{"id":126,"date":"2025-02-27T10:13:52","date_gmt":"2025-02-27T01:13:52","guid":{"rendered":"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/?page_id=126"},"modified":"2026-02-27T05:22:06","modified_gmt":"2026-02-26T20:22:06","slug":"research","status":"publish","type":"page","link":"https:\/\/bsw3.naist.jp\/kimata\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull\" style=\"min-height:300px;aspect-ratio:unset;\"><img decoding=\"async\" width=\"2000\" height=\"779\" class=\"wp-block-cover__image-background wp-image-29\" alt=\"\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/mainimage.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/mainimage.jpg 2000w, https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/mainimage-1536x598.jpg 1536w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-nv-site-bg-background-color has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group\" style=\"padding-right:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h1 class=\"wp-block-heading has-text-align-left has-nv-text-dark-bg-color has-text-color\">\u7814\u7a76\u5185\u5bb9<\/h1>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull\" style=\"min-height:600px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-nv-light-bg-background-color has-background-dim-100 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u80cc\u666f\uff1a\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068Unfolded protein response (UPR)<\/h2>\n\n\n\n<p>\u5c0f\u80de\u4f53\u306f\u3001\u52d5\u690d\u7269\u305d\u3057\u3066\u9175\u6bcd\u306a\u3069\u3001\u3042\u3089\u3086\u308b\u771f\u6838\u751f\u7269\u7d30\u80de\u304c\u6301\u3064\u30aa\u30eb\u30ac\u30cd\u30e9\u3067\u3059\u3002\u3000\u305d\u306e\u5b9f\u4f53\u306f\u6241\u5e73\u3042\u308b\u3044\u306f\u30c1\u30e5\u30fc\u30d6\u72b6\u306e\u5f62\u3092\u3057\u305f\u888b\u3067\u3042\u308a\u3001\u7d30\u80de\u5916\u306b\u5206\u6ccc\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u4ed6\u306e\u30aa\u30eb\u30ac\u30cd\u30e9\u3067\u50cd\u304f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u88fd\u9020\u5de5\u5834\u3068\u3057\u3066\u50cd\u304d\u307e\u3059\u3002\u3000\u9175\u6bcd\u306f\u7d04\uff16\u5343\u7a2e\u985e\u3001\u9ad8\u7b49\u52d5\u690d\u7269\u306f\u6570\u4e07\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308a\u3001\u305d\u306e\u4e2d\u306e\u304a\u3088\u305d\uff13\u5272\u304c\u5c0f\u80de\u4f53\u3078\u3068\u904b\u3073\u8fbc\u307e\u308c\u307e\u3059\u3002\u3000\u5c0f\u80de\u4f53\u306e\u5185\u90e8\u306b\u306f\u8907\u6570\u306e\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u304c\u5b58\u5728\u3057\u3066\u304a\u308a\u3001\u5c0f\u80de\u4f53\u306b\u9001\u3089\u308c\u3066\u304d\u305f\u65b0\u751f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6298\u308a\u7573\u307f\u307e\u3059\u3002\u3000\u305d\u3057\u3066\u3001\u6b63\u3057\u304f\u6298\u308a\u7573\u307e\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u307f\u5c0f\u80de\u4f53\u304b\u3089\u904b\u3073\u51fa\u3055\u308c\u308b\u306e\u3067\u3059\u3002\u3000\u307e\u305f\u3001\u5c0f\u80de\u4f53\u306e\u3082\u3046\u4e00\u3064\u306e\u5f79\u5272\u306f\u3001\u30ea\u30f3\u8102\u8cea\u3084\u6cb9\u8102\uff08\u4e2d\u6027\u8102\u8cea\uff09\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u8102\u8cea\u985e\u306e\u751f\u5408\u6210\u306e\u5834\u3068\u306a\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized has-custom-border\"><img decoding=\"async\" width=\"423\" height=\"237\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/research1.png\" alt=\"\" class=\"wp-image-127\" style=\"border-radius:0px;width:555px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color has-medium-font-size wp-elements-6caac727ead4224a97a0098dcfe251d6\"><strong>\u9175\u6bcd\u7d30\u80de\u306e\u5c0f\u80de\u4f53<\/strong><\/p>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color wp-elements-3247845bfab918195e1ceca8e1049929\">\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30b5\u30f3\u30b4\u7531\u6765RFP\uff09\u304c\u878d\u5408\u3057\u305f\u5c0f\u80de\u4f53\u30bf\u30f3\u30d1\u30af\u8ceaElo2\u3092\u767a\u73fe\u3059\u308b\u9175\u6bcd(<em>Saccharomyces cerevisiae<\/em>)\u7d30\u80de<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5c0f\u80de\u4f53\u306e\u6a5f\u80fd\u4e0d\u5168\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u547c\u3070\u308c\u3001\u5c0f\u80de\u4f53\u5185\u3078\u306e\u6298\u308a\u7573\u307f\u4e0d\u5168\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u3092\u4f34\u3044\u307e\u3059\u3002\u3000\u7570\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b58\u5728\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u308a\u3001\u8a8d\u77e5\u75c7\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3059\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3068\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u306e\u95a2\u9023\u306f\u591a\u304f\u306e\u7814\u7a76\u8005\u306b\u3088\u3063\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3000\u307e\u305f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u3092\u59a8\u3052\u308b\u5316\u5b66\u7269\u8cea\u3082\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"500\" height=\"300\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/research2.png\" alt=\"\" class=\"wp-image-128\" style=\"width:548px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color has-medium-font-size wp-elements-f4ecb488d7e7cb1bd690f9d3227eef61\"><strong>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9<\/strong><\/p>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color wp-elements-c3f1ab54ac8b1929d759604615a45c7c\">\u901a\u5e38\u72b6\u614b\u3067\u306f\u3001\u30ea\u30dc\u30be\u30fc\u30e0\u304b\u3089\u5c0f\u80de\u4f53\u306b\u9001\u308a\u8fbc\u307e\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u88dc\u52a9\u3092\u53d7\u3051\u3066\u6298\u308a\u7573\u307e\u308c\u305f\u5f8c\u3001\u8f38\u9001\u5c0f\u80de\u306b\u8a70\u3081\u8fbc\u307e\u308c\u3001\u30b4\u30eb\u30b8\u4f53\u3092\u7d4c\u3066\u7d30\u80de\u8868\u9762\u3084\u4ed6\u306e\u30aa\u30eb\u30ac\u30cd\u30e9\u306b\u904b\u3070\u308c\u308b\u3002\u3000\u4e00\u65b9\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u3067\u306f\u3001\u6298\u308a\u7573\u307e\u308c\u306a\u304b\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5c0f\u80de\u4f53\u306b\u84c4\u7a4d\u3057\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u3068\u3057\u3066\u7d30\u80de\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u308b\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<p>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u6297\u3046\u305f\u3081\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u5909\u52d5\u304cUnfolded Protein Response (UPR)\u3067\u3059\u3002\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u3066\u3001\u5c0f\u80de\u4f53\u3067\u50cd\u304f\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306a\u3069\u306e\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u304c\u7de9\u548c\u3055\u308c\u307e\u3059\u3002\u3000\u52d5\u690d\u7269\u3092\u542b\u3080\u3042\u3089\u3086\u308b\u771f\u6838\u751f\u7269\u3067UPR\u306f\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306f\u9175\u6bcd(<em>Saccharomyces cerevisiae<\/em>)\u3092\u30e2\u30c7\u30eb\u751f\u7269\u3068\u3057\u305f\u7814\u7a76\u304c\u5148\u884c\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>Ire1\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u3000\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u3066Ire1\u306f\u6d3b\u6027\u5316\u3057\u3066\u3001RNA\u5207\u65ad\u9175\u7d20\u3068\u3057\u3066\u50cd\u304d\u307e\u3059\u3002\u3000\u9175\u6bcd\u3067\u306f\u305d\u306e\u6a19\u7684\u306f<em>HAC1<\/em> mRNA\u3067\u3059\u3002\u3000Ire1\u306b\u3088\u3063\u3066\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3055\u308c\u305f<em>HAC1<\/em> mRNA\u306f\u6838\u5185\u8ee2\u5199\u56e0\u5b50\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7ffb\u8a33\u3055\u308c\u3001UPR\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u8a98\u5c0e\u3092\u53f8\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"500\" height=\"300\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/research3.png\" alt=\"\" class=\"wp-image-129\" style=\"width:545px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color has-medium-font-size wp-elements-50f25979d2e7713fe2285b6c4357b826\"><strong>\u9175\u6bcd\u306eUPR<\/strong><\/p>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color wp-elements-d814b02e666851fabd052c7f3eaed1bf\">Ire1\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u3066\u81ea\u5df1\u4f1a\u5408\u3057\u3001RNA\u5207\u65ad\u9175\u7d20(RNase)\u3068\u3057\u3066\u50cd\u304f\u3002\u305d\u3057\u3066<em>HAC1<\/em> mRNA\u3092\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u3088\u308a\u6210\u719f\u3055\u305b\u3001UPR\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u5909\u52d5\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-nv-site-bg-background-color has-background-dim-100 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u6210\u679c\uff11:<\/strong> \u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u305fIre1\u306e\u591a\u91cf\u4f53\u5316<\/h2>\n\n\n\n<p>\u79c1\u305f\u3061\u306f\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u3066Ire1\u304c\u81ea\u5df1\u4f1a\u5408\u3057\u3066\u5de8\u5927\u306a\u591a\u91cf\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3000Ire1\u591a\u91cf\u4f53\u306f\u5f37\u3044RNA\u5207\u65ad\u6d3b\u6027\u3092\u793a\u3057\u3001UPR\u3092\u60f9\u8d77\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"538\" height=\"355\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/research4.png\" alt=\"\" class=\"wp-image-131\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color has-medium-font-size wp-elements-91c1893b61b172cec043c2711b74a420\"><strong>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u305fIre1\u306e\u5c40\u5728\u5909\u5316<\/strong><\/p>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color wp-elements-2bd3ac50f67dd660863870c38b6dc1bd\">\u9175\u6bcd\u7d30\u80de\u5185\u306eIre1\u306e\u5c40\u5728\u3092\u3001\u86cd\u5149\u6297\u4f53\u67d3\u8272\u6cd5\u306b\u3088\u3063\u3066\u53ef\u8996\u5316\u3057\u305f\u3002\u30b9\u30c8\u30ec\u30b9\u304c\u7121\u3044\u72b6\u614b\u3067\u306fIre1\u306f\u5c0f\u80de\u4f53\u5168\u4f53\u306b\u5e83\u304c\u3063\u3066\u3044\u308b\u304c\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u3067\u306f\uff08\u3053\u306e\u5834\u5408\u306f\u3001DTT\u3092\u57f9\u5730\u306b\u52a0\u3048\u3001\u5c0f\u80de\u4f53\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u3092\u963b\u5bb3\u3057\u305f\uff09\u3001Ire1\u306f\u5927\u304d\u306a\u591a\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3066\u70b9\u72b6\u306e\u5c40\u5728\u3092\u793a\u3059\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u6210\u679c2: <\/strong>Ire1\u304c\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u77e5\u3059\u308b\u4ed5\u7d44\u307f<\/h2>\n\n\n\n<p>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u50cd\u304fIre1\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u4ed5\u7d44\u307f\u3067\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u77e5\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u5c0f\u80de\u4f53\u5185\u90e8\u306b\u84c4\u7a4d\u3057\u305f\u6298\u308a\u7573\u307f\u4e0d\u5168\u30bf\u30f3\u30d1\u30af\u8cea\u3092Ire1\u306f\u76f4\u63a5\u7684\u306b\u8a8d\u8b58\u3057\u3066\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u3001\u79c1\u305f\u3061\u306f\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3000\u3057\u304b\u3057\u4e00\u65b9\u3001\u819c\u8102\u8cea\u306e\u69cb\u6210\u6210\u5206\u306e\u7570\u5e38\u3082\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u308a\u3001Ire1\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3000\u3053\u306e\u5834\u5408\u306eIre1\u6d3b\u6027\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u6298\u308a\u7573\u307f\u4e0d\u5168\u30bf\u30f3\u30d1\u30af\u8cea\u84c4\u7a4d\u306b\u3088\u308b\u3082\u306e\u3068\u306f\u7570\u306a\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u6210\u679c\uff13: <\/strong>\u3069\u306e\u3088\u3046\u306a\u5c40\u9762\u3067\u7d30\u80de\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u306b\u306a\u308b\u306e\u304b\uff1f<\/h2>\n\n\n\n<p>\u4eba\u70ba\u7684\u306a\u5b9f\u9a13\u5ba4\u74b0\u5883\u3084\u907a\u4f1d\u5b50\u64cd\u4f5c\u4ee5\u5916\u306e\u3069\u306e\u3088\u3046\u306a\u5c40\u9762\u3067\u7d30\u80de\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u306b\u306a\u308a\u3001UPR\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u79c1\u305f\u3061\u306f\u9175\u6bcd\u7d30\u80de\u3092\u30e2\u30c7\u30eb\u3068\u3057\u3066\u3001\u305d\u306e\u554f\u984c\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3000\u79c1\u305f\u3061\u306e\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u73fe\u5728\u3067\u3082\u74b0\u5883\u6c5a\u67d3\u7269\u8cea\u3068\u3057\u3066\u4e16\u754c\u4e2d\u3067\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u30ab\u30c9\u30df\u30a6\u30e0\u304c\u3001\u5c0f\u80de\u4f53\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3000\u307e\u305f\u3001\u9175\u6bcd\u306b\u3088\u308b\u30a8\u30bf\u30ce\u30fc\u30eb\u767a\u9175\u306f\u7523\u696d\u7684\u306b\u3082\u91cd\u8981\u306a\u4e8b\u8c61\u3067\u3059\u304c\u3001\u9ad8\u6fc3\u5ea6\u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u308a\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u767a\u9175\u4e2d\u306e\u7d30\u80de\u969c\u5bb3\u306e\u4e00\u56e0\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7814\u7a76\u6210\u679c4:<\/strong> \u5e38\u306bUPR\u304c\u8d77\u304d\u3066\u3044\u308b\u9175\u6bcd\u7d30\u80de\u306e\u4f5c\u88fd\u3068\u5fdc\u7528<\/h2>\n\n\n\n<p>\u4e0a\u8ff0\u306e\u3088\u3046\u306b\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306b\u5fdc\u3058\u3066Ire1\u304c\u591a\u91cf\u4f53\u5316\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001\u9175\u6bcd\u7d30\u80de\u3067\u306f<em>HAC1<\/em> mRNA\u3092\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306b\u3088\u308a\u6210\u719f\u3055\u305b\u307e\u3059\u3002\u3000\u305d\u3057\u3066\u3001\u6210\u719f\u578b<em>HAC1<\/em> mRNA\u306e\u7ffb\u8a33\u7523\u7269\u3067\u3042\u308bHac1\u306f\u3001UPR\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u8a98\u5c0e\u3092\u62c5\u3044\u307e\u3059\u3002\u3000\u3067\u306f\u3001\u6210\u719f\u578b<em>HAC1 <\/em>mRNA\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3092\u9175\u6bcd\u7d30\u80de\u306b\u5c0e\u5165\u3057\u3001Hac1\u3092\u6052\u5e38\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u3068\u3001\u3069\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u8d77\u304d\u308b\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u305d\u306e\u3088\u3046\u306a\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u3067\u306f\u3001\u5916\u90e8\u304b\u3089\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3092\u4e0e\u3048\u306a\u304f\u3066\u3082\u5e38\u306b\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u304c\u8d77\u304d\u3001\u5c0f\u80de\u4f53\u306e\u30b5\u30a4\u30ba\u3084\u6a5f\u80fd\u304c\u5897\u5927\u3057\u307e\u3059\u3002\u3000\u5c0f\u80de\u4f53\u306f\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u3084\u4fee\u98fe\u3092\u884c\u3044\u3001\u307e\u305f\u3001\u8102\u8cea\u5206\u5b50\u306e\u751f\u5408\u6210\u3092\u884c\u3046\u30aa\u30eb\u30ac\u30cd\u30e9\u3067\u3059\u3002\u3000\u79c1\u305f\u3061\u304c\u4f5c\u88fd\u3057\u305f\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u3067\u306f\u3001\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u8102\u8cea\u985e\u306e\u7523\u751f\u91cf\u304c\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"407\" height=\"227\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/research5.png\" alt=\"\" class=\"wp-image-132\" style=\"width:516px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color has-medium-font-size wp-elements-bca199fc279f57bd4a4e84190e894f92\"><strong>\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u306b\u304a\u3051\u308b\u5c0f\u80de\u4f53\u306e\u4f38\u5c55<\/strong><\/p>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color wp-elements-97c5cbe93b7c07525487fa861d47b2f9\">RFP\u2015Elo\uff12\u306e\u767a\u73fe\u306b\u3088\u308a\u5c0f\u80de\u4f53\u3092\u53ef\u8996\u5316\u3057\u305f\u7d30\u80de\u306e\u86cd\u5149\u9855\u5fae\u93e1\u5199\u771f<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"405\" height=\"227\" src=\"https:\/\/bsw3.naist.jp\/LabsW\/kimata\/wp-content\/uploads\/research6.png\" alt=\"\" class=\"wp-image-133\" style=\"width:500px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color has-medium-font-size wp-elements-fc0c55e1a6b3483b02b14d108e8d6311\"><strong><strong>\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u306b\u304a\u3051\u308b\u8102\u8cea\u985e\u751f\u7523\u306e\u5411\u4e0a<\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-nv-c-1-color has-text-color has-link-color wp-elements-876ee18cd111e3c60d31dfccf10e666e\">\u9175\u6bcd\u682a\u306b\u4ed6\u7a2e\u751f\u7269\u306e\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u5408\u6210\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3057\u3001\u5bd2\u5929\u57f9\u5730\u4e0a\u3067\u5897\u6b96\u3055\u305b\u305f\u3002\u91ce\u751f\u578b\u9175\u6bcd\u7d30\u80de\u306b\u6bd4\u3079\u3066\u3001\u6052\u5e38\u7684Hac1\u767a\u73fe\u7d30\u80de\u306f\u591a\u304f\u306e\u03b2-\u30ab\u30ed\u30c6\u30f3\u3092\u751f\u6210\u3057\u3001\u6fc3\u304f\u7740\u8272\u3057\u3066\u3044\u308b\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull last-cover\" style=\"min-height:600px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-nv-light-bg-background-color has-background-dim-100 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u3053\u308c\u304b\u3089\u306e\u7814\u7a76\u30c6\u30fc\u30de<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u30a8\u30bf\u30ce\u30fc\u30eb\u767a\u9175\u3068UPR\u3068\u306e\u95a2\u308f\u308a<\/h3>\n\n\n\n<p>\u9175\u6bcd\u304c\u884c\u3046\u30a8\u30bf\u30ce\u30fc\u30eb\u767a\u9175\u306f\u3001\u91b8\u9020\u3084\u88fd\u30d1\u30f3\u3001\u305d\u3057\u3066\u30d0\u30a4\u30aa\u30a8\u30bf\u30ce\u30fc\u30eb\u88fd\u9020\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059\u3002\u3000\u30a8\u30bf\u30ce\u30fc\u30eb\u304c\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u308aUPR\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306f\u3001\u5b9f\u9a13\u5ba4\u30ec\u30d9\u30eb\u306e\u7814\u7a76\u3067\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3057\u304b\u3057\u3001\u9175\u6bcd\u3092\u30a8\u30bf\u30ce\u30fc\u30eb\u751f\u7523\u306b\u7528\u3044\u308b\u5c40\u9762\u306b\u304a\u3044\u3066\u3001\u3069\u306e\u7a0b\u5ea6\u306bUPR\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u304b\u3001\u305d\u3057\u3066\u3001UPR\u304c\u30a8\u30bf\u30ce\u30fc\u30eb\u767a\u9175\u3092\u52a9\u3051\u308b\u306e\u304b\u963b\u5bb3\u3059\u308b\u306e\u304b\u3082\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3000\u305d\u3053\u3067\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u306f\u3001\u91b8\u9020\u306a\u3069\u5834\u9762\u3067UPR\u3092\u30e2\u30cb\u30bf\u30fc\u3057\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u30a8\u30bf\u30ce\u30fc\u30eb\u751f\u7523\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:36px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u4eba\u70ba\u7684\u306bUPR\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u9175\u6bcd\u7d30\u80de\u3092\u7269\u8cea\u751f\u7523\u306b\u7528\u3044\u308b<\/h3>\n\n\n\n<p>\u9175\u6bcd\u3092\u7528\u3044\u3066\u751f\u7523\u3055\u308c\u305f\u30d2\u30c8\u7531\u6765\u306e\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30db\u30eb\u30e2\u30f3\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u6297\u4f53\u65ad\u7247\u306a\u3069\uff09\u306f\u3001\u30d0\u30a4\u30aa\u533b\u85ac\u54c1\u3068\u3057\u3066\u5b9f\u7528\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3000\u307e\u305f\u3001\u73fe\u5728\u306f\u4e3b\u3068\u3057\u3066\u690d\u7269\u304b\u3089\u4f5c\u3089\u308c\u3066\u3044\u308b\u6cb9\u8102\u3084\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u306a\u3069\u306e\u8102\u8cea\u985e\u3092\u9175\u6bcd\u306b\u3066\u88fd\u9020\u3059\u308b\u3053\u3068\u3082\u3001\u8fd1\u3044\u5c06\u6765\u306b\u306f\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3000\u3053\u308c\u3089\u306e\u6709\u7528\u7269\u8cea\u306f\u5c0f\u80de\u4f53\u3067\u4f5c\u3089\u308c\u308b\u306e\u3067\u3001\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u3092\u7528\u3044\u3066\u5c0f\u80de\u4f53\u306e\u6a5f\u80fd\u3084\u30b5\u30a4\u30ba\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5897\u7523\u3067\u304d\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u3000\u3057\u304b\u3057\u3001\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u306e\u30c7\u30e1\u30ea\u30c3\u30c8\u3068\u3057\u3066\u3001\u5897\u6b96\u306e\u9045\u3055\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u3000\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u3055\u3089\u306a\u308b\u907a\u4f1d\u5b50\u6539\u5909\u3092\u52a0\u3048\u3066\u3053\u306e\u30c7\u30e1\u30ea\u30c3\u30c8\u3092\u89e3\u6c7a\u3057\u3001\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u306b\u3088\u308b\u7269\u8cea\u751f\u7523\u3092\u5b9f\u7528\u5316\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001UPR\u306b\u3088\u308a\u4ee3\u8b1d\u7d4c\u8def\u304c\u5909\u5316\u3059\u308b\u306a\u3089\u3070\u3001\u6052\u5e38\u7684Hac1\u767a\u73fe\u9175\u6bcd\u7d30\u80de\u306f\u5e02\u5834\u4fa1\u5024\u306e\u3042\u308b\u6c34\u6eb6\u6027\u4ee3\u8b1d\u7523\u7269\u306e\u88fd\u9020\u306b\u3082\u7528\u3044\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u8010\u71b1\u6027\u9175\u6bcd<em>Kluyveromyces marxianus<\/em><\/h3>\n\n\n\n<p>\u9175\u6bcd<em>Kluyveromyces marxianus<\/em>\u306f\u300150\u2103\u8fd1\u304f\u306e\u9ad8\u6e29\u3067\u3082\u5897\u6b96\u3067\u304d\u308b\u3068\u3044\u3046\u3001\u6975\u3081\u3066\u30e6\u30cb\u30fc\u30af\u306a\u7279\u6027\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u9ad8\u6e29\u3067\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u304c\u963b\u5bb3\u3055\u308c\u3001\u591a\u304f\u306e\u751f\u7269\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u306b\u306a\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u306f\u3001UPR\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u3092\u8db3\u304c\u304b\u308a\u3068\u3057\u3066\uff08\u307e\u305f\u3001UPR\u4ee5\u5916\u306e\u3053\u3068\u306b\u3082\u8996\u91ce\u3092\u5e83\u3052\u3066\uff09\u3001<em>Kluyveromyces marxianus<\/em>\u304c\u9ad8\u6e29\u8010\u6027\u3092\u6301\u3064\u4ed5\u7d44\u307f\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u307e\u3059\u3002\u305d\u306e\u7814\u7a76\u6210\u679c\u306b\u3088\u308a\u3001\u751f\u7269\u304c\u9ad8\u6e29\u3067\u3082\u80b2\u3064\u3053\u3068\u304c\u3067\u304d\u308b\u624b\u6bb5\u304c\u898b\u3064\u3051\u51fa\u3055\u308c\u3001\u5730\u7403\u6e29\u6696\u5316\u306e\u6642\u4ee3\u306b\u9069\u3057\u305f\u8fb2\u696d\u306e\u5c55\u958b\u306b\u7e4b\u304c\u308b\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u3001<em>Kluyveromyces marxianus<\/em>\u306f\u6728\u8cea\u7cfb\u306e\u30d0\u30a4\u30aa\u30de\u30b9\u3092\u5229\u7528\u3059\u308b\u80fd\u529b\u304c\u9ad8\u304f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u985e\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u30d0\u30a4\u30aa\u71c3\u6599\u751f\u7523\u306e\u305f\u3081\u306e\u5b9f\u7528\u5316\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u3092\u542b\u3080\u30a2\u30eb\u30b3\u30fc\u30eb\u306f\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3092\u542b\u3080\u69d8\u3005\u306a\u30b9\u30c8\u30ec\u30b9\u3092\u7d30\u80de\u306b\u4e0e\u3048\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u306f\u30bf\u30a4\u306e\u7814\u7a76\u6a5f\u95a2\u3068\u5354\u529b\u3057\u3001<em>Kluyveromyces marxianus<\/em>\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u3092\u9ad8\u3081\u3001\u9ad8\u3044\u53ce\u91cf\u3067\u30a2\u30eb\u30b3\u30fc\u30eb\u751f\u7523\u304c\u53ef\u80fd\u306a\u682a\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3082\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">UPR\u306f\u9175\u6bcd\u7d30\u80de\u306b\u3069\u306e\u3088\u3046\u306a\u751f\u7406\u7684\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u304b\uff1f<\/h3>\n\n\n\n<p>Hac1\u306f\u6570\u591a\u304f\u306e\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u4f5c\u7528\u3057\u3001\u591a\u5f69\u306a\u907a\u4f1d\u5b50\u304cUPR\u306b\u3088\u3063\u3066\u767a\u73fe\u5909\u52d5\u3057\u307e\u3059\u3002\u3000\u5c0f\u80de\u4f53\u5c40\u5728\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306a\u3069\u3001\u5c0f\u80de\u4f53\u3067\u50cd\u304f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u8a98\u5c0e\u306f\u3001\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306e\u7de9\u548c\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u5bb9\u6613\u306b\u60f3\u50cf\u3067\u304d\u307e\u3059\u3002\u3000\u3057\u304b\u3057\u3001\u306a\u305cHac1\u306e\u6a19\u7684\u306b\u306a\u308b\u306e\u304b\u5206\u304b\u3089\u306a\u3044\u907a\u4f1d\u5b50\u3082\u591a\u304f\u3001\u9175\u6bcd\u7d30\u80de\u304cUPR\u3092\u8d77\u3053\u3057\u3066\u304b\u3089\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u3092\u8131\u3059\u308b\u307e\u3067\u306e\u9053\u7b4b\u306f\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3000Hac1\u306e\u767a\u73fe\u306b\u3088\u308a\u591a\u304f\u306e\u4ee3\u8b1d\u9175\u7d20\u907a\u4f1d\u5b50\u7fa4\u306e\u767a\u73fe\u3082\u5909\u52d5\u3059\u308b\u306e\u3067\u3001UPR\u306b\u3088\u3063\u3066\u3055\u307e\u3056\u307e\u306a\u4ee3\u8b1d\u7d4c\u8def\u306b\u5927\u304d\u306a\u5909\u5316\u304c\u751f\u3058\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3000UPR\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u7d30\u80de\u3092\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u306a\u3069\u306b\u4f9b\u3059\u308b\u3053\u3068\u3092\u901a\u3058\u3001\u3069\u306e\u3088\u3046\u306a\u4ee3\u8b1d\u7523\u7269\u304cUPR\u306b\u3088\u3063\u3066\u5897\u6e1b\u3057\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u306e\u7de9\u548c\u306b\u7e4b\u304c\u308b\u304b\u3001\u89e3\u660e\u3059\u3079\u304f\u7814\u7a76\u3092\u59cb\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u30d2\u30c8\u306e\u75be\u60a3\u3068UPR\u3068\u306e\u95a2\u308f\u308a<\/h3>\n\n\n\n<p>\u3042\u308b\u7a2e\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u306f\u3001\u6298\u308a\u7573\u307f\u4e0d\u5168\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u767a\u75c7\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u3000\u30b5\u30a4\u30c8\u30be\u30eb\u306b\u6e9c\u307e\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u304c\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u3063\u3066\u75c7\u72b6\u3092\u60aa\u5316\u3055\u305b\u308b\u4e8b\u4f8b\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3000\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9175\u6bcd\u7d30\u80de\u306b\u3066\u767a\u73fe\u3055\u305b\u3001\u3069\u306e\u3088\u3046\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u5c0f\u80de\u4f53\u306b\u30c0\u30e1\u30fc\u30b8\u304c\u4e0e\u3048\u3089\u308c\u308b\u306e\u304b\u3082\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"on","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"on","footnotes":""},"class_list":["post-126","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/pages\/126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/comments?post=126"}],"version-history":[{"count":0,"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/pages\/126\/revisions"}],"wp:attachment":[{"href":"https:\/\/bsw3.naist.jp\/kimata\/wp-json\/wp\/v2\/media?parent=126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}