機能ゲノム医学研究室(石田研究室）
Functional Genomics and Medicine
論文リスト Publications
Cardiac fibroblasts regulate the development of heart failure via
Htra3-TGF-β-IGFBP7 axis. [https://pubmed.ncbi.nlm.nih.go
Ko T, Nomura S, Yamada S, Fujita K, Fujita T, Satoh M, Oka C, Katoh M,
Ito M, Katagiri M, Sassa T, Zhang B, Hatsuse S, Yamada T, Harada M, Toko
H, Amiya E, Hatano M, Kinoshita O, Nawata K, Abe H, Ushiku T, Ono M,
Ikeuchi M, Morita H, Aburatani H, Komuro I.
Nat Commun. 2022 Jun 7;13(1):3275. doi: 10.1038/s41467-022-30630-y.
PMID: 35672400 Free PMC article.
Interplay between HTRA1 and classical signalling pathways in
organogenesis and diseases. [https://pubmed.ncbi.nlm.nih.go
Oka C, Saleh R, Bessho Y, Reza HM.
Saudi J Biol Sci. 2022 Apr;29(4):1919-1927. doi:
10.1016/j.sjbs.2021.11.056. Epub 2021 Dec 1. PMID: 35531175 Free PMC
article. Review.
Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression
Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y, and Matsuda E.
Cell Proliferation, e13215, 2022. https://doi.org/10.1111/cpr.13215
Association of the HtrA1 rs11200638 Polymorphism with Neovascular
Age-Related Macular Degeneration in Indonesia. [https://pubmed.ncbi.nlm.nih.go
Supanji S, Perdamaian ABI, Romdhoniyyah DF, Sasongko MB, Agni AN,
Wardhana FS, Widayanti TW, Prayogo ME, Oka C, Kawaichi M.
Ophthalmol Ther. 2022 Feb;11(1):125-133. doi:
10.1007/s40123-021-00402-w. Epub 2021 Nov 2. PMID: 34727349 Free PMC
article.
HtrA1 meets NETs: does it open a new field?
Oka C, Kawaichi M.
Blood. 2021 Sep 16;138(11):920-921. doi: 10.1182/blood.2021013025.
PMID: 34529018 No abstract available.
Neferine Protects Against Brain Damage in Permanent Cerebral Ischemic Rat Associated with Autophagy Suppression and AMPK/mTOR Regulation.
Sengking J, Oka C, Wicha P, Yawoot N, Tocharus J, Chaichompoo W, Suksamrarn A, Tocharus C.
Mol Neurobiol. 2021 Sep 8. doi: 10.1007/s12035-021-02554-z. Online ahead of print.
PMID: 34498225
Diphtheria toxin-mediated transposon-driven poly (A)-trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells. Jie Bai, Ryohei Kondo, N. Ika Mayasari, Toshiaki Shigeoka, Ayako Isotani, Masahito Ikawa, Goro Sashida, Masashi Kawaichi, and Yasumasa Ishida. Genesis in press (2020).
PD-1: Its Discovery, Involvement in Cancer Immunothrapy, and Beyond. Ishida Y. Cells, in press (2020).
それでもわれわれが PD-1 を捨てられない理由. 石田靖雅. 実験医学 36 巻 9 号、p1452-1456, 2018.
Collection of homozygous mutant mouse embryonic stem cells arising from autodiploidization during haploid gene trap mutagenesis. Yamanishi A, Matsuba A, Kondo R, Akamatsu R, Tanaka S, Tokunaga M, Horie K, Kokubu C, IshidaY, Takeda J. Nucleic Acids Res. 2018 (doi: 10.1093/nar/gky183)
PD-1 による免疫学的「自己」の再定義
石田靖雅
ファルマシア 53 巻 10 号、p967-969, 2017
PD-1 の発見について語るときに私の語ること
石田靖雅
現代化学 通巻 551 号、p24-27, 2017
CIBZ Regulates Mesodermal and Cardiac Differentiation of by Suppressing T and Mesp1 Expression in Mouse Embryonic Stem Cells.
Kotoku T, Kosaka K, Nishio M, Ishida Y, Kawaichi M, and Matsuda E.
Sci. Rep. 23, 6, 34188, 2016
哺乳類の発生や分化におけるメチル化 DNA 結合タンパク質の役割
松田永照、西尾美紀、石田靖雅
Bio Clinica 31 巻 5 号、p79-84, 2016
Abnormal development of placenta in HtrA1-deficient mice.
Hasan MZ, Ikawati M, Tocharus J, Kawaichi M, and Oka C.
Dev. Biol. 397, 89-102, 2015
Integrin β1 controls VE-cadherin localization and blood vessel stability.
Yamamoto H, Ehling M, Kato K, Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH.
Nat Commun. 10;6:6429, 2015
新しい癌免疫療法 - PD-1 発見の経緯と研究の歴史 -
石田靖雅
THE LUNG perspectives 23 巻 4 号、p93-97, 2015
PD-1: 発見の経緯と研究の歴史
石田靖雅
Year Book of RCC 2014、p35-41, 2015
今明かす PD-1 発見の舞台裏
石田靖雅
細胞工学 33 巻 10 号、p1038-1041, 2014
HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway.
Supanji, Shimomachi M, Hasan MZ, Kawaichi M, and Oka C.
Exp. Eye Res. 112, 79-92, 2013
Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity.
Shigeoka T, Kato S, Kawaichi M, and Ishida Y.
Nucleic Acids Res.40, 6887-6897, 2012
Mixture of differentially tagged Tol2 transposons accelerates conditional disruption of a broad spectrum of genes in mouse embryonic stem cells.
Mayasari NI, Mukougawa K, Shigeoka T, Kawakami K, Kawaichi M, and Ishida Y.
Nucleic Acids Res. 40, e97, 2012
CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog.
Nishii T, Oikawa T, Ishida Y, Kawaichi M, and Matsuda T.
J. Biol. Chem. 287, 12417-24, 2012
The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression.
Oikawa Y, Omori R, Nishi I, Ishida Y, Kawaichi M, and Matsuda E.
Cell Research 21, 1578-90, 2011
Proteasome activator PA28γ stimulates degradation of GSK3-phosphorylated insulin transcription activator MAFA.
Kanai K, Aramata S, Katakami S, Yasuda K, Kataoka K.
J Mol Endocrinol. 47(1):119-127, 2011
SUMOylation negatively regulates transcriptional and oncogenic activities of MafA.
Kanai K, Reza HM, Kamitani A, Hamazaki Y, Han SI, Yasuda K, Kataoka K.
Genes Cells. 1;15(9):971-82, 2010
Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis.
Oikawa Y, Matsuda E, Nishi T, Ishida Y, and Kawaichi M.
J. Biol. Chem. 283, 14242-47, 2008
Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells.
Shigeoka T, Kawaichi M, and Ishida Y.
Nucleic Acids Res. 33, e20, 2005
Identification of a novel BTB-zinc finger transcriptional repressor, CIBZ, that interacts with CtBP corepressor.
Sasai N, Matsuda E, Sarashina E, Ishida Y, and Kawaichi M.
Genes to Cells 10, 871-85, 2005
Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.
Tsuchiya A, Yano M, Tocharus J, Kojima H, Fukumoto M, Kawaichi M, and Oka C.
Bone 37, 323-336, 2005
NMD 経路の抑制による理想的な遺伝子トラップシステムの構築
重岡稔章、石田靖雅
細胞工学 24 巻 7 号、p729-733, 2005
NMD 経路の抑制による新しい遺伝子トラップシステムの構築
重岡稔章、石田靖雅
バイオテクノロジージャーナル 5 巻 4 号、p464-466, 2005
Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis.
Matsuda E, Shigeoka T, Iida R, Yamanaka S, Kawaichi M, and Ishida Y.
Proc. Natl. Acad. Sci. USA 101, 4170-4174, 2004
Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling.
Tocharus J, Tsuchiya A, Kajikawa M, Ueta Y, Oka C, and Kawaichi M.
Dev. Growth Differ. 46, 257-274, 2004
HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.
Oka C, Tsujimoto R, Kajikawa M, Koshiba-Takeuchi K, Ina J, Yano M, Tsuchiya A, Ueta Y, Soma A, Kanda H, Matsumoto M, Kawaichi M.
Development 131, 1041-1053, 2004
RET: a poly A-trap retrovirus vector for reversible disruption and expression monitoring of genes in living cells.
Ishida Y, Leder P.
Nucleic Acids Res. 27, e35, 1999
Disruption of the Mouse RBP-J Kappa Gene Results in Early Embryonic Death. Oka C, Nakano T, Wakeham A, de la Pompa JL, Mori C, Sakai T, Okazaki S, Kawaichi M, Shiota K, Mak TW, Honjo T.
Development 121, 3291-301, 1995
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Ishida Y, Agata Y, Shibahara K, and Honjo T.
EMBO J. 11, 3887-3895, 1992
