Shuzo Matsubara, Kanae Matsuda-Ito, Haruka Sekiryu, Hiroyoshi Doi, Takumi Nakagawa, Naoya Murao, Hisanobu Oda, KinichiNakashima, and Taito Matsuda.Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation.EMBO J.. 2025 Jun 3. doi: 10.1038/s44318-025-00455-8. Online ahead of print.
Irie T., Matsuda T* (co-corresponding author), Hayashi Y., Matsuda-Ito K., Kamiya A., Masuda T., Prinz M., Kira J.I. & Nakashima K*. Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke. Proc Natl Acad Sci USA 120, e2307972120, 2023.
Irie T#., Matsuda-Ito K# (equal first authorship)., Matsuda T* (co-corresponding author)., Masuda T., Prinz M., Isobe N. & Nakashima K*. Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression. Genes Cells 28, 526-534, 2023.
Matsuda-Ito K#., Matsuda T#* (equal first authorship, co-corresponding author). & Nakashima K*. Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types. Scientific Reports 12, 17980, 2022.
Doi H#., Matsuda T#* (equal first authorship, co-corresponding author)., Sakai A., Matsubara S., Hoka S., Yamaura K. & Nakashima K*. Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition. Proc Natl Acad Sci USA 18, e2107596118, 2021.
Matsuda T * (co-corresponding author)., Irie T., Katsurabayashi S., Hayashi Y., Nagai T., Hamazaki N., Adefuin AMD., Miura F., Ito T., Kimura H., Shirahige K., Takeda T., Iwasaki K., Imamura T. & Nakashima K*. Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. Neuron 101, 472-485, 2019.
Murao N., Matsubara S., Matsuda T., Noguchi H., Mutoh T., Mutoh M., Koseki H., Namihira M. & Nakashima K. Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Neurosci Res 143, 31-43, 2019.
Sakai A#., Matsuda T# (equal first authorship)., Doi H., Nagaishi Y., Kato K. & Nakashima K. Ectopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult mice. Proc Natl Acad Sci USA 115, 4270-4275, 2018.
Uezono N., Zhu Y., Fujimoto Y., Yasui T., Matsuda T., Nakajo M., Abematsu M., Setoguchi T., Mori S., Takahashi H.K., Komiya S., Nishibori M. & Nakashima K. Prior treatment with anti-High Mobility Group Box-1 antibody boosts human neural stem cell transplantation-mediated functional recovery after spinal cord injury. Stem Cells 36, 737-750, 2018.
Kimura A., Matsuda T* (co-corresponding author)., Sakai A., Murao N. & Nakashima K*. HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells. Deve Dyn 247, 229-238, 2018.
Brulet R., Matsuda T., Zhang L., Miranda C., Giacca M., Kaspar B.K., Nakashima K. & Hsieh J. NEUROD1 instructs neuronal conversion in non-reactive astrocytes. Stem Cell Reports 8, 1506–1515, 2017.
Yasui T., Uezono N., Nakashima H, Noguchi H., Matsuda T., Noda-Andoh T., Okano H. & Nakashima K. Hypoxia epigenetically confers astrocytic differentiation potential on human pluripotent cell-derived neural precursor cells. Stem Cell Reports 8, 1743–1756, 2017.
Noguchi H., Murao N., Kimura A., Matsuda T., Namihira M. & Nakashima K. DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus. J. Neurosci 36, 6050–6068, 2016.
Matsuda T., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K. TLR9 signaling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus. Nat Commun 6, 6514, 2015.
Noguchi H., Kimura A., Murao N., Matsuda T., Namihira M. & Nakashima K. Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. Neurosci Res 95, 1-11, 2015.
Murao N., Matsuda T., Noguchi H., Koseki H., Namihira M. & Nakashima K. Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells. Neurogenesis 1, 1-11, 2014.
Yuasa K#., Matsuda T# (equal first authorship). & Tsuji A. Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα. Cell Signal 23, 1179-1187, 2011.
英語総説
Umeyama T., Matsuda T*. & Nakashima K. Lineage Reprogramming: Genetic, Chemical, and Physical Cues for Cell Fate Conversion with a Focus on Neuronal Direct Reprogramming and Pluripotency Reprogramming. Cells 13, 707, 2024.
Iwamoto M. & Matsuda T*. Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain. Neural Regeneration Res 19, 711-712, 2024.
Matsubara S., Matsuda T* (co-corresponding author). & Nakashima K*. Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors. Cells 10, 1145, 2021.
Sekiryu H. & Matsuda T*. In vivo direct reprogramming as a therapeutic strategy for brain and retina repair. Neural RegenerationRes 16, 1998-1999, 2021.
Matsuda T* (co-corresponding author). & Nakashima K. Natural and forced neurogenesis in the adult brain: Mechanisms and their possible application to treat neurological disorders. Neuroscience Res 166, 1-11, 2021.
Matsuda T. & Nakashima K. Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus. Neurogenesis 2, 2015.
MuhChyi C., Juliandi B., Matsuda T. & Nakashima K. Epigenetic regulation of neural stem cell fate during corticogenesis. Int J Dev Neurosci 6, 424-433, 2013.