Elucidating the homeostatic mechanism of tissue cell population

Gene Regulation Research・ Assistant Professor ・ Ryutaro Akiyama

The tissue homeostasis maintains the homogeneity, morphology, and function of the tissue by suppressing or eliminating abnormal cells that continuously arise in tissues. We have studied the mechanism of homeostasis with some experimental models. In this review, I introduce two examples from our recent studies. First, I present a study using a somite formation model in mouse embryos to show how vertebral malformations occur. Furthermore, I describe a study that used an epithelial cell culture system to elucidate a novel mechanism for extruding abnormal cells from the tissue.


Figure 1. Segmentation of somite and vertebra in mouse embryo.
(a) Skeletal preparations of mouse. (b) Establishment of anterior-posterior polarity during somite formation. (c) Anterior-posterior polarity within the somite and the corresponding vertebral position.

Ryutaro Akiyama NAIST Edge BIO, e0015. (2023).

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