosphate utilization efficiency in rice. Plant, Cell & Environment, 43, 2066–2079. 
  14. Tohge T., Scossa F., Wendenburg R., Frasse P., Balbo I., Watanabe M., Alseekh S., Jadhav SS., Delfin JC., Lohse M., Giavalisco P., Usadel B., Zhang Y., Luo J., Bouzayen M., Fernie AR. (2020) Exploiting the natural variation in tomato to define pathway structure and metabolic regulation of fruit polyphenolics in the lycopersicum complex. Molecular Plant, 13, 1027-1046.
  15. Fichtner F., Olas JJ., Feil R., Watanabe M., Krause U., Hoefgen R., Stitt M., Lunn JE. (2020) Functional features of TREHALOSE-6-PHOSPHATE SYNTHASE1 - an essential enzyme in Arabidopsis thaliana. The Plant Cell, 32, 1949–1972.
  16. Saigo T., Tong W., Watanabe M., Tohge T. (2020) Diversity of anthocyanin and proanthocyanin biosynthesis in land plants. Current Opinion in Plant Biology, 55, 93-99.
  17. Hayashi S., Watanabe M., Kobayashi M., Tohge T., Hashimoto T., Shoji T. (2020) Genetic manipulation of transcriptional regulators alters nicotine biosynthesis in tobacco. Plant Cell Physiology, 61, 1041–1053.
  18. Correa Galvis V., Strand DD., Messer M., Thiele W., Bethmann S., Hübner D., Uflewski M., Kaiser E., Siemiatkowska B., Morris BA., Toth SZ., Watanabe M., Brückner F., Hoefgen R., Jahns P., Schöttler MA., Armbruster U. (2020) H+ transport by K+ EXCHANGE ANTIPORTER3 promotes photosynthesis and growth in chloroplast ATP synthase mutants. Plant Physiology, 182, 2126-2142.
  19. Watanabe M., Hoefgen R. (2019) Sulphur systems biology-making sense of omics data. Journal of Experimental Botany, 70, 4155-4170.
  20. Beshir WF., Tohge T., Watanabe M., Hertog MLATM., Fernie AR., Nicolaï BM. (2019) Non-aqueous fractionation revealed changing subcellular metabolite distribution during apple fruit development. Horticulture Research, 6, 98.
  21. Heyneke E., Watanabe M., Erban A., Duan G., Buchner P., Walther D., Kopka J., Hawkesford MJ., Hoefgen R. (2019) Effect of senescence phenotypes and nitrate availability on wheat leaf metabolome during grain filling. Agronomy, 9, 305.
  22. Riedel S., Siemiatkowska B., Watanabe M., Müller CS., Schünemann V., Hoefgen R., Leimkühler S. (2019) The ABCB7-like transporter PexA in Rhodobacter capsulatus is involved in the translocation of reactive sulfur species. Frontiers in Microbiology, 10, 406.
  23. Casartelli A., Melino VJ., Baumann U., Riboni M., Suchecki R., Jayasinghe NS., Mendis H., Watanabe M., Erban A., Zuther E., Hoefgen R., Roessner U., Okamoto M., Heuer S. (2019) Opposite fates of the purine metabolite allantoin under water and nitrogen limitations in bread wheat. Plant molecular biology, 99, 477-497.
  24. Matz JM., Watanabe M., Falade M., Tohge T., Hoefgen R., Matuschewski K. (2019) Plasmodium para-aminobenzoate synthesis and salvage resolve avoidance of folate competition and adaptation to host diet. Cell Reports, 26, 356-363.
  25. Delfin JC., Watanabe M., Tohge T. (2019) Understanding the function and regulation of plant secondary metabolism through metabolomics approaches. Theoretical and Experimental Plant Physiology, 31, 127-138.
  26. Naumann M., Hubberten HM., Watanabe M., Hänsch R., Schöttler MA., Hoefgen R. (2018) Sulfite reductase co-suppression in tobacco reveals detoxification mechanisms and downstream responses comparable to sulfate starvation.  Frontiers in Plant Science, 9, 1423.
  27. Watanabe M., Netzer F., Tohge T., Orf I., Brotman Y., Dubbert D., Fernie AR., Rennenberg H., Hoefgen R., Herschbach C. (2018) Metabolome and lipidome profiles of populus × canescens twig tissues during annual growth show phospholipid-linked storage and mobilization of C, N, and S. Frontiers in Plant Science, 9, 1292.
  28. Pinsorn P., Oikawa A., Watanabe M., Sasaki R., Ngamchuachit P., Hoefgen R, Saito K., Sirikantaramas S. (2018) Metabolic variation in the pulps of two durian cultivars: unraveling the metabolites that contribute to the flavor. Food Chemistry, 268, 118-125.
  29. Watanabe M.*, Tohge T., Fernie AR., Hoefgen R.* (2018) The effect of single and multiple SERAT mutants on serine and sulfur metabolism. Frontiers in Plant Science, 9, 702. *corresponding author.
  30. Shimizu T., Watanabe M., Fernie AR., Tohge T. (2018) Targeted LC-MS analysis for plant secondary metabolites. Methods in Molecular Biology, 1778, 171-181.
  31. Salem MA., Li Y., Bajdzienko K., Fisahn J., Watanabe M., Hoefgen R., Schoettler MA., Giavalisco P. (2018) RAPTOR controls developmental growth transitions by altering the hormonal and metabolic balance. Plant Physiology, 177, 565-593.
  32. Watanabe M., Tohge T., Balazadeh S., Erban A., Giavalisco P., Kopka J., Mueller-Roeber B., Fernie AR., Hoefgen R. (2018) Comprehensive metabolomics studies of plant developmental senescence. Methods in Molecular Biology, 1744, 339-358.
  33. Heyneke E., Watanabe M., Erban A., Duan G., Buchner P., Walther D., Kopka J., Hawkesford MJ., Hoefgen R. (2017) Characterization of the wheat leaf metabolome during grain filling and under varied N-supply. Frontiers in Plant Science, 8, 2048. 
  34. Dong Y., Silbermann M., Speiser A., Forieri I., Linster E., Poschet G., Allboje Samami A., Watanabe M., Sticht C., Teleman AA., Deragon JM., Saito K., Hell R., Wirtz M. (2017) Sulfur availability regulates plant growth via glucose-TOR signaling. Nature Communications, 7, 1174.
  35. Fichtner F., Barbier FF., Feil R., Watanabe M., Annunziata MG., Chabikwa TG., Höfgen R., Stitt M., Beveridge CA., Lunn JE. (2017) Trehalose 6-phosphate is involved in triggering axillary bud outgrowth in garden pea (Pisum sativum L.). The Plant Journal, 92, 611-623.
  36. Ishiga Y., Watanabe M., Ishiga T., Tohge T., Matsuura T., Ikeda Y., Hofgen R., Fernie AR., Mysore KS. (2017) The SAL-PAP chloroplast retrograde pathway contributes to plant immunity by regulating glucosinolate pathway and phytohormone signaling. Molecular Plant-Microbe Interactions, 30, 829-841.
  37. Moschen S., Di Rienzo JA., Higgins J., Tohge T., Watanabe M., González S., Rivarola M., García-García F., Dopazo J., Hopp HE., Hoefgen R., Fernie AR., Paniego N., Fernández P., Heinz RA. (2017) Integration of transcriptomic and metabolic data reveals hub transcription factors involved in drought stress response in sunflower (Helianthus annuus L.). Plant Molecular Biology, 94, 549-564.
  38. Prodhan MA., Jost R., Watanabe M., Hoefgen R., Lambers H., Finnegan PM. (2017) Tight control of sulfur assimilation: an adaptive mechanism for a plant from a severely phosphorus-impoverished habitat. New Phytologist, 215, 1068-1079.
  39. Ploetner B., Nurmi M., Fischer A., Watanabe M., Schneeberger K., Holm S., Vaid N., Schoettler MA., Walther D., Hoefgen R., Weigel D., Laitinen RA. (2017) Chlorosis caused by two recessively interacting genes reveals a role of RNA helicase in hybrid breakdown in Arabidopsis thaliana. The Plant Journal, 91, 251-262.
  40. Prodhan MA., Jost R., Watanabe M., Hoefgen R., Lambers H., Finnegan PM. (2016) Tight control of nitrate acquisition in a plant species that evolved in an extremely phosphorus-impoverished environment. Plant Cell and Environment, 39, 2754-2761.
  41. Aarabi F., Kusajima M., Tohge T., Konishi T., Gigolashvili T., Takamune M., Sasazaki Y., Watanabe M., Nakashita H., Fernie AR., Saito K., Takahashi H., Hubberten HM., Hoefgen R., Maruyama-Nakashita A. (2016) Sulfur deficiency-induced repressor proteins optimize glucosinolate biosynthesis in plants. Science Advances, 2, e1601087.
  42. Vicente R., Perez P., Martinez-Carrasco R., Feil R., Lunn JE., Watanabe M., Arrivault S., Stitt M., Hoefgen R., Morcuende R. (2016) Metabolic and transcriptional analysis of durum wheat responses to elevated CO2 at low and high nitrate supply. Plant and Cell Physiology, 57, 2133-2146.
  43. Tohge T., Wendenburg R., Ishihara H., Nakabayashi R., Watanabe M., Sulpice R., Hoefgen R., Takayama H., Saito K., Stitt M., Fernie AR. (2016) Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae. Nature Communications, 7, 12399.
  44. Figueroa CM., Feil R., Ishihara H., Watanabe M., Kolling K., Krause U., Hoehne M., Encke B., Plaxton WC., Zeeman SC., Li Z., Schulze WX., Hoefgen R., Stitt M., Lunn JE. (2016) Trehalose 6-phosphate coordinates organic and amino acid metabolism with carbon availability. The Plant Journal, 85, 410-423.
  45. Moschen S., Bengoa Luoni S., Di Rienzo JA., Caro Mdel P., Tohge T., Watanabe M., Hollmann J., Gonzalez S., Rivarola M., Garcia-Garcia F., Dopazo J., Hopp HE., Hoefgen R., Fernie AR., Paniego N., Fernandez P., Heinz RA. (2016) Integrating transcriptomic and metabolomic analysis to understand natural leaf senescence in sunflower. Plant Biotechnology Journal, 14, 719-734.
  46. Zuchi S., Watanabe M., Hubberten HM., Bromke M., Osorio S., Fernie AR., Celletti S., Paolacci AR., Catarcione G., Ciaffi M., Hoefgen R., Astolfi S. (2015) The interplay between sulfur and iron nutrition in tomato. Plant Physiology, 169, 2624-2639.
  47. Speiser A., Haberland S., Watanabe M., Wirtz M., Dietz KJ., Saito K., Hell R. (2015) The significance of cysteine synthesis for acclimation to high light conditions. Frontiers in Plant Science, 5, 776.
  48. Bielecka M., Watanabe M., Morcuende R., Scheible WR., Hawkesford MJ., Hesse H., Hoefgen R. (2015) Transcriptome and metabolome analysis of plant sulfate starvation and resupply provides novel information on transcriptional regulation of metabolism associated with sulfur, nitrogen and phosphorus nutritional responses in Arabidopsis. Frontiers in Plant Science, 5, 805.
  49. Weissgerber T.+, Watanabe M.+, Hoefgen R., Dahl C. (2014) Metabolomic profiling of the purple sulfur bacterium Allochromatium vinosum during growth on different reduced sulfur compounds and malate. Metabolomics, 10, 1094-1112. +equal first author.
  50. Schmidt R., Schippers JH., Mieulet D., Watanabe M., Hoefgen R., Guiderdoni E., Mueller-Roeber B. (2014) SALT-RESPONSIVE ERF1 is a negative regulator of grain filling and gibberellin-mediated seedling establishment in rice. Molecular Plant, 7, 404-421.
  51. Watanabe M.*, Balazadeh S., Tohge T., Erban A., Giavalisco P., Kopka J., Mueller-Roeber B., Fernie AR., Hoefgen R. (2013) Comprehensive dissection of spatiotemporal metabolic shifts in primary, secondary, and lipid metabolism during developmental senescence in Arabidopsis. Plant Physiology, 162, 1290-1310. *corresponding author.
  52. Tohge T., Watanabe M., Hoefgen R., Fernie AR. (2013) Shikimate and phenylalanine biosynthesis in the green lineage. Frontiers in Plant Science, 4, 62.
  53. Tohge T., Watanabe M., Hoefgen R., Fernie AR. (2013) The evolution of phenylpropanoid metabolism in the green lineage. Critical Reviews in Biochemistry and Molecular Biology, 48, 123-152.
  54. Sieh D., Watanabe M., Devers EA., Brueckner F., Hoefgen R., Krajinski F. (2013) The arbuscular mycorrhizal symbiosis influences sulfur starvation responses of Medicago truncatula. New Phytologist, 197, 606-616.
  55. Tahir J.+, Watanabe M.+, Jing HC., Hunter DA., Tohge T., Nunes-Nesi A., Brotman Y., Fernie AR., Hoefgen R., Dijkwel PP. (2013) Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis The Plant Journal, 73, 118-130. +equal first author.
  56. Watanabe M., Hubberten HM., Saito K., Hoefgen R. (2010) General regulatory patterns of plant mineral nutrient depletion as revealed by serat quadruple mutants disturbed in cysteine synthesis. Molecular Plant, 3, 438-466.
  57. Watanabe M., Mochida K., Kato T., Tabata S., Yoshimoto N., Noji M., Saito K. (2008) Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis. The Plant Cell, 20, 2484-2496.
  58. Watanabe M., Kusano M., Oikawa A., Fukushima A., Noji M., Saito K. (2008) Physiological roles of the beta-substituted alanine synthase gene family in Arabidopsis. Plant Physiology, 146, 310-320.

査読付き国際会議論文

  1. Watanabe M., Hoefgen R. (2017) Expression profile of the serine acetyltransferase (SERAT) and O-acetylserine (thiol)lyase (OASTL) gene families in Arabidopsis. In “Sulfur Nutrition and Assimilation in Higher Plants: Fundamental, Environmental and Agricultural Aspects”, De Kok LJ., Hawkesford MJ., Haneklaus SH., Schnug E., eds: pp 31-38, Springer, Dordrecht.
  2. Hoefgen R, Watanabe M. (2017) Re-assessing systems biology approaches on analyzing sulfate metabolism. In “Sulfur Nutrition and Assimilation in Higher Plants: Fundamental, Environmental and Agricultural Aspects”, De Kok LJ., Hawkesford MJ., Haneklaus SH., Schnug E., eds: pp 123-133, Springer, Dordrecht.
  3. Watanabe M., Hoefgen R. (2015) Metabolic analysis of sulfur metabolism during leaf senescence. In “Molecular Physiology and Ecophysiology of Sulfur” De Kok LJ., Hawkesford MJ., Rennenberg H., Saito K., Schnug E., eds: pp 99-105, Springer, Dordrecht.
  4. Heyneke E., Watanabe M., Aarabi F., Hoefgen R. (2015) The CBL-SnRK3 network: connections to sulfur metabolism. In “Molecular Physiology and Ecophysiology of Sulfur” De Kok LJ., Hawkesford MJ., Rennenberg H., Saito K., Schnug E., eds: pp 145-152, Springer, Dordrecht.
  5. Hubberten HM., Watanabe M., Bielecka M., Heyneke E., Aarabi F., Hoefgen R. (2015) More than a substrate: the O-acetylserine responsive transcriptome. In “Molecular Physiology and Ecophysiology of Sulfur” De Kok LJ., Hawkesford MJ., Rennenberg H., Saito K., Schnug E., eds: pp 133-143, Springer, Dordrecht.
  6. Aarabi F., Hubberten HM., Heyneke E., Watanabe M., Hoefgen R. (2015) OAS cluster genes: a tightly co-regulated network. In “Molecular Physiology and Ecophysiology of Sulfur” De Kok LJ., Hawkesford MJ., Rennenberg H., Saito K., Schnug E., eds: pp 125-132, Springer, Dordrecht.
  7. Whitcomb SJ., Heyneke E., Aarabi F., Watanabe M., Hoefgen R. (2014) Mineral nutrient depletion affects plant development and crop yield. In “Nutrient Use Efficiency in Plants: Concepts and Approaches” Hawkesford MJ., Kopriva S., De Kok LJ., eds: pp 205-228, Springer, Dordrecht.
  8. Watanabe M., Hubberten HM., Hoefgen R. (2012) Plant response to mineral ion availability: transcriptome responses to sulfate, selenium and iron. In “Sulfur Metabolism in Plants, Proceedings of the International Sulfur Workshop” De Kok LJ., Tabe L., Tausz M., Hawkesford MJ., Hoefgen R., McManus MT., Norton RM., Rennenberg H., Saito K., Schnug E., eds: pp 123-134, Springer, Dordrecht.
  9. Watanabe M., Kusano M., Oikawa A., Fukushima A., Mochida K., Kato T., Tabata S., Yoshimoto N., Noji M., Saito K. (2009) Cysteine biosynthesis in Arabidopsis: comprehensive reverse genetic study on the functions of BSAS and SERAT gene families. In "Sulfur Metabolism in Plants Regulatory Aspects Significance of Sulfur in the Food Chain, Agriculture and the Environment" Sirko A., De Kok LJ., Haneklaus S., Hawkesford MJ., Rennenberg H., Saito K., Schnug E., Stulen I., eds: pp 201-206, Backhuys Publishers, Leiden.
  10. Noji M., Higashi Y., Watanabe M., Saito K. (2005) T-DNA insertion mutant of ATP sulfurylase, the first enzyme of sulfur assimilatory metabolism, in Arabidopsis thaliana. In “Sulfur Transport and Assimilation in Plants in the Post Genomics Eras” Saito K., De Kok LJ., Stulen I., Hawkesford MJ., Schnug E., Sirko A., Rennenberg H., eds: pp 81-82, Backhuys Publishers, Leiden.
  11. Watanabe M., Noji M., Kusano M., Kato T., Tabata S., Saito K. (2005) Functional analysis of serine acetyltransferase genes (Serat) involved in sulfur assimilation in Arabidopsis thaliana. In “Sulfur Transport and Assimilation in Plants in the Post Genomics Eras” Saito K., De Kok LJ., Stulen I., Hawkesford MJ., Schnug E., Sirko A., Rennenberg H., eds: pp 99-101, Backhuys Publishers, Leiden.

Others (総説・その他)

  1. Watanabe M., Hubberten HM., Saito K., Hoefgen R. (2015) Chapter 11: Serine acetyltransferase. In “Amino Acids in Higher Plants” D'Mello JPF., eds: pp 195-218, CPI Group (UK) Ltd, Croydon.

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