{"id":11,"date":"2024-11-13T13:15:29","date_gmt":"2024-11-13T04:15:29","guid":{"rendered":"https:\/\/bsw3.naist.jp\/LabsW\/matsuda\/?page_id=11"},"modified":"2025-06-10T13:00:18","modified_gmt":"2025-06-10T04:00:18","slug":"publication","status":"publish","type":"page","link":"https:\/\/bsw3.naist.jp\/matsuda\/publication\/","title":{"rendered":"\u767a\u8868\u8ad6\u6587"},"content":{"rendered":"\n

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  1. Shuzo Matsubara, Kanae Matsuda-Ito, Haruka Sekiryu, Hiroyoshi Doi, Takumi Nakagawa, Naoya Murao, Hisanobu Oda, KinichiNakashima, and Taito Matsuda<\/strong>.Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation.EMBO J.<\/strong>.\u00a02025 Jun 3.\u00a0doi: 10.1038\/s44318-025-00455-8.\u00a0Online ahead of print.<\/li>\n\n\n\n
  2. Irie T., Matsuda T* (co-corresponding author)<\/u><\/strong>, Hayashi Y., Matsuda-Ito K., Kamiya A., Masuda T., Prinz M., Kira J.I. & Nakashima K*. Direct neuronal conversion of microglia\/macrophages reinstates neurological function after stroke. Proc Natl Acad Sci USA<\/strong> 120, e2307972120, 2023.<\/li>\n\n\n\n
  3. Irie T#., Matsuda-Ito K# (equal first authorship)<\/u><\/strong>., Matsuda T* (co-corresponding author)<\/u><\/strong>., Masuda T., Prinz M., Isobe N. & Nakashima K*. Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression. Genes Cells<\/strong> 28, 526-534, 2023.<\/li>\n\n\n\n
  4. Matsuda-Ito K#<\/u><\/strong>., Matsuda T#* (equal first authorship, co-corresponding author)<\/u><\/strong>. & Nakashima K*. Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types. Scientific Reports<\/strong> 12, 17980, 2022.<\/li>\n\n\n\n
  5. Doi H#., Matsuda T#* (equal first authorship, co-corresponding author)<\/u><\/strong>., Sakai A., Matsubara S., Hoka S., Yamaura K. & Nakashima K*. Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition. Proc Natl Acad Sci USA<\/strong> 18, e2107596118, 2021.<\/li>\n\n\n\n
  6. Matsuda T * (co-corresponding author)<\/u><\/strong>., Irie T., Katsurabayashi S., Hayashi Y., Nagai T., Hamazaki N., Adefuin AMD., Miura F., Ito T., Kimura H., Shirahige K., Takeda T., Iwasaki K., Imamura T. & Nakashima K*. Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. Neuron<\/strong> 101, 472-485, 2019.<\/li>\n\n\n\n
  7. Murao N., Matsubara S., Matsuda T<\/u><\/strong>., Noguchi H., Mutoh T., Mutoh M., Koseki H., Namihira M. & Nakashima K. Np95\/Uhrf1 regulates tumor suppressor gene expression of neural stem\/precursor cells, contributing to neurogenesis in the adult mouse brain. Neurosci Res<\/strong> 143, 31-43, 2019.<\/li>\n\n\n\n
  8. Sakai A#., Matsuda T# (equal first authorship)<\/u><\/strong>., Doi H., Nagaishi Y., Kato K. & Nakashima K. Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice. Proc Natl Acad Sci USA<\/strong> 115, 4270-4275, 2018.<\/li>\n\n\n\n
  9. Uezono N., Zhu Y., Fujimoto Y., Yasui T., Matsuda T<\/u><\/strong>., Nakajo M., Abematsu M., Setoguchi T., Mori S., Takahashi H.K., Komiya S., Nishibori M. & Nakashima K. Prior treatment with anti-High Mobility Group Box-1 antibody boosts human neural stem cell transplantation-mediated functional recovery after spinal cord injury. Stem Cells<\/strong> 36, 737-750, 2018.\u3000<\/li>\n\n\n\n
  10. Kimura A., Matsuda T* (co-corresponding author)<\/u><\/strong>., Sakai A., Murao N. & Nakashima K*. HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells. Deve Dyn<\/strong> 247, 229-238, 2018.\u3000<\/li>\n\n\n\n
  11. Brulet R., Matsuda T<\/u><\/strong>., Zhang L., Miranda C., Giacca M., Kaspar B.K., Nakashima K. & Hsieh J. NEUROD1 instructs neuronal conversion in non-reactive astrocytes. Stem Cell Reports<\/strong> 8, 1506\u20131515, 2017.\u3000<\/li>\n\n\n\n
  12. Yasui T., Uezono N., Nakashima H, Noguchi H., Matsuda T<\/u><\/strong>., Noda-Andoh T., Okano H. & Nakashima K. Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells. Stem Cell Reports<\/strong> 8, 1743\u20131756, 2017.\u3000<\/li>\n\n\n\n
  13. Noguchi H., Murao N., Kimura A., Matsuda T<\/u><\/strong>., Namihira M. & Nakashima K. DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus. J. Neurosci<\/strong> 36, 6050\u20136068, 2016.\u3000<\/li>\n\n\n\n
  14. Matsuda T<\/u><\/strong>., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K. TLR9 signaling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun<\/strong> 6, 6514, 2015.<\/li>\n\n\n\n
  15. Noguchi H., Kimura A., Murao N., Matsuda T<\/u><\/strong>., Namihira M. & Nakashima K. Expression of DNMT1 in neural stem\/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. Neurosci Res <\/strong>95, 1-11, 2015.<\/li>\n\n\n\n
  16. Murao N., Matsuda T<\/u><\/strong>., Noguchi H., Koseki H., Namihira M. & Nakashima K. Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem\/precursor cells. Neurogenesis<\/strong> 1, 1-11, 2014.<\/li>\n\n\n\n
  17. Yuasa K#., Matsuda T# (equal first authorship)<\/u><\/strong>. & Tsuji A. Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase I\u03b1. Cell Signal<\/strong> 23, 1179-1187, 2011.\u3000<\/li>\n<\/ol>\n\n\n\n

    \u82f1\u8a9e\u7dcf\u8aac<\/h3>\n\n\n\n
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    1. Umeyama T., Matsuda T*<\/u><\/strong>. & Nakashima K. Lineage Reprogramming: Genetic, Chemical, and Physical Cues for Cell Fate Conversion with a Focus on Neuronal Direct Reprogramming and Pluripotency Reprogramming. Cells <\/strong>13, 707, 2024.<\/li>\n\n\n\n
    2. Iwamoto M. & Matsuda T*<\/u><\/strong>. Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain. Neural Regeneration Res <\/strong>19, 711-712, 2024.<\/li>\n\n\n\n
    3. Matsubara S., Matsuda T* (co-corresponding author)<\/u><\/strong>. & Nakashima K*.  Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors. Cells<\/strong> 10, 1145, 2021.<\/li>\n\n\n\n
    4. Sekiryu H. & Matsuda T*<\/u><\/strong>. In vivo direct reprogramming as a therapeutic strategy for brain and retina repair. Neural Regeneration<\/strong> Res <\/strong>16, 1998-1999, 2021.<\/li>\n\n\n\n
    5. Matsuda T* (co-corresponding author)<\/u><\/strong>. & Nakashima K. Natural and forced neurogenesis in the adult brain: Mechanisms and their possible application to treat neurological disorders. Neuroscience Res<\/strong> 166, 1-11, 2021.<\/li>\n\n\n\n
    6. Matsuda T<\/u><\/strong>. & Nakashima K. Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus. Neurogenesis<\/strong> 2, 2015.<\/li>\n\n\n\n
    7. MuhChyi C., Juliandi B., Matsuda T<\/u><\/strong>. & Nakashima K. Epigenetic regulation of neural stem cell fate during corticogenesis. Int J Dev Neurosci<\/strong> 6, 424-433, 2013.<\/li>\n<\/ol>\n\n\n\n

      \u65e5\u672c\u8a9e\u8457\u66f8<\/h3>\n\n\n\n
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      1. \u677e\u7530\u6cf0\u6597\u3001\u5165\u6c5f\u525b\u53f2\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30df\u30af\u30ed\u30b0\u30ea\u30a2\/\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304b\u3089\u795e\u7d4c\u7d30\u80de\u3078\u306e\u76f4\u63a5\u5206\u5316\u8ee2\u63db\u306f\u8133\u6897\u585e\u5f8c\u306e\u795e\u7d4c\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u3001\u5b9f\u9a13\u533b\u5b66 Vol.42\u3001No.3\u3001449-452\u30012024\u5e74<\/li>\n\n\n\n
      2. \u5ca9\u672c\u660c\u548c\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306b\u3088\u308b\u795e\u7d4c\u518d\u751f\u3001\u533b\u5b66\u306e\u3042\u3086\u307f\u3000Vol.284\u3001No.11\u3001869-874 \u30012023\u5e74<\/li>\n\n\n\n
      3. \u677e\u7530\u6cf0\u6597\u3001\u571f\u4e95\u6d69\u7fa9\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u5e7c\u82e5\u671f\u306e\u9ebb\u9154\u85ac\u66dd\u9732\u304c\u5c06\u6765\u7684\u306a\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3092\u8a98\u767a\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3001 \u5b9f\u9a13\u533b\u5b66Vol.40\u3001No.4\u3001588-2591\u30012022\u5e74<\/li>\n\n\n\n
      4. \u677e\u7530\u82b1\u83dc\u6c5f\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30c0\u30a4\u30ec\u30af\u30c8\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306b\u3088\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304b\u3089\u795e\u7d4c\u7d30\u80de\u3078\u306e\u8a98\u5c0e\u3001\u5225\u518a\u533b\u5b66\u306e\u3042\u3086\u307f\u3001\u533b\u6b6f\u85ac\u51fa\u7248\u682a\u5f0f\u4f1a\u793e\u30012021\u5e74<\/li>\n\n\n\n
      5. \u677e\u7530\u82b1\u83dc\u6c5f\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30c0\u30a4\u30ec\u30af\u30c8\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306b\u3088\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304b\u3089\u795e\u7d4c\u7d30\u80de\u3078\u306e\u8a98\u5c0e\u3001\u9031\u520a\u533b\u5b66\u306e\u3042\u3086\u307f\u3001\u533b\u6b6f\u85ac\u51fa\u7248\u682a\u5f0f\u4f1a\u793e\u30012020\u5e74<\/li>\n\n\n\n
      6. \u677e\u7530\u82b1\u83dc\u6c5f\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30c0\u30a4\u30ec\u30af\u30c8\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306b\u3088\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304b\u3089\u795e\u7d4c\u7d30\u80de\u3078\u306e\u904b\u547d\u8ee2\u63db\u3001\u30c0\u30a4\u30ec\u30af\u30c8\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3001\u30a8\u30cc\u30fb\u30c6\u30a3\u30fc\u30fb\u30a8\u30b9 2020\u5e74<\/li>\n\n\n\n
      7. \u5165\u6c5f\u525b\u53f2\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00\uff1b\u3000\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\uff0e\u5b9f\u9a13\u533b\u5b66\u5225\u518a(2020.11)105-112<\/li>\n\n\n\n
      8. \u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304b\u3089\u795e\u7d4c\u7d30\u80de\u3078\u306e\u30c0\u30a4\u30ec\u30af\u30c8\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3001\u5b9f\u9a13\u533b\u5b66, Vol.37 No.17 \u7f8a\u571f\u793e\u30012019\u5e74<\/li>\n\n\n\n
      9. \u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304b\u3089\u6a5f\u80fd\u7684\u306a\u795e\u7d4c\u7d30\u80de\u3078\u306e\u30c0\u30a4\u30ec\u30af\u30c8\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3001\u5b9f\u9a13\u533b\u5b66, Vol.37 No.8, \u7f8a\u571f\u793e\u30012019\u5e74<\/li>\n\n\n\n
      10. \u5742\u4e95\u6df3\u5f66\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u3066\u3093\u304b\u3093\u767a\u4f5c\u306b\u3051\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3001Clinical Neuroscience Vol.33 No.12, 1373-1376, \u4e2d\u5916\u533b\u5b66\u793e, 2015\u5e74<\/li>\n\n\n\n
      11. \u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00; \u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306b\u304a\u3051\u308b\u81ea\u7136\u514d\u75ab\u53d7\u5bb9\u4f53TLR9\u30b7\u30b0\u30ca\u30eb\u306f\u6210\u4f53\u30cb\u30e5\u30fc\u30ed\u30f3\u65b0\u751f\u306e\u6052\u5e38\u6027\u3092\u4fdd\u8a3c\u3059\u308b\u3001\u5b9f\u9a13\u533b\u5b66 33\u3001vol.13\u3001\u7f8a\u571f\u793e\u3001 2015\u5e74<\/li>\n\n\n\n
      12. \u5b89\u4e95\u5fb9\u90ce\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e0a\u8597\u76f4\u5f18\u3001\u4e2d\u5cf6\u6b3d\u4e00\uff1b\u795e\u7d4c\u518d\u751f\u533b\u7642\u306b\u304a\u3051\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3000<\/strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u7523\u696d\u5fdc\u7528\u3001350-361\u3001\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248\u30012014\u5e74<\/li>\n\n\n\n
      13. \u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00\uff1b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3000\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u304b\u3089\u9ad8\u6b21\u751f\u547d\u6a5f\u80fd\u307e\u3067\u3001pp151-168\u3001 \u5316\u5b66\u540c\u4eba\u30012013\u5e74<\/li>\n\n\n\n
      14. \u4e0a\u8597\u76f4\u5f18\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00;\u907a\u4f1d\u5b50\u533b\u5b66MOOK 25 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u75c5\u6c17\u3001171-177\u3001\u30e1\u30c7\u30a3\u30ab\u30eb \u30c9\u30a5\u30012013\u5e74<\/li>\n\n\n\n
      15. \u4e0a\u8597\u76f4\u5f18\u3001\u677e\u7530\u6cf0\u6597\u3001\u4e2d\u5cf6\u6b3d\u4e00\uff1b\u5b9f\u9a13\u533b\u5b66 30\u3001 pp2932-2938\u3001 \u7f8a\u571f\u793e\u3001 2012\u5e74<\/li>\n<\/ol>\n\n\n\n

        \u8868\u5f70\u30fb\u53d7\u8cde<\/h3>\n\n\n\n
          \n
        1. \u4ee4\u548c2\u5e74\u5ea6\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u7814\u7a76\u4f1a\u5968\u52b1\u8cde<\/li>\n\n\n\n
        2. \u4ee4\u548c2\u5e74\u5ea6\u65e5\u672c\u795e\u7d4c\u79d1\u5b66\u4f1a\u5968\u52b1\u8cde<\/li>\n\n\n\n
        3. \u7b2c12\u56de\u6210\u4f53\u8133\u30cb\u30e5\u30fc\u30ed\u30f3\u65b0\u751f\u61c7\u8ac7\u4f1a\u3001\u6700\u512a\u79c0\u6f14\u984c\u8cde<\/li>\n\n\n\n
        4. \u7b2c32\u56de\u4e95\u4e0a\u7814\u7a76\u5968\u52b1\u8cde<\/li>\n\n\n\n
        5. \u7b2c11\u56de\u6210\u4f53\u8133\u30cb\u30e5\u30fc\u30ed\u30f3\u65b0\u751f\u61c7\u8ac7\u4f1a\u3001\u512a\u79c0\u6f14\u984c\u8cde<\/li>\n\n\n\n
        6. SFN2015 travel award<\/li>\n\n\n\n
        7. ISSCR 2012 travel award<\/li>\n\n\n\n
        8. ISSCR 2012 Poster Teaser<\/li>\n<\/ol>\n\n\n\n

          <\/p>\n","protected":false},"excerpt":{"rendered":"

          \u539f\u8457\u8ad6\u6587 \u82f1\u8a9e\u7dcf\u8aac \u65e5\u672c\u8a9e\u8457\u66f8 \u8868\u5f70\u30fb\u53d7\u8cde<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":0,"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"wp:attachment":[{"href":"https:\/\/bsw3.naist.jp\/matsuda\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}