奈良先端科学技術大学院大学 バイオサイエンス研究科 分子免疫制御(河合研究室)

Publications(2012年以前)

  • 100
    Demoor T, Petersen BC, Morris S, Mukherjee S, Ptaschinski C, De Almeida Nagata DE, Kawai T, Ito T, Akira S, Kunkel SL, Schaller MA, Lukacs NW.
    IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus.
    J Immunol. 2012 Dec 15;189(12):5942-53.
    PMID: 23136205
  • 099
    Oldenburg M, Kruger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ.
    TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.
    Science. 2012 Aug 31;337(6098):1111-5.
    PMID: 22821982
  • 098
    Kondo T, Kawai T, Akira S.
    Dissecting negative regulation of Toll-like receptor signaling.
    Trends Immunol. 2012 Sep;33(9):449-58.
    PMID: 22721918
  • 097
    Biswas A, Meissner TB, Kawai T, Kobayashi KS.
    Cutting Edge: impaired MHC class I expression in mice deficient for Nlrc5/Class I transactivator.
    J Immunol. 2012 Jul 15;189(2):516-20.
    PMID: 22711889
  • 096
    Abe T, Fukuhara T, Wen X, Ninomiya A, Moriishi K, Maehara Y, Takeuchi O, Kawai T, Akira S, Matsuura Y.
    CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA Is replicating, through an interaction with Toll-Like Receptor 2 and Hyaluronan.
    J Virol. 2012 Jun;86(11):6159-70.
    PMID: 22491449
  • 095
    Kawasaki TKawai T, Akira S.
    Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity.
    Immunol Rev. 2011 Sep;243(1):61-73.
    PMID: 21884167
  • 094
    Kawai T, Akira S.
    Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins.
    EMBO Mol Med. 2011 Sep;3(9):513-27.
    PMID: 21826793
  • 093
    Matsumoto K, Kan-O K, Eguchi-Tsuda M, Fukuyama S, Asai Y, Matsumoto T, Moriwaki A, Matsunaga Y, Tsutsui H, Kawai T, Takeuchi O, Akira S, Yagita H, Azuma M, Nakanishi Y, Inoue H.
    Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice.
    Am J Respir Cell Mol Biol. 2011 Jul;45(1):31-9.
    PMID: 20802088
  • 092
    Kim YG, Park JH, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C, Nunez G.
    Viral infection augments nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.
    Cell Host Microbe. 2011 Jun 16;9(6):496-507.
    PMID: 21669398
  • 091
    Kawai T, Akira S.
    Toll-like Receptors and their crosstalk with other innate receptors in infection and immunity.
    Immunity. 2011 May 27;34(5):637-50.
    PMID: 21616434
  • 090
    Togi S, Ikeda O, Kamitani S, Nakasuji M, Sekine Y, Muromoto R, Nanbo A, Oritani K, Kawai T, Akira S, Matsuda T.
    Zipper-interacting protein kinase modulates canonical Wnt/beta-catenin signaling through interacting with Nemo-like kinase and T-cell factor 4.
    J Biol Chem. 2011 May 27;286(21):19170-7.
    PMID: 21454679
  • 089
    Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S.
    Antiviral protein Viperin promotes Toll-like Receptor 7- and Toll-like Receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
    Immunity. 2011 Mar 25;34(3):352-63.
    PMID: 21435586
  • 088
    Kumar H, Kawai T, Akira S.
    Pathogen recognition by the innate immune system.
    Int Rev Immunol. 2011 Feb;30(1):16-34.
    PMID: 21235323
  • 087
    Kumar H, Pandey S, Zou J, Kumagai Y, Takahashi K, Akira S, Kawai T.
    NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.
    J Immunol. 2011 Jan 15;186(2):994-1000.
    PMID: 21148033
  • 086
    Ueta M, Kawai T, Yokoi N, Akira S, Kinoshita S.
    Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells.
    Biochem Biophys Res Commun. 2011 Jan 7;404(1):419-23.
    PMID: 21130742
  • 085
    Seo SU, Kwon HJ, Song JH, Byun YH, Seong BL, Kawai T, Akira S, Kweon MN.
    MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection.
    J Virol. 2010 Dec;84(24):12713-22.
    PMID: 20943980
  • 084
    Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, *Kawai T, *Akira S.
    The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.
    Immunity. 2010 Nov 24;33(5):765-76.
    PMID: 21074459
    * Correspondence
  • 083
    Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, Miyazaki T.
    Influenza A virus polymerase inhibits type I interferon induction by binding to interferon {beta} promoter stimulator 1.
    J Biol Chem. 2010 Oct 15;285(42):32064-74.
    PMID: 20699220
  • 082
    Kawai T, Akira S.
    The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
    Nat Immunol. 2010 May;11(5):373-84.
    PMID: 20404851
  • 081
    Kobiyama K, Takeshita F, Jounai N, Sakaue-Sawano A, Miyawaki A, Ishii KJ, Kawai T, Sasaki S, Hirano H, Ishii N, Okuda K, Suzuki K.
    Extra-chromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.
    J Virol. 2010 Jan;84(2):822-32.
    PMID: 19906922
  • 080
    Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T.
    IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation.
    Cell Death Differ. 2009 Dec;16(12):1615-21.
    PMID: 19644511
  • 079
    Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, Saitoh T, Akira S, Kawai T.
    Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal {beta}-glucan.
    J Immunol. 2009 Dec 15;183(12):8061-8067.
    PMID: 20007575
  • 078
    Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S.
    Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
    Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-20846.
    PMID: 19926846
  • 077
    Kumar H, Kawai T, Akira S.
    Toll-like receptors and innate immunity.
    Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5.
    PMID: 19686699
  • 076
    Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S.
    Poly I:C-induced activation of NK cells by CD8{alpha}+ dendritic cells via the IPS-1 and TRIF-dependent pathways.
    J Immunol. 2009 Aug 15;183(4):2522-8..
    PMID: 1963590
  • 075
    Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G.
    Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
    Immunity. 2009 Jul 17;31(1):25-34.
    PMID: 19576794
  • 074
    Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, Matsuura Y.
    Baculovirus induces type I IFN production through TLR-dependent and -independent pathways in a cell type-specific manner.
    J Virol. 2009 Aug;83(15):7629-40.
    PMID: 19474102
  • 073
    Kumar H, Kawai T, Akira S.
    Pathogen recognition in the innate immune response.
    Biochem J. 2009 Apr 28;420(1):1-16.
    PMID: 19382893
  • 072
    Kawai T, Akira S.
    The roles of TLRs, RLRs and NLRs in pathogen recognition.
    Int Immunol. 2009 Apr;21(4):317-37.
    PMID: 19246554
  • 071
    Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S.
    Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
    J Immunol. 2009 Apr 1;182(7):3960-4.
    PMID: 19299691
  • 070
    Tsuchida T, Kawai T, Akira S.
    Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins.
    Cell Res. 2009 Jan;19(1):3-4.
    PMID: 19125153
  • 069
    Kawai T, Akira S
    Toll-like Receptor and RIG-I-like Receptor signaling.
    Ann N Y Acad Sci. 2008 Nov;1143:1-20.
    PMID: 19076341
  • 068
    Lee PY, Kumagai Y, Li Y, Takeuchi O, Yoshida H, Weinstein J, Kellner ES, Nacionales D, Barker T, Kelly-Scumpia K, van Rooijen N, Kumar H, Kawai T, Satoh M, Akira S, Reeves WH.
    TLR7-dependent and Fc{gamma}R-independent production of type I interferon in experimental mouse lupus.
    J Exp Med. 2008 Dec 22;205(13):2995-3006.
    PMID: 19047436
  • 067
    Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T.
    TNF receptor-associated factor (TRAF) 6 and MEK kinase (MEKK) 1 play a pivotal role in the retinoic-acid-inducible gene-I (RIG-I)-like helices antiviral pathway.
    J Biol Chem. 2008 Dec 26;283(52):36211-20.
    PMID: 18984593
  • 066
    Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
    Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
    Nature. 2008 Nov 13;456(7219):264-8
    PMID: 18849965
  • 065
    Ohbayashi N, Okada K, Kawakami S, Togi S, Sato N, Ikeda O, Kamitani S, Muromoto R, Sekine Y, Kawai T, Akira S, Matsuda T.
    Physical and functional interactions between ZIP kinase and UbcH5.
    Biochem Biophys Res Commun. 2008 Aug 8;372(4):708-12.
    PMID: 18515077
  • 064
    Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S.
    Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
    Nat Immunol. 2008 Jun;9(6):684-91.
    PMID: 18438411
  • 063
    Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S.
    TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
    Nature. 2008 Feb 7;451(7179):725-9.
    PMID: 18256672
  • 062
    Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S.
    Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
    J Immunol. 2008 Jan 15;180(2):683-7.
    PMID: 18178804
  • 061
    Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S.
    Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces cytotoxic T cell response via MyD88.
    J Virol. 2008 Jan;82(1):196-206.
    PMID: 17942529
  • 060
    Kawai T, Akira S.
    Signaling to NF-kappaB by Toll-like receptors.
    Trends Mol Med. 2007 Nov;13(11):460-9.
    PMID: 18029230
  • 059
    Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S.
    Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
    J Immunol. 2007 Oct 1;179(7):4711-20.
    PMID: 17878370
  • 058
    Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
    Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
    J Exp Med. 2007 Sep 3;204(9):2233-9.
    PMID: 17724128
  • 057
    Kumagai Y, Takeuchi O, Kato H, Kumar H, Matsui K, Morii E, Aozasa K, Kawai T, Akira S.
    Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
    Immunity. 2007 Aug;27(2):240-52.
    PMID: 17723216
  • 056
    Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K, Okuda K.
    The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
    Proc Natl Acad Sci USA. 2007 Aug 28;104(35):14050-5.
    PMID: 17709747
  • 055
    Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen X, Taguwa S, Moriishi K, Takeuchi O, Kawai T, Kanto T, Hayashi N, Akira S, Matsuura Y.
    Hepatitis C Virus Nonstructural Protein 5A modulates TLR-MyD88-dependent signaling pathway in the macrophage cell lines.
    J Virol. 2007 Sep;81(17):8953-66.
    PMID: 17567694
  • 054
    Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, van Echo D, Fitzgerald KA, Young HA, Ching LM, Vogel SN.    
    The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
    J Exp Med. 2007 Jul 9;204(7):1559-69.
    PMID: 17562815
  • 053
    Kawai T, Akira S.
    SnapShot: Pattern-Recognition Receptors.
    Cell. 2007 Jun 1;129(5):1024.
    PMID: 17540179
  • 052
    Kawai T, Akira S.
    TLR signaling.
    Semin Immunol. 2007 Feb;19(1):24-32.
    PMID: 17275323
  • 051
    Kawai T, Akira S.    
    Antiviral signaling through pattern recognition receptors.
    J Biochem (Tokyo). 2007 Feb;141(2):137-45.
    PMID: 17190786
  • 050
    Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.
    Pathological role of Toll-like receptor signaling in cerebral malaria.
    Int Immunol. 2007 Jan;19(1):67-79.
    PMID: 17135446
  • 049
    Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.
    Pivotal function of Ubc13 in thymocyte TCR signaling.
    J Immunol. 2006 Dec 1;177(11):7520-4.
    PMID: 17114420
  • 048
    Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S.
    VP1686, a Vibrio type III secretion protein, induces toll-like receptor independent apoptosis in macrophage through NF-kappa B inhibition.
    J Biol Chem. 2006 Dec 1;281(48):36897-36904.
    PMID: 16984916
  • 047
    Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S.
    TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
    Int Immunol. 2006 Oct;18(10):1405-11.
    PMID: 16940043
  • 046
    Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
    Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
    Nat Immunol. 2006 Sep;7(9):962-70.
    PMID: 16862162
  • 045
    Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S.
    Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c(+) lamina propria cells.
    Nat Immunol. 2006 Aug;7(8):868-74.
    PMID: 16829963
  • 044
    Kumar H*, Kawai T*, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S.
    Essential role of IPS-1 in innate immune responses against RNA viruses.
    J Exp Med. 2006 Jul 10;203(7):1795-1803.  
    PMID: 16785313
    *Equal contribution
  • 043
    Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita T, Akira S.
    Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
    Nature. 2006 May 4;441(7089):101-105.
    PMID: 16625202
  • 042
    Kawai T, Akira S
    TLR-signaling.
    Cell Death Differ. 2006 May;13(5):816-825.
    PMID: 16410796
  • 041
    Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S
    Roles of Caspase-8 and Caspase-10 in antiviral innate immune responses.
    J Immunol. 2006 Apr 15;176(8):4520-4524.
    PMID: 16585540
  • 040
    Sato N, Kamada N, Muromoto R, Kawai T, Sugiyama K, Watanabe T, Imoto S, Sekine Y, Ohbayashi N, Ishida M, Akira S, Matsuda T.
    Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.
    Immunol Lett. 2006 Mar 15;103(2):127-134.  
    PMID: 16325270
  • 039
    Kawai T, Akira S.
    Innate immune recognition of viral infection.
    Nat Immunol. 2006 Feb;7(2):131-137.
    PMID: 16424890
  • 038
    Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.
    A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
    Nat Immunol. 2006 Jan;7(1):40-48.
    PMID: 16286919
  • 037
    Sato N, Kawai T, Sugiyama K, Muromoto R, Imoto S, Sekine Y, Ishida M, Akira S, Matsuda T.
    Physical and functional interactions between STAT3 and ZIP kinase.
    Int Immunol. 2005 Dec;17(12):1543-1552.
    PMID: 16219639
  • 036
    Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
    Essential function for the kinase TAK1 in innate and adaptive immune responses.
    Nat Immunol. 2005 Nov;6(11):1087-1095.
    PMID: 16186825
  • 035
    Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S.
    IPS-1; an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Nat Immunol. 2005, Oct;6(10):981-988.
    PMID: 16127453
  • 034
    Kawai T, Akira S.
    Pathogen recognition with Toll-like receptors.
    Curr Opin Immunol. 2005, 17(4):338-344.
    PMID: 15950447
  • 033
    Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.
    Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) plays an essential role for TLR7- and TLR9-mediated interferon-a induction
    J. Exp. Med. 2005, 201(6):915-923.
    PMID: 15767370
  • 032
    Kawai T, Akira S.
    Toll-like receptor downstream signaling.
    Arthritis Res. 2005, 7:12-19
    PMID: 15642149
  • 031
    Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S.
    Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
    J. Exp. Med. 2005 Jan 3; 201 (1): 19-25
    PMID: 15630134
  • 030
    Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira S.
    Interferon-a induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
    Nat Immunol. 2004 Oct;5(10):1061-1068.
    PMID: 15361868
  • 029
    Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.
    The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
    J Exp Med. 2004 Jun 21;199(12):1641-1650.
    PMID: 15210742
  • 028
    Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S.
    Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
    J Immunol. 2003 Oct 15;171(8):4304-4310.
    PMID: 14530355
  • 027
    Kawai T, Akira S, Reed JC.    
    ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
    Mol Cell Biol. 2003 Sep;23(17):6174-6186.
    PMID: 12917339
  • 026
    Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, Hoshino K, Akira S.
    Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.
    J Immunol. 2001 Nov 15;167(10):5887-5894.
    PMID: 11698465
  • 025
    Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S.
    Discrimination of bacterial lipoproteins by Toll-like receptor 6.
    Int Immunol. 2001 Jul;13(7):933-940.
    PMID: 11431423
  • 024
    Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S.
    Endotoxin-induced maturation of MyD88-deficient dendritic cells.
    J Immunol. 2001 May 1;166(9):5688-5694.
    PMID: 11313410
  • 023
    Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N, Akira S.    
    IkappaB kinase alpha is essential for mature B cell development and function.
    J Exp Med. 2001 Feb 19;193(4):417-426.
    PMID: 11181694
  • 022
    Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S.
    A Toll-like receptor recognizes bacterial DNA.
    Nature. 2000 Dec 7;408(6813):740-745.
    PMID: 11130078
  • 021
    Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, Takeda K, Akira S.
    Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
    J Immunol. 2000 Dec 15;165(12):7096-7101.
    PMID: 11120839
  • 020
    Sakao Y, Kawai T, Takeuchi O, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
    Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.
    Genomics. 2000 Jul 1;67(1):1-7.
    PMID: 10945464
  • 019
    Nomura F*, Kawai T*, Nakanishi K, Akira S. (* contributed equally)    
    NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
    Genes Cells. 2000 Mar;5(3):191-202.
    PMID: 10759890
    *Equal contribution
  • 018
    Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S.    
    Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.
    J Immunol. 2000 Apr 1;164(7):3476-3479.
    PMID: 10725699
  • 017
    Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Muhlradt PF, Akira S.
    Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway.
    J Immunol. 2000 Jan 15;164(2):554-557.
    PMID: 10623793
  • 016
    Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S.    
    Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice.
    J Exp Med. 1999 Dec 6;190(11):1573-1582.
    PMID: 10587348
  • 015
    Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.    
    Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
    Immunity. 1999 Oct;11(4):443-451.
    PMID: 10549626
  • 014
    Kawai T, Adachi O, Ogawa T, Takeda K, Akira S.
    Unresponsiveness of MyD88-deficient mice to endotoxin.
    Immunity. 1999 Jul;11(1):115-122.
    PMID: 10435584
  • 013
    Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S.
    IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
    Int Immunol. 1999 Aug;11(8):1357-1362.
    PMID: 10421793
  • 012
    Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.
    Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
    Oncogene. 1999 Jun 10;18(23):3471-3480.
    PMID: 10376525
  • 011
    Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
    TLR6: A novel member of an expanding toll-like receptor family.
    Gene. 1999 Apr 29;231(1-2):59-65.
    PMID: 10231569
  • 010
    Hoshino K, Tsutsui H, Kawai T, Takeda K, Nakanishi K, Takeda Y, Akira S.
    Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.
    J Immunol. 1999 May 1;162(9):5041-5044.
    PMID: 10227969
  • 009
    Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.
    Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
    J Immunol. 1999 Apr 1;162(7):3749-3752.
    PMID: 10201887
  • 008
    Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S.
    Limb and skin abnormalities in mice lacking IKKalpha.
    Science. 1999 Apr 9;284(5412):313-316.
    PMID: 10195895
  • 007
    Kawai T, Sanjo H, Akira S.
    Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.
    Gene. 1999 Feb 18;227(2):249-255.
    PMID: 10023074
  • 006
    Sanjo H, Kawai T, Akira S.
    DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
    J Biol Chem. 1998 Oct 30;273(44):29066-29071.
    PMID: 9786912
  • 005
    Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S.    
    Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
    Immunity. 1998 Jul;9(1):143-150.
    PMID: 9697844
  • 004
    Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
    ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
    Mol Cell Biol. 1998 Mar;18(3):1642-1651.
    PMID: 9488481
  • 003
    Kuwahara K, Kawai T, Mitsuyoshi S, Matsuo Y, Kikuchi H, Imajoh-Ohmi S, Hashimoto E, Inui S, Cooper MD, Sakaguchi N.
    Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase.
    Int Immunol. 1996 Aug;8(8):1273-1285.
    PMID: 8918697
  • 002
    Inui S, Kuwahara K, Mizutani J, Maeda K, Kawai T, Nakayasu H, Sakaguchi N.
    Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction.
    J Immunol. 1995 Mar 15;154(6):2714-2723.
    PMID: 7876543
  • 001
    Kuwahara K, Igarashi H, Kawai T, Ichigi Y, Muraguchi A, Mason DY, Kimoto M, Inui S, Sakaguchi N.
    Induction of tyrosine phosphorylation in human B lineage cells by crosslinking MB-1 molecule of B cell receptor-related heterodimer complex.
    Biochem Biophys Res Commun. 1993 Dec 30;197(3):1563-1569.
    PMID: 7506545

 

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