腫瘍細胞生物学研究室

研究業績

<論文・著書>

Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development. Hidenori Ito, Ikuko Nakamae, Jun-ya Kato, and Noriko Yoneda-Kato. The Journal of Clinical Investigation, in press. 

The Target Differences of Anti-Tumorigenesis Potential of Curcumin and Its Analogues Against HER-2 Positive and Triple-Negative Breast Cancer Cells. Edy Meiyanto, Ulfatul Husnaa, Ria Fajarwati Kastian, Herwandhani Putri, Yonika Arum Larasati, Annisa Khumaira, Dyaningtyas Dewi Putri Pamungkas, Riris Istighfari Jenie, Masashi Kawaichi, Beni Lestari, Takashi Yokoyama, Jun-ya Kato; Adv Pharm Bull. 2021;11(1): 188-196. doi: 10.34172/apb.2021.020

A new curcumin analog, CCA-1.1, induces cell cycle arrest and senescence toward ER-positive breast cancer cells. Dhania Novitasari, Febri Wulandari, Riris Istighfari Jenie, Rohmad Yudi Utomo, Jun-Ya Kato, Edy Meiyanto; International Journal of Pharmaceutical Research, Volume 13 , Issue 1, Jan - Mar, 2021, ISSN: 0975-2366, doi.org/10.31838/ijpr/2021.13.01.002

New curcumin analog, CCA-1.1, synergistically improves the antiproliferative effect of doxorubicin against T47D breast cancer cells. Febri Wulandari, Muthi’ Ikawati, Dhania Novitasari, Mitsunori Kirihata, Jun-ya Kato, Edy Meiyanto; Indonesian Journal of Pharmacy, 31(4), 244-256, 2020, https://doi.org/10.22146/ijp.681

The anti-migratory activity of a new curcumin analog, CCA-1.1, against T47D breast cancer cells. Febri Wulandari, Rohmad Yudi Utomo, Dhania Novitasari, Muthi’ Ikawati, Mitsunori Kirihata, Jun-Ya Kato, Edy Meiyanto; International Journal of Pharmaceutical Research, Volume 13 , Issue 1, Jan - Mar, 2021, https://doi.org/10.31838/ijpr/2021.13.01.421

A Curcumin Like Structure (CCA-1.1) Induces Permanent Mitotic Arrest (Senescence) on Triple Negative Breast Cancer (TNBC) Cells, 4T1.Dhania Novitasari, Riris Istighfari Jenie, Febri Wulandari, Rohmad Yudi Utomo, Dyaningtyas Dewi Pamungkas Putri, Jun-ya Kato, Edy Meiyanto; Research Journal of Pharmacy and Technology, in press. 

Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression.
Nakamae I, Morimoto T, Shima H, Shionyu M, Fujiki H, Yoneda-Kato N, Yokoyama T, Kanaya S, Kakiuchi K, Shirai T, Meiyanto E, Kato JY.
Molecules. 2019 Nov 10;24(22). pii: E4067. doi: 10.3390/molecules24224067.

Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence.
Lestari B, Nakamae I, Yoneda-Kato N, Morimoto T, Kanaya S, Yokoyama T, Shionyu M, Shirai T, Meiyanto E, Kato JY.
Sci Rep. 2019 Oct 16;9(1):14867. doi: 10.1038/s41598-019-51244-3.

Cell cycle modulation of CHO-K1 cells under Genistein treatment correlates with cells senescence, apoptosis and ROS level but in a dose-dependent manner.
Jenie RI, Amalina ND, Ilmawati GPN, Utomo RY, Ikawati M, Kato JY,Meiyanto E.
Advanced Pharmaceutical Bulletin, 2019, 9(3):453-461

Anti-Proliferative and Anti-Metastatic Potential of Curcumin Analogue, Pentagamavunon-1 (Pgv-1), Toward Highly Metastatic Breast Cancer Cells in Correlation With Ros Generation.
Meiyanto E, Putri H, Arum Larasati Y, Yudi Utomo R, Jenie RI, Ikawati M, Lestari B, Yoneda-Kato N, Nakamae I, Kawaichi M, Kato JY.
Advanced Pharmaceutical Bulletin, 2019, 9(3):445-452 

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.
Larasati YA, Yoneda-Kato N, Nakamae I, Yokoyama T, Meiyanto E, Kato JY.
Sci Rep. 2018 Feb 1;8(1):2039. doi: 10.1038/s41598-018-20179-6.

Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia.
Nakamae I, Kato JY, Yokoyama T, Ito H, Yoneda-Kato N.
Blood Adv. 2017 Sep 1;1(20):1682-1693. doi: 10.1182/bloodadvances.2017007054. eCollection 2017 Sep 12.

Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs.
Kukita Y, Okami J, Yoneda-Kato N, Nakamae I, Kawabata T, Higashiyama M, Kato J, Kodama K, Kato K.
Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001032.

COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.
Yoshida A, Kato JY, Nakamae I, Yoneda-Kato N.
Blood. 2013 Sep 5; 122(10):1750-60. doi: 10.1182/blood-2012-12-476101. Epub 2013 Jul 24.

CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner.
Yoshida A, Yoneda-Kato N, Kato JY.
Sci Rep. 2013; 3:1054. doi: 10.1038/srep01054. Epub 2013 Jan 11.

The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy.
Kobayashi S, Yoneda-Kato N, Itahara N, Yoshida A, Kato JY.
BMC Biochem. 2013 Jan 6;14:1. doi: 10.1186/1471-2091-14-1.

Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells.
Tsujimoto I, Yoshida A, Yoneda-Kato N, Kato JY.
FEBS Lett. 2012 Dec 14;586(24):4326-31. doi: 10.1016/j.febslet.2012.10.042. Epub 2012 Nov 2.

New twist in the regulation of cyclin D1.
Kato JY, Yoneda-Kato N.
Biomol Concepts. 2010 Dec 1;1(5-6):403-9. doi: 10.1515/bmc.2010.029.

CSN5/Jab1 controls multiple events in the mammalian cell cycle.
Yoshida A, Yoneda-Kato N, Panattoni M, Pardi R, Kato JY.
FEBS Lett. 2010 Nov 19;584(22):4545-52. doi: 10.1016/j.febslet.2010.10.039. Epub 2010 Oct 26.

 

<学会発表、招待講演等>

2019年
・3rd International Current Breakthrough in Pharmacy (ICB-Pharma 2019)(招待講演)
・10th Annual Conference of Indonesian Society for Cancer Chemoprevention (ISCC) and International Summit on Science Technology and Humanity (ISETH2019)(招待講演)
・第78回日本癌学会学術総会(英語口頭発表に2演題が採択)

2018年
・第9回ISCC国際シンポジウム(招待講演)
・BioBIC 2018 International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering(招待講演)
・第77回日本癌学会学術総会(英語口頭発表に採択)
・第41回日本分子生物学会(ワークショップで招待講演)
・Mechanisms & Models of Cancer(Cold Spring Harbor Laboratory Meeting)

2017年
・第76回日本癌学会学術総会
・Biology of Cancer: Microenvironment & Metastasis(Cold Spring Harbor Laboratory Meeting)

2016年
・WHICAPS 2016 International Conference国際学会(招待講演)
・81st Symposium: Cancer(Cold Spring Harbor Laboratory Meeting)
・第75回日本癌学会学術総会

2015年
・PICAPS 2015国際シンポジウム(招待講演)
・第1回UMP-PIC国際シンポジウム(招待講演)
・第74回日本癌学会学術総会
・Tribbles Meeting 2015(招待講演)

2014年
・16th International p53 workshop
・Zomes VIII Conference (招待講演)
・第73回日本癌学会学術総会

2013年
・第72回日本癌学会学術総会
・第36回日本分子生物学会年会

2012年
・ZOMESVII 国際学会(招待講演)

2011年
・第70回日本癌学会学術総会
・第34回日本分子生物学会年会

2010年
・ZOMES VI 国際学会(招待講演)

 

<特許権等知的財産権の取得及び申請状況>

(1)出願日:2018年4月2日

(2)出願日:2018年10月17日

(3)出願日:準備中(2019年内に出願予定)


前の論文等

 
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