{"id":172,"date":"2025-03-05T11:03:53","date_gmt":"2025-03-05T02:03:53","guid":{"rendered":"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/?page_id=172"},"modified":"2026-02-27T03:55:28","modified_gmt":"2026-02-26T18:55:28","slug":"home","status":"publish","type":"page","link":"https:\/\/bsw3.naist.jp\/kimata\/en\/home\/","title":{"rendered":"HOME"},"content":{"rendered":"\n
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Laboratory of
Organelle Control<\/h1>\n<\/div>\n\n\n\n
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RESRECH<\/a><\/h3>\n\n\n\n
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PUBLICATIONS<\/a><\/h3>\n\n\n\n
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MEMBERS<\/a><\/h3>\n\n\n\n
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SNAP SHOTS<\/a><\/h3>\n\n\n\n
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We focus on the functional regulation of the endoplasmic reticulum (ER), which is a membrane-enclosed organelle commonly carried by eukaryotic cells, using yeast cells as a model organism. Our research results will contribute to the development of yeast strains carrying an enforced ER, which can be used as commercially valuable biomolecules.<\/p>\n\n\n\n

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Fluorescence microscopy image of a yeast cell<\/strong><\/strong><\/p>\n\n\n\n

Nuclei (blue), ER (red), and the ER-stress sensor Ire1 (green) were visualized.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Research topics<\/strong><\/h2>\n\n\n\n
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  • Cellular mechanism to control organelle size, morphology, and function in response to environmental change<\/li>\n\n\n\n
  • Heterogenous biomolecule production by yeast cells<\/li>\n\n\n\n
  • Stress response upon yeast ethanol fermentation<\/li>\n\n\n\n
  • Thermotolerant yeast Kluyveromyces marxianus<\/em><\/li>\n\n\n\n
  • Approach to human diseases using yeast as a model organism<\/li>\n<\/ul>\n\n\n\n

    We are a newly launched laboratory started in April 2025.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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    Why do we study on yeasts?<\/strong><\/h2>\n\n\n\n

    Yeast Saccharomyces cerevisiae<\/em> is a unicellular eukaryote that has a strong ability to perform ethanol fermentation, which is widely applied for production of alcoholic beverages, breads, and bioethanol. It should be noted that the S. cerevisiae<\/em> genome, with a size of which is 13.3 Mb, is the first eukaryotic genome to be completely sequenced. Various techniques are available for genetic engineering of S. cerevisiae <\/em>cells. In addition, S. cerevisiae<\/em> cells can grow rapidly and inexpensively. Therefore, S. cerevisiae<\/em> serves as a valuable model for basic researches on the biological phenomena observed in other eukaryotic species. Moreover, because of these advantageous features, S. cerevisiae<\/em> are used for the production of a wide variety of commercially valuable metabolites and heterogeneous proteins. Human secretory proteins, such as insulin and cytokines, made by yeasts are used as biopharmaceuticals to treat human diseases.<\/p>\n<\/div>\n\n\n\n

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    Feature and usage of yeast S. cerevisiae<\/em><\/p>\n<\/div>\n<\/div>\n\n\n\n

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    RESRECH PUBLICATIONS MEMBERS SNAP SHOTS<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"on","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"on","footnotes":""},"class_list":["post-172","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/pages\/172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/comments?post=172"}],"version-history":[{"count":0,"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/pages\/172\/revisions"}],"wp:attachment":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/media?parent=172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}